Respiratory Medicine
Volume 103, Issue 8 , Pages 1143-1151 , August 2009

Correlates of osteoporosis in chronic obstructive pulmonary disease: An underestimated systemic component

  • Lidwien Graat-Verboom

      Affiliations

    • Department of Respiratory Medicine, University Medical Centre Maastricht, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands
    • Department of Respiratory Medicine, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • Corresponding Author InformationCorresponding author at: University Medical Centre Maastricht, Department of Respiratory Medicine, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands. Tel.: +31 433875044; fax: +31 433875051.
    • ,
  • Martijn A. Spruit

      Affiliations

    • Research, Development and Education, Centre for Integrated Rehabilitation of Organ failure (CIRO), Hornerheide 1, 6085 NM Horn, The Netherlands
    • ,
  • Ben E.E.M. van den Borne

      Affiliations

    • Department of Respiratory Medicine, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • Frank W.J.M. Smeenk

      Affiliations

    • Department of Respiratory Medicine, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • Elisabeth J. Martens

      Affiliations

    • Department of Research and Education, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • Centre of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, Warandelaan 2, 5037 AB Tilburg, The Netherlands
    • ,
  • Ragnar Lunde

      Affiliations

    • Research, Development and Education, Centre for Integrated Rehabilitation of Organ failure (CIRO), Hornerheide 1, 6085 NM Horn, The Netherlands
    • Department of Respiratory Medicine, St Jans Gasthuis, Vogelsbeek 5, 6001 BE Weert, The Netherlands
    • ,
  • Emiel F.M. Wouters

      Affiliations

    • Department of Respiratory Medicine, University Medical Centre Maastricht, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands
    • Research, Development and Education, Centre for Integrated Rehabilitation of Organ failure (CIRO), Hornerheide 1, 6085 NM Horn, The Netherlands
    • ,
  • On behalf of the CIRO Network

      Affiliations

    • The CIRO network consists of:
      •Centre for Integrated Rehabilitation of Organ failure (CIRO), Horn, The Netherlands.

      •University Hospital Maastricht, Maastricht, The Netherlands.

      •St. Jans Gasthuis, Weert, The Netherlands.

      •Máxima Medisch Centrum, Veldhoven, The Netherlands.

      •St. Anna Hospital, Geldrop, The Netherlands.

      •Laurentius Hospital, Roermond, The Netherlands.

Received 2 December 2008 ,Accepted 22 February 2009.

