Respiratory Medicine
Volume 101, Issue 5 , Pages 951-956 , May 2007

Deep inspiration-induced changes in lung volume decrease with severity of asthma

  • Nicola Scichilone

      Affiliations

    • Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell’Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +390916802766; fax: +390916891857.
    • ,
  • Roberto Marchese

      Affiliations

    • Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell’Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy
    • ,
  • Simona Soresi

      Affiliations

    • Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell’Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy
    • ,
  • Amelia Interrante

      Affiliations

    • Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell’Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy
    • ,
  • Alkis Togias

      Affiliations

    • Division of Allergy and Clinical Immunology, and Division of Respiratory and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, 21224 Bayview Circle, Baltimore, Maryland, USA
    • Participation in this work was supported by NIH Grant RO1 HL61277.
    • ,
  • Vincenzo Bellia

      Affiliations

    • Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell’Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy

Received 21 January 2006 ,Accepted 9 September 2006.

References 

  1. Brusasco V, Crimi E, Barisione G, Spanevello A, Rodarte JR, Pellegrino R. Airway responsiveness to methacholine: effects of deep inhalations and airway inflammation. J Appl Physiol. 1999;87(2):567–573
  2. Crimi E, Pellegrino R, Milanese M, Brusasco V. Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects. J Appl Physiol. 2002;93(4):1384–1390
  3. Jensen A, Atileh H, Suki B, Ingenito EP, Lutchen KR. Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations. J Appl Physiol. 2001;91(1):506–515discussion 504–5
  4. King GG, Moore BJ, Seow CY, Pare PD. Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge. Am J Respir Crit Care Med. 1999;160(2):454–457
  5. Scichilone N, Kapsali T, Permutt S, Togias A. Deep inspiration-induced bronchoprotection is stronger than bronchodilation. Am J Respir Crit Care Med. 2000;162(3 Pt 1):910–916
  6. Sundblad BM, Larsson K. Effect of deep inhalations after a bronchial methacholine provocation in asthmatic and non-asthmatic subjects. Respir Med. 2002;96(7):477–481
  7. Scichilone N, Permutt S, Togias A. The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness. Am J Respir Crit Care Med. 2001;163(2):413–419
  8. Orehek J, Charpin D, Velardocchio J, Grimaud C. Bronchomotor effect of a bronchoconstriction-induced deep inspiration in asthmatics. Am Rev Respir Dis. 1980;121:297–305
  9. Assefa D, Amin N, Dozor AJ. Effect of deep inspiration on airway caliber in children with asthma. Pediatr Pulmonol. 2004;38(5):406–412
  10. Scichilone N, Marchese R, Catalano F, Togias A, Vignola AM, Bellia V. The bronchodilatory effect of deep inspiration diminishes with aging. Respir Med. 2004;98(9):838–843
  11. Scichilone N, Marchese R, Catalano F, Vignola AM, Togias A, Bellia V. Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD. Chest. 2004;125(6):2029–2035
  12. Scichilone N, Permutt S, Bellia V, Togias A. Inhaled corticosteroids and the beneficial effect of deep inspiration in asthma. Am J Respir Crit Care Med. 2005;172(6):693–699
  13. Methodology and summary of new recommendations global strategy for asthma management and prevention: 2004 update. 〈http://www.ginasthma.org〉 2004.
  14. Juniper EF, O’Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14(4):902–907
  15. Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med. 1995;152(3):1107–1136
  16. Jackson AC, Murphy MM, Rassulo J, Celli BR, Ingram RH. Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects. J Appl Physiol. 2004;96(1):137–142
  17. King GG, Moore BJ, Seow CY, Pare PD. Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics. Am J Respir Crit Care Med. 2001;164(2):216–218
  18. Lutchen KR, Jensen A, Atileh H, et al. Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med. 2001;164(2):207–215
  19. Wheatley JR, Pare PD, Engel LA. Reversibility of induced bronchoconstriction by deep inspiration in asthmatic and normal subjects. Eur Respir J. 1989;2(4):331–339
  20. Lim TK, Pride NB, Ingram RH. Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma. Am Rev Respir Dis. 1987;135(3):591–596
  21. Pyrgos G, Scichilone N, Mintz M, Permutt S, Togias A, Brown R. Deep inspiration-induced bronchodilation in asthma is dependent on airways distensibility assessed by HRCT. Am J Respir Crit Care Med. 2001;163:A830
  22. Gelb AF, Licuanan J, Shinar CM, Zamel N. Unsuspected loss of lung elastic recoil in chronic persistent asthma. Chest. 2002;121(3):715–721
  23. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001;164(10 Part 2):S28–S38
  24. Shore SA. Direct effects of Th2 cytokines on airway smooth muscle. Curr Opin Pharmacol. 2004;4(3):235–240
  25. Bel EH, Timmers MC, Zwinderman AH, Dijkman JH, Sterk PJ. The effect of inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in asthmatic subjects. Am Rev Respir Dis. 1991;143(1):109–113
  26. Corsico A, Pellegrino R, Zoia MC, Barbano L, Brusasco V, Cerveri I. Effects of inhaled steroids on methacholine-induced bronchoconstriction and gas trapping in mild asthma. Eur Respir J. 2000;15(4):687–692

☆ None of the authors are involved with organizations with financial interest in the subject matter.

PII: S0954-6111(06)00454-9

doi: 10.1016/j.rmed.2006.09.009

Respiratory Medicine
Volume 101, Issue 5 , Pages 951-956 , May 2007

Article Tools

* Image Usage & Resolution