Respiratory Medicine
Volume 97, Issue 1 , Pages 51-58 , January 2003

G-CSF application in patients with severe bacterial pneumonia increases IL-10 expression in neutrophils

  • S SPUCK

      Affiliations

    • Department of Medicine II
    • Department of Neurosurgery, Medizinische Universitaet Luebeck, Ratzeburger Allee, Luebeck, Germany
  • ,
  • B SCHAAF

      Affiliations

    • Department of Medicine II
  • ,
  • K.H WIEDORN

      Affiliations

    • Institute of Pathology, Klinikum Stuttgart, Kriegsbergstr, Stuttgart, Germany
    • Institute of Pathology, Forschungszentrum Borstel, Parkallee, Borstel, Germany
  • ,
  • F HANSEN

      Affiliations

    • Department of Medicine II
  • ,
  • E VOLLMER

      Affiliations

    • Institute of Pathology, Forschungszentrum Borstel, Parkallee, Borstel, Germany
  • ,
  • K DALHOFF

      Affiliations

    • Department of Medicine II
  • ,
  • J BRAUN

      Affiliations

    • Department of Medicine II

Received 5 February 2002 ,Accepted 27 May 2002.

References 

    REFERENCES
  1. Pachon J, Prados MD, Capote F, Cuello JA, Garnacho J, Verano A. Severe community-acquired pneumonia. Etiology, prognosis, and treatment. Am Rev Respir Dis. 1990;142:369–373
  2. Moore TA, Standiford TJ. The role of cytokines in bacterial pneumonia: an inflammatory balancing act. Proc Assoc Am Physicians. 1998;110:297–305
  3. Belardelli F. Role of interferons and other cytokines in the regulation of the immune response. APMIS. 1995;103:161–179
  4. Strieter RM, Kunkel SL, Bonfield TL. Role of tumor necrosis factor-alpha in disease states and inflammation. Crit Care Med. 1993;21:S447–S463
  5. van der Poll T, Keogh CV, Buurman WA, Lowry SF. Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 1997;155:603–608
  6. Gerard C, Bruyns C, Marchant A. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med. 1993;177:547–550
  7. Remick DG, Garg SJ, Newcomb DE, Wollenberg G, Huie TK, Bolgos GL. Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis [see comments]. Crit Care Med. 1998;26:895–904
  8. Roilides E, Walsh TJ, Pizzo PA, Rubin M. Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis. 1991;163:579–583
  9. Görgen I, Hartung T, Leist M. Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha. J Immunol. 1992;149:918–924
  10. Hartung T, Docke WD, Gantner F. Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood. 1995;85:2482–2489
  11. Dalhoff K, Hansen F, Droemann D, Schaaf B, Aries SP, Braun J. Inhibition of neutrophil apoptosis and modulation of the inflammatory response by granulocyte colony-stimulating factor in healthy and ethanol-treated human volunteers. J Infect Dis. 1998;178:891–895
  12. Mielcarek M, Graf L, Johnson G, Torok Storb B. Production of interleukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood. 1998;92:215–222
  13. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PM. Diagnosis of ventilator associated pneumonia by bacteriologic analysis of bronchocopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143:1121–1128
  14. Wiedorn KH, Lang D, Kuhl H, Galle J, Vollmer E. Sensitive in situ detection of modulated expression levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in bronchial epithelium and leucocytes using cDNA specific primers and direct RT in-situ-PCR. Elec J Pathol Histol. 1999;5:993–1006
  15. Wiedorn KH, Goldmann T, Henne Ch, Kühl H, Vollmer E. Envision+, a new dextran polymer-based signal enhancement technique for in situ hybridization (ISH). J Histochem Cytochem. 2001;49:1067–1071
  16. Nelson S, Belknap SM, Carlson RW. A randomized controlled trial of filgastrim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. J Infect Dis. 1998;178:1075–1080
  17. Armstrong L, Jordan N, Millar A. Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes. Thorax. 1996;51:143–149
  18. Holm R, Karlsen F, Nesland JM. In situ hybridization probes using different detection systems. Mod Pathol. 1992;5:315–319
  19. Michon JM, Gey A, Moutel S. In vivo induction of functional Fc gammaRI (CD64) on neutrophils and modulation of blood cytokine mRNA levels in cancer patients treated with G-CSF (rMetHuG-CSF). Br J Haematol. 1998;100:550–556
  20. Torsteinsdottir I, Arvidson NG, Hallgren R, Hakansson L. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. Scand J Immunol. 1999;50:433–439
  21. Cassatella MA, Gasperini S, Russo MP. Cytokine expression and release by neutrophils. Ann N Y Acad Sci. 1997;832:233–242
  22. Reglier H, Arce Vicioso M, Fay M, Gougerot Pocidalo MA, Chollet Martin S. Lack of IL-10 and IL-13 production by human polymorphonuclear neutrophils. Cytokine. 1998;10:192–198
  23. Keel M, Ungethum U, Steckholzer U. Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood. 1997;90:3356–3363
  24. Koller M, Clasbrummel B, Kollig E, Hahn MP, Muhr G. Major injury induces increased production of interleukin-10 in human granulocyte fractions. Langenbecks Arch Surg. 1998;383:460–465
  25. Romani L, Mencacci A, Cenci E, del Sero G, Bistoni F, Puccetti P. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis. J Immunol. 1997;158:2356–2362
  26. Mencacci A, Cenci E, Spaccapelo R. Neutrophils producing interleukin-10 antagonize the effect of interleukin-12 in mice with candidiasis. Ann N Y Acad Sci. 1996;795:394–396
  27. Powell M, Thompson S, Tone Y, Waldmann H, Tone M. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region. J Immunol. 2000;165:292–296
  28. van Deuren M, Netea M, Hijmans A, Demacker P, Neeleman C, Sauerwein R, et al. Posttranscriptional down-regulation of tumor necrosis factor-alpha and interleukin-1beta production in acute meningococcal infections. J Infect Dis. 1998;177:1401–1405
  29. Lundblad R, Nesland JM, Giercksky KE. Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Crit Care Med. 1996;24:820–826
  30. Kitabayashi A, Hirokawa M, Hatano Y. Granulocyte colony-stimulating factor downregulates allogeneic immune responses by posttranscriptional inhibition of tumor necrosis factor-alpha production. Blood. 1995;86:2220–2227

PII: S0954-6111(02)91414-9

doi: 10.1053/rmed.2002.1414

Respiratory Medicine
Volume 97, Issue 1 , Pages 51-58 , January 2003