Respiratory Medicine
Volume 102, Issue 9 , Pages 1296-1304 , September 2008

Double-blind, placebo-controlled evaluation of grass pollen specific immunotherapy with oral drops administered sublingually or supralingually

  • P. Panzner

      Affiliations

    • Department of Immunology and Allergology, Charles University, Medical Faculty in Pilsen, Alej Svobody 80, 32300 Plzen, Czech Republic
    • Corresponding Author InformationCorresponding author. Tel.: +420 377 104 343; fax: +420 377 103 397.
    • ,
  • M. Petráš

      Affiliations

    • Sevapharma a.s., Prague, Czech Republic
    • ,
  • T. Sýkora

      Affiliations

    • Internal medicine and Allergology Office, Pardubice, Czech Republic
    • ,
  • I. Lesná

      Affiliations

    • Sevapharma a.s., Prague, Czech Republic

Received 17 October 2006 ,Accepted 28 March 2008.

References 

  1. Bousquet J, Lockey RF, Malling H-J. WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy. 1998;53(Suppl.):1–42
  2. Fanta C, Bohle B, Hirt W, Siemann U, Horak F, Kraft D, et al. Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol. 1999;120:218–224
  3. Passalacqua G, Albano M, Riccio A, Fregonese L, Puccinelli P, Parmiani S, et al. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: a double-blind, placebo-controlled trial. J Allergy Clin Immunol. 1999;104:964–968
  4. Purello-D'Ambrosio F, Gangemi S, Isola S, La Motta N, Puccinelli P, Parmiani S, et al. Sublingual immunotherapy: a double-blind, placebo-controlled trial with Parietaria judaica extract standardized in mass units in patients with rhinoconjunctivitis, asthma, or both. Allergy. 1999;54:968–973
  5. Pradalier A, Basset D, Claudel A, Couturier P, Wessel F, Galvain S, et al. Sublingual-swallow immunotherapy (SLIT) with a standardized five-grass–pollen extract (drops and sublingual tablets) versus placebo in seasonal rhinitis. Allergy. 1999;54:819–828
  6. Di Rienzo V, Puccinelli P, Frati F, Parmiani S. Grass pollen specific sublingual/swallow immunotherapy in children: open-controlled comparison among different treatment protocols. Allergol Immunopathol (Madr). 1999;27:145–151
  7. Hordijk GJ, Antvelink JB, Luwema RA. Sublingual immunotherapy with a standardised grass pollen extract; a double-blind placebo-controlled study. Allergol Immunopathol (Madr). 1998;26:234–240
  8. Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T, Andre C, et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy. 1998;53:662–672
  9. Clavel R, Bousquet J, Andre C. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy. 1998;53:493–498
  10. Quirino T, Iemoli E, Siciliani E, Parmiani S, Milazzo F. Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study. Clin Exp Allergy. 1996;26:1253–1261
  11. Purello-D'ambrosio FP, Ricciardi L, Isola S, Puccinelli P, Musarra A. Rush sublingual immunotherapy in Parietaria allergic patients. Allergol Immunopathol (Madr). 1996;21:146–151
  12. Sabbah A, Hassoun S, Le Sellin J, Andre C, Sicard H. A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy. 1994;49:309–313
  13. Wilson DR, Torres Lima M, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60:4–12
  14. Malling Hans-Jorgen. Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results. Curr Opin Allergy Clin Immunol. 2004;4:539–542
  15. Smith H, White P, Annila I, Poole J, Andre C, Frew A. Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis. J Allergy Clin Immunol. 2004;114:831–837
  16. D'Amato G, Spieksma FthM, Liccardi G, Jäger S, Russo M, Kontou-Fili K, et al. Position paper. Pollen-related allergy in Europe. Allergy. 1998;53:567–585

PII: S0954-6111(08)00135-2

doi: 10.1016/j.rmed.2008.03.024

Respiratory Medicine
Volume 102, Issue 9 , Pages 1296-1304 , September 2008

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