Respiratory Medicine
Volume 103, Issue 8 , Pages 1167-1173 , August 2009

Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution

  • Tjalling W. de Vries

      Affiliations

    • Department of Paediatrics, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR Leeuwarden, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 58 2863385; fax: +31 58 2863390.
    • ,
  • Bart L. Rottier

      Affiliations

    • Beatrix Children's Hospital, Division of Paediatric Pulmonology and Allergology, University Hospital Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    • ,
  • Doetie Gjaltema

      Affiliations

    • Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands
    • ,
  • Paul Hagedoorn

      Affiliations

    • Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands
    • ,
  • Henderik W. Frijlink

      Affiliations

    • Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands
    • ,
  • Anne H. de Boer

      Affiliations

    • Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands

Received 27 September 2008 ,Accepted 14 February 2009.

References 

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  6. Gabrio BJ, Stein SW, Velasquez DJ. A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int J Pharm. 1999;186:3–12
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  11. Asmus MJ, Liang J, Coowanitwong I, Vafadari R, Hochhaus G. In vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers. Ann Allergy Asthma Immunol. 2002;88:204–208
  12. Asmus MJ, Coowanitwong I, Kwon SH, Khorsand N, Hochhaus G. In vitro performance of two common valved holding chambers with a chlorofluorocarbon-free beclomethasone metered-dose inhaler. Pharmacotherapy. 2003;23:1538–1544
  13. Asmus MJ, Liang J, Coowanitwong I, Hochhaus G. In vitro performance characteristics of valved holding chamber and spacer devices with a fluticasone metered-dose inhaler. Pharmacotherapy. 2004;24:159–166
  14. Louca E, Leung K, Coates AL, Mitchell JP, Nagel MW. Comparison of three valved holding chambers for the delivery of fluticasone propionate-HFA to an infant face model. J Aerosol Med. 2006;19:160–167
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  19. Barry PW, O'Callaghan C. A comparative analysis of the particle size output of beclomethasone dipropionate, salmeterol xinafoate and fluticasone dipropionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer. Br J Clin Pharmacol. 1999;47:357–360
  20. Stein SW. Size distribution measurements of metered dose inhalers using Andersen Mark II cascade impactors. Int J Pharm. 1999;186:43–52
  21. Gerrity TR. Pathophysiological and disease constraints on aerosol delivery. In:  Byron PR editors. Respiratory drug delivery. Boca Raton, USA: CRC Press Inc.; 1990;p. 1–38
  22. Roller CM, Zhang GI, Troedson RG, Leach CL, LeSoeuef PN, Devadason SG. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur Respir J. 2007;29:299–306

PII: S0954-6111(09)00061-4

doi: 10.1016/j.rmed.2009.02.010

Respiratory Medicine
Volume 103, Issue 8 , Pages 1167-1173 , August 2009

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