Point-of-care Arkansas method for measuring adherence to treatment with isoniazid
Received 2 September 2009; accepted 1 February 2010. published online 04 March 2010.
Summary
We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.
aInstitute of Thoracic Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
bJohns Hopkins University School of Medicine, Baltimore, MD, USA
Corresponding author. Tuberculosis Clinical Research Laboratory, Institute of Thoracic Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, No. 255, 6° andar, Cidade Universitária, Rio de Janeiro, RJ CEP: 21941-913, Brazil. Tel.: +55 21 2562 2432; fax: +55 21 2562 2853.
ABSTRACT