Respiratory Medicine
Volume 103, Issue 7 , Pages 1025-1032 , July 2009

Induced sputum eosinophilia in ulcerative colitis patients: The lung as a mirror image of intestine?

  • Elizabeth Fireman

      Affiliations

    • Department of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv 64239, Israel
    • Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972 3 3988; fax: +972 3 4601.
    • ,
  • Farid Masarwy

      Affiliations

    • Department of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
    • Bruce Rappaport Faculty of Medicine, The Technion, Haifa, Israel
    • ,
  • Gabi Groisman

      Affiliations

    • Bruce Rappaport Faculty of Medicine, The Technion, Haifa, Israel
    • Department of Pathology, Hillel Yaffe Medical Center, Hadera, Israel
    • ,
  • Moshe Shtark

      Affiliations

    • Department of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv 64239, Israel
    • Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel
    • ,
  • Yael Kopelman

      Affiliations

    • Department of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
    • Bruce Rappaport Faculty of Medicine, The Technion, Haifa, Israel
    • ,
  • Shmuel Kivity

      Affiliations

    • Department of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv 64239, Israel
    • Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel
    • ,
  • Zvi Fireman

      Affiliations

    • Department of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
    • Bruce Rappaport Faculty of Medicine, The Technion, Haifa, Israel

Received 15 October 2008 ,Accepted 15 January 2009.

