Respiratory Medicine
Volume 101, Issue 5 , Pages 938-943 , May 2007

Transforming growth factor-β1 polymorphisms, airway responsiveness and lung function decline in smokers

  • Emiko Ogawa

      Affiliations

    • James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
  • ,
  • Jian Ruan

      Affiliations

    • James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
  • ,
  • John E. Connett

      Affiliations

    • Division of Biostatistics, School of Public Health, University of Minnesota, MN, USA
  • ,
  • Nicholas R. Anthonisen

      Affiliations

    • Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
  • ,
  • Peter D. Paré

      Affiliations

    • James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
  • ,
  • Andrew J. Sandford

      Affiliations

    • James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    • Corresponding Author InformationCorresponding author. Tel.: +16048069008; fax: +16048068351.

Received 10 January 2006 ,Accepted 10 September 2006.

References 

  1. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2001;34:50s–59s
  2. Cosio M, Ghezzo H, Hogg JC, et al. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med. 1978;298:1277–1281
  3. Bosken CH, Wiggs BR, Paré PD, Hogg JC. Small airway dimensions in smokers with obstruction to airflow. Am Rev Respir Dis. 1990;142:563–570
  4. Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J. 1977;1:1645–1648
  5. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163:1256–1276
  6. Silverman EK, Chapman HA, Drazen JM, et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease: risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998;157:1770–1778
  7. Widom RL. Regulation of matrix biosynthesis and degradation in systemic sclerosis. Curr Opin Rheumatol. 2000;12:534–539
  8. de Boer WI, van Schadewijk A, Sont JK, et al. Transforming growth factor β1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158:1951–1957
  9. Kunimoto DY, Ritzel M, Tsang M. The roles of IL-4, TGF-beta and LPS in IgA switching. Eur Cytokine Network. 1992;3:407–415
  10. Takizawa H, Tanaka M, Takami K, et al. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2001;163:1476–1483
  11. Morris DG, Huang X, Kaminski N, et al. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003;422:169–173
  12. Wu L, Chau J, Young RP, et al. Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease. Thorax. 2004;59:126–129
  13. Celedon JC, Lange C, Raby BA, et al. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004;13:1649–1656
  14. Derynck R, Jarrett JA, Chen EY, et al. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 1985;316:701–705
  15. Kim SJ, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-beta1 gene. J Biol Chem. 1989;264:402–408
  16. Connett JE, Kusek JW, Bailey WC, O’ Hara P, Wu M. Design of the Lung Health Study: a randomized clinical trial of early intervention for chronic obstructive pulmonary disease. Controlled Clin Trials. 1993;14:3S–19S
  17. Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study. JAMA. 1994;272:1497–1505
  18. O’Connor GT, Sparrow D, Weiss ST. A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. Am J Respir Crit Care Med. 1995;152:87–92
  19. Ohtsuka T, Yamakage A, Yamazaki S. The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis. Br J Dermatol. 2002;147:458–463
  20. Schneider S, Roessli D, Excoffier L. Arlequin ver. 2.000: a software for population genetics data analysis. Switzerland: Genetics and Biometry Laboratory, University of Geneva; 2000;
  21. Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L. Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med. 1998;158:1958–1962
  22. Silverman ES, Palmer LJ, Subramaniam V, et al. Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med. 2004;169:214–219
  23. Pulleyn LJ, Newton R, Adcock IM, Barnes PJ. TGF beta1 allele association with asthma severity. Hum Genet. 2001;109:623–627
  24. Grainger DJ, Heathcote K, Chiano M, et al. Genetic control of the circulating concentration of transforming growth factor type β1. Hum Mol Genet. 1999;8:93–97
  25. Yamada Y, Miyauchi A, Goto J, et al. Association of a polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res. 1998;13:1569–1576
  26. Suthanthiran M, Li B, Song JO, et al. Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: a novel mediator of hypertension and/or target organ damage. Proc Natl Acad Sci USA. 2000;97:3479–3484
  27. Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation. 1998;66:1014–1020
  28. Arkwright PD, Laurie S, Super M, et al. TGF-β1 genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax. 2000;55:459–462
  29. Su ZG, Wen FQ, Feng YL, Xiao M, Wu XL. Transforming growth factor-beta1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population. Acta Pharmacol Sin. 2005;26:714–720
  30. Rijcken B, Schouten JP, Xu X, Rosner B, Weiss ST. Airway hyperresponsiveness to histamine associated with accelerated decline in FEV1. Am J Respir Crit Care Med. 1995;151:1377–1382

 This study was supported by grants from the British Columbia Lung Association, the Canadian Institutes of Health Research and National Institutes of Heath Grant 5R01HL064068-04. The Lung Health Study was supported by Contract N01-HR-46002 from the Division of Lung Diseases of the National Heart, Lung, and Blood Institute.

PII: S0954-6111(06)00455-0

doi: 10.1016/j.rmed.2006.09.008

Respiratory Medicine
Volume 101, Issue 5 , Pages 938-943 , May 2007