References 

  1. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532–555
  2. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet. 1997;349:1436–1442
  3. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367:1747–1757
  4. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society. Am J Respir Crit Care Med. 1995;152:S77–S121
  5. Agusti AG. Systemic effects of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2:367–370
  6. Andreassen H, Vestbo J. Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective. Eur Respir J Suppl. 2003;46:2s–4s
  7. Wouters EF. Introduction: systemic effects in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2003;46:1s
  8. Schols AM, Broekhuizen R, Weling-Scheepers CA, Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr. 2005;82:53–59
  9. Vestbo J, Prescott E, Almdal T, et al. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med. 2006;173:79–83
  10. Sabit R, Bolton CE, Edwards PH, et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175:1259–1265
  11. Graat-Verboom L, Wouters EF, Smeenk FW, Borne van den BE, Lunde R, Spruit MA. Current status of research on osteoporosis in COPD: a systematic review. Eur Respir J, in press.
  12. Shepherd AJ, Cass AR, Carlson CA, Ray L. Development and internal validation of the male osteoporosis risk estimation score. Ann Fam Med. 2007;5:540–546
  13. WHO Scientific Group on the Prevention and Management of Osteoporosis . Prevention and management of osteoporosis: report of a WHO scientific group. [WHO technical report series; 921] http://whqlibdoc who int/trs/WHO_TRS_921 pdf2007;
  14. Bolton CE, Ionescu AA, Shiels KM, et al. Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170:1286–1293
  15. Engelen MP, Schols AM, Heidendal GA, Wouters EF. Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease. Am J Clin Nutr. 1998;68:1298–1303
  16. Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int. 2007;18:1197–1202
  17. Freedman BA, Potter BK, Nesti LJ, Cho T, Kuklo TR. Missed opportunities in patients with osteoporosis and distal radius fractures. Clin Orthop Relat Res. 2007;454:202–206
  18. Gruntmanis U. Male osteoporosis: deadly, but ignored. Am J Med Sci. 2007;333:85–92
  19. Hajcsar EE, Hawker G, Bogoch ER. Investigation and treatment of osteoporosis in patients with fragility fractures. CMAJ. 2000;163:819–822
  20. Wright RM. Use of osteoporosis medications in older nursing facility residents. J Am Med Dir Assoc. 2007;8:453–457
  21. Dubois EF, Roder E, Dekhuijzen PN, Zwinderman AE, Schweitzer DH. Dual energy X-ray absorptiometry outcomes in male COPD patients after treatment with different glucocorticoid regimens. Chest. 2002;121:1456–1463
  22. Gluck O, Colice G. Recognizing and treating glucocorticoid-induced osteoporosis in patients with pulmonary diseases. Chest. 2004;125:1859–1876
  23. Goldstein MF, Fallon JJ, Harning R. Chronic glucocorticoid therapy-induced osteoporosis in patients with obstructive lung disease. Chest. 1999;116:1733–1749
  24. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med. 2000;343:1902–1909
  25. Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, LaHive K, LeBoff MS. Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med. 2001;345:941–947
  26. Wong CA, Walsh LJ, Smith CJ, et al. Inhaled corticosteroid use and bone-mineral density in patients with asthma. Lancet. 2000;355:1399–1403
  27. de Vries F, van Staa TP, Bracke MS, Cooper C, Leufkens HG, Lammers JW. Severity of obstructive airway disease and risk of osteoporotic fracture. Eur Respir J. 2005;25:879–884
  28. Elmstahl S, Ekstrom H, Galvard H, Johnell O, Gerhardsson DV, Norjavaara E. Is there an association between inhaled corticosteroids and bone density in postmenopausal women?. J Allergy Clin Immunol. 2003;111:91–96
  29. Li JT, Ford LB, Chervinsky P, et al. Fluticasone propionate powder and lack of clinically significant effects on hypothalamic-pituitary-adrenal axis and bone mineral density over 2 years in adults with mild asthma. J Allergy Clin Immunol. 1999;103:1062–1068
  30. Pauwels RA, Lofdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med. 1999;340:1948–1953
  31. Incalzi RA, Caradonna P, Ranieri P, et al. Correlates of osteoporosis in chronic obstructive pulmonary disease. Respir Med. 2000;94:1079–1084
  32. Looker AC, Flegal KM, Melton LJ. Impact of increased overweight on the projected prevalence of osteoporosis in older women. Osteoporos Int. 2007;18:307–313
  33. Bonnet N, Gadois C, McCloskey E, et al. Protective effect of â blockers in postmenopausal women: influence on fracures, bone density, micro and macroarchitecture. Bone. 2007;40:1209–1216
  34. Pasco JA, Henry MJ, Sanders KM, Kotowicz MA, Seeman E, Nicholson GC. Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res. 2004;19:19–24
  35. Schoofs MW, van der Klift M, Hofman A, et al. Thiazide diuretics and the risk for hip fracture. Ann Intern Med. 2003;139:476–482
  36. Schoofs MW, Sturkenboom MC, van der KM, Hofman A, Pols HA, Stricker BH. HMG-CoA reductase inhibitors and the risk of vertebral fracture. J Bone Miner Res. 2004;19:1525–1530
  37. Haney EM, Chan BK, Diem SJ, et al. Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Intern Med. 2007;167:1246–1251
  38. Koh JM, Khang YH, Jung CH, et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005;16:1263–1271
  39. Spruit MA, Vanderhoven-Augustin I, Janssen PP, Wouters EF. Integration of pulmonary rehabilitation in COPD. Lancet. 2008;371:12–13
  40. Baarends EM, Schols AM, Mostert R, Wouters EF. Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease. Eur Respir J. 1997;10:2807–2813
  41. Boyanov M. Estimation of lumbar spine bone mineral density by dual-energy X-ray absorptiometry: standard anteroposterior scans vs sub-regional analyses of whole-body scans. Br J Radiol. 2008;81:637–642
  42. Pitta F, Troosters T, Spruit MA, Probst VS, Decramer M, Gosselink R. Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;171:972–977
  43. Dimai HP, Domej W, Leb G, Lau KH. Bone loss in patients with untreated chronic obstructive pulmonary disease is mediated by an increase in bone resorption associated with hypercapnia. J Bone Miner Res. 2001;16:2132–2141
  44. Iqbal F, Michaelson J, Thaler L, Rubin J, Roman J, Nanes MS. Declining bone mass in men with chronic pulmonary disease: contribution of glucocorticoid treatment, body mass index, and gonadal function. Chest. 1999;116:1616–1624
  45. Sin DD, Man JP, Man SF. The risk of osteoporosis in Caucasian men and women with obstructive airways disease. Am J Med. 2003;114:10–14
  46. Vik SA, Jantzi M, Poss J, et al. Factors associated with pharmacologic treatment of osteoporosis in an older home care population. J Gerontol A Biol Sci Med Sci. 2007;62:872–878
  47. Pazianas M, Miller P, Blumentals WA, Bernal M, Kothawala P. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin Ther. 2007;29:1548–1558
  48. Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity?. Bone. 2007;41:318–320
  49. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19:385–397
  50. Engelen MP, Schols AM, Lamers RJ, Wouters EF. Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease. Clin Nutr. 1999;18:275–280
  51. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–1808
  52. Reid IR. Obesity and osteoporosis. Ann Endocrinol (Paris). 2006;67:125–129
  53. Nici L, Donner C, Wouters E, et al. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006;173:1390–1413

PII: S0954-6111(09)00068-7

doi: 10.1016/j.rmed.2009.02.014

Respiratory Medicine
Volume 103, Issue 8 , Pages 1143-1151 , August 2009

Article Tools