References 

  1. Regueiro MD. Diagnosis and treatment of ulcerative proctitis. J Clin Gastroenterol. 2004;38:733–740
  2. Danese S, Semeraro S, Papa A, et al. Extraintestinal manifestations in inflammatory bowel disease. World J Gastroenterol. 2005;11:7227–7236
  3. Tzanakis N, Bouros D, Samiou M, et al. Lung function in patients with inflammatory bowel disease. Respir Med. 1998;92:516–522
  4. Heatley RV, Thomas P, Prokipchuk EJ, Gauldie J, Sieniewicz DJ, Bienenstock J. Pulmonary function abnormalities in patients with inflammatory bowel disease. Q J Med. 1982;203:241–250
  5. Mohamed-Hussein AA, Mohamed NA, Ibrahim ME. Changes in pulmonary function in patients with ulcerative colitis. Respir Med. 2007;101:977–982
  6. Bonniere P, Wallaert B, Cortot A, et al. Latent pulmonary involvement in Crohn's disease: biological, functional, bronchoalveolar lavage and scintigraphic studies. Gut. 1986;27:919–925
  7. Karadag F, Ozhan MH, Akçiçek E, Günel O, Alper H, Veral A. Is it possible to detect ulcerative colitis-related respiratory syndrome early?. Respirology. 2001;6:341–346
  8. James D, Rizzato G. Bronchopulmonary lavage (BAL): a window of the lungs. Sarcoidosis. 1992;9:3–14
  9. Fireman E. Induced sputum: opening a new window to the lung. Sarcoidosis Vasc Diffuse Lung Dis. 2001;18:263–271[Review]
  10. Fireman Z, Osipov A, Kivity S, et al. The use of induced sputum in the assessment of pulmonary involvement in Crohn's disease. Am J Gastroenterol. 2000;95:730–734
  11. Louis E, Louis R, Shute J, et al. Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease. Clin Exp Allergy. 1999;29:660–666
  12. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel diseases. Nat Rev Immunol. 2003;3:521–533
  13. D'Haens G, Sandborn WJ, Feagan BG, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology. 2007;132:763–786
  14. Truelove SC, Witts LJ. Cortisone in ulcerative colitis: final report on therapeutic trial. Br Med J. 1955;2:1041–1047
  15. Miller MR, Hankinson J, Brusasco V, et al. ATS/ERS Task Force. ATS/ERS standardization of lung function testing: standardization of spirometry. Eur Respir J. 2005;26:319–338
  16. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax. 1992;47:25–29
  17. Popov T, Gottschalk R, Kolendowicz R, Dolovich J, Powers P, Hargreave FE. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy. 1994;24:778–783
  18. Li CI, Yam LT, Crossby WH. Histochemical characterization of cellular and structural elements of the human spleen. J Histochem Cytochem. 1972;20:1049–1058
  19. Dignass AU, Baumgart DC, Sturm A. The aetiopathogenesis of inflammatory bowel disease – immunology and repair mechanisms. Aliment Pharmacol Ther. 2004;209(Suppl. 4):9–17
  20. Allez M, Mayer L. Regulatory T cells – peace keepers in the gut. Inflamm Bowel Dis. 2004;10:666–676
  21. Pabst R, Tschering T. Lymphocyte dynamics: caution in interpreting BAL numbers. Thorax. 1997;52:1078–1080
  22. Carvalho AT, Elia CC, De Souza HS, et al. Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease. J Clin Gastroenterol. 2003;36:120–125
  23. Rutgers SR, Timens W, Kaufmann HF, van der Mark TW, Koëter GH, Postma DS. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J. 2000;15:109–115
  24. Wallaert B, Desreumaux P, Copin M. Immunoreactivity of interleukin-3 and -5 and granulocyte/macrophage colony stimulating factor of intestinal mucosa in bronchial asthma. J Exp Med. 1995;182:1898–1904
  25. Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal eosinophils. Immunol Rev. 2001;179:139–155
  26. Bischoff SC, Wedemeyer J, Herrmann A, et al. Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease. Histopathology. 1996;28:1–13
  27. Carlson M, Raab Y, Peterson C, Hällgren R, Venge P. Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion. Am J Gastroenterol. 1999;94:1876–1883
  28. Peterson CG, Eklund E, Taha Y, Raab Y, Carlson M. A new method for the quantification of neutrophil and eosinophil cationic proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease. Am J Gastroenterol. 2002;97:1755–1762
  29. Bousquet J, Chanez P, Lacoste J. Eosinophilic inflammation in asthma. N Engl J Med. 1990;323:1033–1039
  30. Hargreave FE, Leigh R. Induced sputum, eosinophilic bronchitis, and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160:S53–S57
  31. Brightling CE. Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl.):116S–121S
  32. Fireman E, Boikaner T, Priel IE. Combined CD4/CD8 ratio in induced sputum and pulmonary function testing for non-invasive identification of sarcoidosis. Transl Res. 2006;148:87–95
  33. Rothenberg ME, Hogan SP. The eosinophils. Annu Rev Immunol. 2006;24:147–174
  34. Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keogh BA. Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. N Engl J Med. 1984;310:235–244
  35. Yaffe B, Korelitz B. Sulfasalazine pneumonitis. Am J Gastroenterol. 1983;78:493–494
  36. Kelly MM, Leigh R, Jayaram L, Goldsmith CH, Parameswaran K, Hargreave FE. Eosinophilic bronchitis in asthma: a model for establishing dose–response and relative potency of inhaled corticosteroids. Allergy Clin Immunol. 2006;117:989–994
  37. Lampinen M, Backman M, Winqvist O, et al. Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. J Leukoc Biol. 2008 Sep 18;[Epub ahead of print]
  38. Al-Haddad S, Riddell RH. The role of eosinophils in inflammatory bowel disease. Gut. 2005;54:1674–1675
  39. Sarin SK, Malhotra V, Sen Gupta S, Karol A, Gaur SK, Anand BS. Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis. A prospective controlled study. Dig Dis Sci. 1987;32:363–367
  40. Jeziorska M, Haboubi N, Schofield P, Woolley DE. Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique. J Pathol. 2001;194:484–492
  41. Korelitz BI, Sommers SC. Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and mucosal cell counts. Am J Dig Dis. 1976;21:441–444
  42. Lampinen M, Rönnblom A, Amin K, et al. Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut. 2005;54:1714–1720
  43. Phipps S, Ying S, Wangoo A, Ong YE, Levi-Schaffer F, Kay AB. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J Immunol. 2002;169:4604–4612

PII: S0954-6111(09)00031-6

doi: 10.1016/j.rmed.2009.01.016

Respiratory Medicine
Volume 103, Issue 7 , Pages 1025-1032 , July 2009

Article Tools

* Image Usage & Resolution