Respiratory Medicine
Volume 103, Issue 8 , Pages 1130-1135 , August 2009

Increased apoptosis of neutrophils in induced sputum of COPD patients

  • Demosthenes Makris

      Affiliations

    • Department of Thoracic Medicine, University of Crete, Medical School, Heraklion, Crete, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 2810 392433/2410 681267.
    • ,
  • Thomas Vrekoussis

      Affiliations

    • Laboratory of Pathology, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Mbouloukaki Izoldi

      Affiliations

    • Department of Thoracic Medicine, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Kalogeraki Alexandra

      Affiliations

    • Laboratory of Pathology, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Darivianaki Katerina

      Affiliations

    • Laboratory of Pathology, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Tamiolakis Dimitris

      Affiliations

    • Laboratory of Pathology, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Alexandrakis Michalis

      Affiliations

    • Department of Hematology, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Eleni Tzortzaki

      Affiliations

    • Department of Thoracic Medicine, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Nikos M. Siafakas

      Affiliations

    • Department of Thoracic Medicine, University of Crete, Medical School, Heraklion, Crete, Greece
    • ,
  • Nikos Tzanakis

      Affiliations

    • Department of Thoracic Medicine, University of Crete, Medical School, Heraklion, Crete, Greece
    • Department of Epidemiology, Social Medicine, Medical School, University of Crete, Heraklion, Crete, Greece

Received 9 July 2008 ,Accepted 2 March 2009.

References 

  1. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;364:709–721
  2. Tumkaya M, Atis S, Ozge C, Delialioglu N, Polat G, Kanik A. Relationship between airway colonization, inflammation and exacerbation frequency in COPD. Respir Med. 2007;101(4):729–737
  3. Makris D, Lazarou S, Alexandrakis M, Kourelis TV, Tzanakis N, Kyriakou D, et al. Tc2 response at the onset of COPD exacerbations. Chest. 2008;[Epub ahead of print]
  4. Kim S, Nadel JA. Role of neutrophils in mucus hypersecretion in COPD and implications for therapy. Treat Respir Med. 2004;3:147–159
  5. O'Donnell RA, Peebles C, Ward JA, et al. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax. 2004;59:837–842
  6. Noguera A, Sala E, Pons AR, Iglesias J, MacNee W, Agusti AG. Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD. Chest. 2004;125(5):1837–1842
  7. Rytila P, Plataki M, Bucchieri F, et al. Airway neutrophilia in COPD is not associated with increased neutrophil survival. Eur Respir J. 2006;28(6):1163–1169
  8. Celli BR, MacNee W, ATS/ERS Task Force . Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004;23(6):932–946
  9. American Thoracic Society (ATS) . Standardization of spirometry, 1994 update. American Thoracic Society Am J Respir Crit Care Med. 1995;152:1107–1136
  10. Makris D, Paraskakis E, Korakas P, Karagiannakis E, Sourvinos G, Siafakas NM, et al. Exhaled breath condensate 8-isoprostane, clinical parameters, radiological indices and airway inflammation in COPD. Respiration. 2008;75(2):138–144
  11. Vandivier WR, Fadok VA, Hoffmann PR, et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002;109(5):661–670
  12. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493–501
  13. Segura-Valdez L, Pardo A, Gaxiola M, et al. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest. 2000;117:684–694
  14. Vernooy JH, Kucukaycan M, Jacobs JA, et al. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med. 2002;166(9):1218–1224
  15. Murray J, Barbara JA, Lopez AF, et al. Regulation of neutrophil apoptosis by tumour necrosis factor a requirement for CD120a (TNFR-55) and CD120b (TNFR-75) for induction of apoptosis in vitro. Blood. 1997;90:2772–2783
  16. Usher LR, Lawson RA, Geary I, et al. Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol. 2002;168(4):1861–1868
  17. Duncan CJ, Lawrie A, Blaylock MG, et al. Reduced eosinophil apoptosis in induced sputum correlates with asthma severity. Eur Respir J. 2003;22(3):484–490
  18. Matute-Bello G, Liles WC, Radella F, et al. Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997;156:1969–1977
  19. Finkelstein EI, Ruben J, Koot CW, et al. Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?. Am J Physiol Lung Cell Mol Physiol. 2005;289(6):L1019–L1028
  20. Powell WC, Fingleton B, Wilson CL, et al. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol. 1999;9:1441–1447
  21. Tuder RM, Zhen L, Cho CY, et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol. 2003;29:88–97
  22. Tan S, Wood M, Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem. 1998;71(1):95–105
  23. Golan-Gerstl R, Wallach-Dayan SB, Amir G, Breuer R. Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis. Am J Respir Cell Mol Biol. 2007;36(3):270–275
  24. McPhillips K, Janssen WJ, Ghosh M. TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms. J Immunol. 2007 Jun 15;178(12):8117–8126
  25. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483–495
  26. Perttunen H, Moilanen E, Zhang X, et al. β2-Agonists potentiate corticosteroid-induced neutrophil survival. COPD. 2008;5:163–169
  27. Zhang X, Moilanen E, Kankaanranta H. Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis. Eur J Pharmacol. 2001;431(3):365–371
  28. Zhang X, Moilanen E, Adcock IM, et al. Divergent effect of mometasone on human eosinophil and neutrophil apoptosis. Life Sci. 2002;71:1523–1534

PII: S0954-6111(09)00071-7

doi: 10.1016/j.rmed.2009.03.002

Respiratory Medicine
Volume 103, Issue 8 , Pages 1130-1135 , August 2009

Article Tools

* Image Usage & Resolution