Respiratory Medicine
Volume 102, Issue 12 , Pages 1701-1707 , December 2008

Rational timing of combination therapy with tiotropium and formoterol in moderate and severe COPD

  • Claudio Terzano

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy
    • ,
  • Angelo Petroianni

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 06 4074517; fax: +39 06 40800276.
    • ,
  • Vittoria Conti

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy
    • ,
  • Daniela Ceccarelli

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy
    • ,
  • Elda Graziani

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy
    • ,
  • Alessandro Sanduzzi

      Affiliations

    • Institute of Respiratory Diseases, II Faculty of Medicine, University of Naples, Italy
    • ,
  • Serena D'Avelli

      Affiliations

    • Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, “Sapienza” University of Rome, Via Casal de' Pazzi, 16, 00156 Rome, Italy

Received 22 January 2008 ,Accepted 14 July 2008.

References 

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  18. Dahl R, Greefhorst LA, Nowak D, Nonikov V, Byrne AM, Thomson MH, et al. Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:778–784
  19. Aalbers R, Ayres J, Backer V, Decramer M, Lier PA, Magyar P, et al. Formoterol in patients with chronic obstructive pulmonary disease: a randomized, controlled, 3-month trial. Eur Respir J. 2002;19:936–943
  20. Postma DS, Keyzer JJ, Koëter GH, Sluiter HJ, De Vries K. Influence of the parasympathetic and sympathetic nervous system on nocturnal bronchial obstruction. Clin Sci (Lond). 1985;69:251–258
  21. Donohue JF, Kotch A, Menjoge SS, Witek TJ, Kesten S. Circadian patterns of rescue b2-agonist use in COPD. Eur Respir J. 2000;16(Suppl. 31):56s

PII: S0954-6111(08)00253-9

doi: 10.1016/j.rmed.2008.07.012

Respiratory Medicine
Volume 102, Issue 12 , Pages 1701-1707 , December 2008

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