Respiratory Medicine
Volume 100, Issue 8 , Pages 1374-1383 , August 2006

Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: A multi-center, double-blind, randomized, and placebo-controlled study in Taiwan

  • Chen-Kuang Niu

      Affiliations

    • Division of Pediatric Pulmonology, Kaohsiung Chang Gung Children's Hospital, Kaohsiung, Taiwan, ROC
  • ,
  • Wu-Yuan Chen

      Affiliations

    • Department of Pediatrics, Medical College, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
  • ,
  • Jing-Long Huang

      Affiliations

    • Division of Pediatric Allergy, Asthma and Rheumatology, Linko Chang Gung Children's Hospital, Taoyuan, Taiwan, ROC
  • ,
  • Ko-Huang Lue

      Affiliations

    • Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC
  • ,
  • Jiu-Yao Wang

      Affiliations

    • Division of Clinical Immunology, Department of Pediatrics, College of Medicine, National Chen-Kung University, No.138, Sheng-Li Road, Tainan, 70428, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +88662353535; fax: +88662753083.

Received 25 August 2005 ,Accepted 23 November 2005.

References 

  1. Ippoliti F, De Sanctis W, Volterrani A. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol. 2003;14:216–221
  2. Sabbah A, Hassoun S, Le Sellin J, Andre C, Sicard H. A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy. 1994;49:309–313
  3. Feliziani V, Lattuada G, Parmiani S, Dall’Aglio PP. Safety and efficacy of sublingual rush immunotherapy with grass allergen extracts. A double blind study. Allergol Immunopathol (Madr). 1995;23:224–230
  4. Tari MG, Mancino M, Monti G. Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. A double-blind study. Allergol Immunopathol (Madr). 1990;18:277–284
  5. Hirsch T, Sahn M, Leupold W. Double-blind placebo-controlled study of sublingual immunotherapy with house dust mite extract (D.pt.) in children. Pediatr Allergy Immunol. 1997;8:21–27
  6. Passalacqua G, Albano M, Fregonese L, Riccio A, Pronzato C, Mela GS, et al. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Lancet. 1998;351:629–632
  7. Troise C, Voltolini S, Canessa A, Pecora S, Negrini AC. Sublingual immunotherapy in Parietaria pollen-induced rhinitis: a double-blind study. J Invest Allergol Clin Immunol. 1995;5:25–30
  8. Rakoski J, Wessner D. A short assessment of sublingual immunotherapy. Int Arch Allergy Immunol. 2001;126:185–187
  9. Quirino T, Iemoli E, Siciliani E, Parmiani S, Milazzo F. Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study. Clin Exp Allergy. 1996;26:1253–1261
  10. Clavel R, Bousquet J, Andre C. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy. 1998;53:493–498
  11. Passalacqua G, Albano M, Riccio A, Fregonese L, Puccinelli P, Parmiani S, et al. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: a double-blind, placebo-controlled trial. J Allergy Clin Immunol. 1999;104:964–968
  12. Di Rienzo V, Puccinelli P, Frati F, Parmiani S. Grass pollen specific sublingual/swallow immunotherapy in children: open-controlled comparison among different treatment protocols. Allergol Immunopathol (Madr). 1999;27:145–151
  13. Valle C, Bazzi S, Berra D, Sillano V, Puccinelli P, Parmiani S. Effects of sublingual immunotherapy in patients sensitised to Ambrosia. An open controlled study. Allergol Immunopathol (Madr). 2000;28:311–317
  14. Nelson HS, Oppenheimer J, Vatsia GA, Buchmeier A. A double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized cat extract. J Allergy Clin Immunol. 1993;92:229–236
  15. La Rosa M, Ranno C, Andre C, Carat F, Tosca MA, Canonica GW. Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 1999;104:425–432
  16. Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T, Andre C, et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy. 1998;53:662–672
  17. Horak F, Stubner P, Berger UE, Marks B, Toth J, Jager S. Immunotherapy with sublingual birch pollen extract. A short-term double-blind placebo study. J Invest Allergol Clin Immunol. 1998;8:165–171
  18. Purello-D’Ambrosio F, Gangemi S, Isola S, La Motta N, Puccinelli P, Parmiani S, et al. Sublingual immunotherapy: a double-blind, placebo-controlled trial with Parietaria judaica extract standardized in mass units in patients with rhinoconjunctivitis, asthma, or both. Allergy. 1999;54:968–973
  19. Guez S, Vatrinet C, Fadel R, Andre C. House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy. 2000;55:369–375
  20. Bousquet J, Scheinmann P, Guinnepain MT, Perrin-Fayolle M, Sauvaget J, Tonnel AB, et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy. 1999;54:249–260
  21. Pajno GB, Morabito L, Barberio G, Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy. 2000;55:842–849
  22. Pajno GB, Vita D, Caminiti D, Parmiani S, BArberio G. Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionate. Clin Exp Allergy. 2003;33:1641–1647
  23. Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T, et al. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy. 2004;59:498–504
  24. Rolinck-Werninghaus C, Wolf H, Liebke C, Baars JC, Lange J, Kopp MV, et al. A prospective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen. Allergy. 2004;59:1285–1293
  25. Bahceciler NN, Isik U, Barlan IB, Basaran MM. Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. Pediatr Pulmonol. 2001;32:49–55
  26. Frew AJ, Smith HE. Sublingual immunotherapy. J Allergy Clin Immunol. 2001;107:441–444

PII: S0954-6111(05)00506-8

doi: 10.1016/j.rmed.2005.11.016

Respiratory Medicine
Volume 100, Issue 8 , Pages 1374-1383 , August 2006