Respiratory Medicine
Volume 101, Issue 10 , Pages 2217-2220 , October 2007

Changing pattern of sputum cell counts during successive exacerbations of airway disease

  • Liesel D'silva

      Affiliations

    • Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ont., Canada L8N 4A6
    • ,
  • Richard J. Cook

      Affiliations

    • Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ont., Canada L8N 4A6
    • Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ont., Canada N2L 3G1
    • ,
  • Christopher J. Allen

      Affiliations

    • Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ont., Canada L8N 4A6
    • ,
  • Frederick E. Hargreave

      Affiliations

    • Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ont., Canada L8N 4A6
    • ,
  • Krishnan Parameswaran

      Affiliations

    • Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ont., Canada L8N 4A6
    • Corresponding Author InformationCorresponding author. Tel.: +9055221155x35044; fax: +9055216183.

Received 12 February 2007 ,Accepted 15 May 2007.

References 

  1. Wedzicha JA, Wilkinson T. Impact of chronic obstructive pulmonary disease exacerbations on patients and payers. Proc Am Thorac Soc. 2006;3:218–221
  2. Rodrigo GJ, Rodrigo C, Hall JB. Acute asthma in adults: a review. Chest. 2004;125:1081–1102
  3. Jayaram L, Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J. 2006;27:483–494
  4. Papi A, Bellettato CM, Braccioni F, et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med. 2006;173:1114–1121
  5. Wark PA, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J. 2002;19:68–75
  6. Parameswaran K, Watson R, Gauvreau GM, Sehmi R, O’Byrne PM. The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma. Am J Respir Crit Care Med. 2004;169:915–920
  7. Lemiere C, Romeo P, Chaboillez S, Tremblay C, Malo JL. Airway inflammation and functional changes after exposure to different concentrations of isocyanates. J Allergy Clin Immunol. 2002;110:641–646
  8. Brightling CE, Ward R, Wardlaw AJ, Pavord ID. Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J. 2000;15:682–686
  9. Pizzichini MM, Pizzichini E, Clelland L, Efthimiadis A, Pavord I, Dolovich J. Prednisone-dependent asthma: inflammatory indices in induced sputum. Eur Respir J. 1999;13:15–21
  10. Berlyne GS, Efthimiadis A, Hussack P, Groves D, Dolovich J, Hargreave FE. Sputum in asthma: color versus cell counts. J Allergy Clin Immunol. 2000;105:182–183
  11. Leigh R, Pizzichini MM, Morris MM, Maltais F, Hargreave FE, Pizzichini E. Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J. 2006;27:964–971
  12. Pizzichini E, Pizzichini MM, Efthimiadis A, Hargreave FE, Dolovich J. Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination. Eur Respir J. 1996;9:1174–1180
  13. Lawless JF, Wigg MB, Tuli S, et al. Analysis of repeated failures or durations, with application to shunt failures for patients with paediatric hydrocephalus. Appl Stat. 2001;50:449–465
  14. Parameswaran K. Treatment strategy for asthma: one for all and all for one?. Chest. 2006;129:221–223
  15. Parameswaran K, Pizzichini E, Pizzichini MM, Hussack P, Efthimiadis A, Hargreave FE. Clinical judgement of airway inflammation versus sputum cell counts in patients with asthma. Eur Respir J. 2000;15:486–490
  16. Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160:1001–1008
  17. Di Franco A, Bartoli ML, Carnevali S, et al. Analysis of sputum cell counts during spontaneous moderate exacerbations of asthma in comparison to the stable phase. J Asthma. 2003;40:155–162
  18. Turner MO, Hussack P, Sears MR, Dolovich J, Hargreave FE. Exacerbations of asthma without sputum eosinophilia. Thorax. 1995;50:1057–1061
  19. Gibson PG, Norzila MZ, Fakes K, Simpson J, Henry RL. Pattern of airway inflammation and its determinants in children with acute severe asthma. Pediatr Pulmonol. 1999;28:261–270
  20. Mercer PF, Shute JK, Bhowmik A, Donaldson GC, Wedzicha JA, Warner JA. MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. Respir Res. 2005;6:151
  21. European Network for Understanding Mechanisms of Severe Asthma. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J. 2003;22:470–477
  22. Pizzichini E, Pizzichini MM, Efthimiadis A, Hargreave FE, Dolovich J. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med. 1996;154:308–317
  23. Seemungal TA, Donaldson GC, Bhowmik A, Jeffries DJ, Wedzicha JA. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:1608–1613
  24. Siva R, Green RH, Brightling CE, et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur Respir J. 2007;29:906–913

PII: S0954-6111(07)00214-4

doi: 10.1016/j.rmed.2007.05.010

Respiratory Medicine
Volume 101, Issue 10 , Pages 2217-2220 , October 2007

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