Respiratory Medicine
Volume 103, Issue 7 , Pages 1083-1089 , July 2009

Elevated plasma TGF-β1 levels in patients with chronic obstructive pulmonary disease

  • Judith C.W. Mak

      Affiliations

    • Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • Corresponding Author InformationCorresponding author. Room 804, Administration Block, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China. Tel.: +86 852 2855 5886; fax: +86 852 2904 9443.
    • ,
  • Moira M.W. Chan-Yeung

      Affiliations

    • Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Siu P. Ho

      Affiliations

    • Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Kin S. Chan

      Affiliations

    • Department of Pulmonary Medicine, Haven of Hope Hospital, Hong Kong SAR, China
    • ,
  • Kahlin Choo

      Affiliations

    • Department of Medicine, North District Hospital, Hong Kong SAR, China
    • ,
  • Kwok S. Yee

      Affiliations

    • Department of Medicine, Kwong Wah Hospital, Hong Kong SAR, China
    • ,
  • Chi H. Chau

      Affiliations

    • Department of Tuberculosis and Chest Medicine, The Grantham Hospital, Hong Kong SAR, China
    • ,
  • Amy H.K. Cheung

      Affiliations

    • Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Mary S.M. Ip

      Affiliations

    • Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Members of the Hong Kong Thoracic Society COPD Study Group

Received 2 December 2008 ,Accepted 6 January 2009.

References 

  1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020. Global burden of disease study. Lancet. 1997;349:1498–1504
  2. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive pulmonary disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001;163:1256–1276
  3. Sethi JM, Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med. 2000;21:67–86
  4. Lokke A, Lange P, Scharling H, Fabricius P, Vestbo J. Developing COPD: a 25 year follow up study of the general population. Thorax. 2006;61:935–939
  5. Letterio JJ, Roberts AB. Regulation of immune responses by transforming growth factor-β. Annu Rev Immunol. 1998;16:137–161
  6. Sime PJ, Xing Z, Graham FL, Csaky KG, Gaulkie J. Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung. J Clin Invest. 1997;100:768–776
  7. Hansen G, McIntire JJ, Yeung VP, et al. CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest. 2000;105:61–70
  8. Vignola AM, Chanez P, Chiappara G, et al. Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med. 1997;156:591–599
  9. Takizawa H, Tanaka M, Takami K, et al. Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2001;163:1476–1483
  10. Kokturk N, Tatlicioglu T, Memis L, Akyurek N, Akyol G. Expression of transforming growth factor-β1 in bronchial biopsies in asthma and COPD. J Asthma. 2003;40:887–893
  11. Barthelemy-Brichant N, David JL, Bosquee L, et al. Increased TGF-β1 plasma level in patients with lung cancer: potential mechanisms. Eur J Clin Invest. 2002;32:193–198
  12. Higashimoto Y, Yamagata Y, Taya S, et al. Systemic inflammation in chronic obstructive pulmonary disease and asthma: similarities and differences. Respirology. 2008;13:128–133
  13. Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnot PJ, Hutchinson IV. Genotypic variation in the transforming growth factor-β1 gene: association with transforming growth factor-β1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation. 1998;66:1014–1020
  14. Grainger DJ, Heathcote K, Chiano M, et al. Genetic control of the circulating concentration of transforming growth factor type β1. Hum Mol Genet. 1999;8:93–97
  15. Fujii D, Brissenden J, Derynck R, Francke U. Transforming growth factor-β gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet. 1986;12:281–288
  16. Watanabe Y, Kinoshita A, Yamada T, et al. A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-β1 (TGF-β1) and its signaling pathway. J Hum Genet. 2002;47:478–483
  17. Celedon JC, Lange C, Raby BA, et al. The transforming growth factor-β1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004;13:1649–1656
  18. Wu L, Chau J, Young RP, et al. Transforming growth factor-β1 genotype and susceptibility to chronic obstructive pulmonary disease. Thorax. 2004;59:126–129
  19. Su Z-G, Wen F-Q, Feng Y-L, Xiao M, Wu X-L. Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population. Acta Pharmacol Sin. 2005;26:714–720
  20. Yoon HI, Silverman EK, Lee HW, et al. Lack of association between COPD and transforming growth factor-beta1 (TGFβ1) genetic polymorphisms in Koreans. Int J Tuberc Lung Dis. 2006;10:504–509
  21. Global Initiative for Chronic Obstructive Lung Disease (GOLD) . Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. [updated 2007]. Available on line at: www.goldcopd.com2007;
  22. Ip MS, Ko FW, Lau AC, et al. Updated spirometric reference values for adult Chinese in Hong Kong and implications on clinical utilization. Chest. 2006;129:384–392
  23. Standardization of spirometry. 1994 Update. American Thoracic Society Am J Respir Crit Care Med. 1995;152:1107–1136
  24. Ogawa E, Ruan J, Connett JE, Anthonisen NR, Pare PD, Sandford AJ. Transforming growth factor-β1 polymorphisms, airway responsiveness and lung function decline in smokers. Respir Med. 2007;101:938–943
  25. Purcell S, Cherny SS, Sham PC. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics. 2003;19:149–150
  26. Nagpal K, Sharma S, B-Rao C, et al. TGF-β1 haplotypes and asthma in Indian populations. J Allergy Clin Immunol. 2005;115:527–533
  27. Yokota M, Ichihara S, Lin TL, Nakashima N, Yamada Y. Association of a T29 → C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese. Circulation. 2000;101:2783–2787
  28. Perrey C, Pravica V, Sinnott PJ, Hutchinson IV. Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factor-alpha genes: a technical report. Transpl Immunol. 1998;6:193–197
  29. Morris DG, Huang X, Kaminski N, et al. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp 12-dependent emphysema. Nature. 2003;422:169–173
  30. Rahman I, van Schadewijk AA, Crowther AJ, et al. 4-Hydroxy-2-nonenal, a specific lipid peroxiation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166:490–495
  31. Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev. 2000;14:163–176
  32. Lanone S, Zheng T, Zhu Z, et al. Overlapping and enzyme-specific contributions of matrix metalloproteinase-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002;110:463–474
  33. Ning W, Lee J, Kaminski N, et al. Comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD. Proc Am Thorac Soc. 2006;3:466
  34. Arkwright PA, Laurie S, Super M, et al. TGF-β1 genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax. 2000;55:459–462
  35. Lee JG, Ahn C, Yoon SC, et al. No association of the TGF-β1 gene polymorphisms with the renal progression in autosomal dominant polycystic kidney disease (ADPKD) patients. Clin Nephrol. 2003;59:10–16
  36. Suzuki S, Tanaka Y, Orito E, et al. Transforming growth factor-β1 genetic polymorphism in Japanese patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2003;18:1139–1143
  37. Wang H, Mengsteab S, Tag CG, et al. Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection. World J Gastroenterol. 2005;11:1929–1936
  38. Okamoto Y, Gotoh Y, Uemura O, Tanaka S, Ando T, Nishida M. Age-dependent decrease in serum transforming growth factor (TGF)-beta 1 in healthy Japanese individuals; population study of serum TGF-beta 1 level in Japanese. Dis Markers. 2005;21:71–74

PII: S0954-6111(09)00013-4

doi: 10.1016/j.rmed.2009.01.005

Respiratory Medicine
Volume 103, Issue 7 , Pages 1083-1089 , July 2009

Article Tools

* Image Usage & Resolution