Respiratory Medicine
Volume 103, Issue 9 , Pages 1313-1319 , September 2009

Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial

  • C. Pedroletti

      Affiliations

    • Department of Women and Child Health, Karolinska Institutet, Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 73 625 1930; fax: +46 8 5177 773.
  • ,
  • E. Millinger

      Affiliations

    • Department of Allergology, Linköping University Hospital, Sweden
  • ,
  • B. Dahlén

      Affiliations

    • Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
  • ,
  • P. Söderman

      Affiliations

    • Children's Hospital, Karolinska University Hospital Huddinge, Stockholm, Sweden
  • ,
  • O. Zetterström

      Affiliations

    • Department of Allergology, Linköping University Hospital, Sweden

Received 18 September 2008 ,Accepted 25 March 2009.

References 

  1. Custovic A, Simpson A, Chapman MD, Woodcock A. Allergen avoidance in the treatment of asthma and atopic disorders. Thorax. 1998;53:63–72
  2. Platts-Mills TA, Vaughan JW, Carter MC, Woodfolk JA. The role of intervention in established allergy: avoidance of indoor allergens in the treatment of chronic allergic disease. J Allergy Clin Immunol. 2000;106(5):787–804
  3. Piacentini GL, Bodini A, Costella S, Vicentini L, Peroni D, Zanolla L, et al. Allergen avoidance is associated with a fall in exhaled nitric oxide in asthmatic children. J Allergy Clin Immunol. 1999;104(6):1323–1324
  4. Peroni DG, Piacentini GL, Costella S, Pietrobelli A, Bodini A, Loiacono A, et al. Mite avoidance can reduce air trapping and airway inflammation in allergic asthmatic children. Clin Exp Allergy. 2002;32(6):850–855
  5. Clearing the air: asthma and indoor air exposure. US: Institute of Medicine; 2000. p. 367–78 (ISBN 0-309-06496-1).
  6. Almqvist C, Larsson PH, Egmar AC, Hedren M, Malmberg P, Wickman M. School as a risk environment for children allergic to cats and a site for transfer of cat allergen to homes. J Allergy Clin Immunol. 1999;103(6):1002–1004
  7. Andersson I-M, Rosén G, Kristensson J. Evaluation of a ceiling-mounted low-impulse air inlet for control of air pollution. Sweden: National Institute of Health; 1995;
  8. Technical trial results in home environments with Airsonett Airshower, 2001, Airsonett AB. Data on file Airsonett AB.
  9. Juniper EF, Guyatt GH, Cox FM, Ferrie PJ, King DR. Development and validation of the Mini Asthma Quality of Life Questionnaire. Eur Respir J. 1999;14:32–38
  10. Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol. 1994;47(1):81–87
  11. Juniper EF, Jenkins C, Price MJ, James MH. Impact of inhaled salmeterol/fluticasone propionate combination product versus budesonide on the Health-Related Quality of Life of Patients with Asthma. Am J Respir Med. 2002;1(6):435–440
  12. American Thoracic Society Documents ATS/ERS. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide; 2005.
  13. American Thoracic Society . Standardization of spirometry, 1994 update. Am J Respir Crit Care Med. 1995;152:1107–1136
  14. Lunell E. Pilot Study of the effects of 4weeks’ night-time use of the Airsonett Airshower® on the quality of life (mini-AQLQ) of patients with asthma; 2001 (data on file, Airsonett AB).
  15. Verrall B, Muir DC, Wilson WM, Milner R, Johnston M, Dolovich J. Laminar flow air cleaner bed attachment: a controlled trial. Ann Allergy. 1988 Aug;61(2):117–122
  16. Zwemer RJ, Karibo J. Use of laminar control device as adjunct to standard environmental control measures in symptomatic asthmatic children. Ann Allergy. 1973;31(6):284–290
  17. Bräuner EV, et al. Indoor particles affect vascular function in the aged. An air filtration-based study. Am J Respir Crit Care Med. 2008;177:319–325
  18. Mills NL. Reducing exposure to airborne particles. A novel strategy to improve cardiovascular health. Editorial. Am J Respir Crit Care Med. 2008;177:366–367
  19. Månsson L. Cleanroom technology. Nordic Jf Contamination Control and Cleanroom Technol 4; 2003: 7–13.
  20. Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Dose–response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest. 2001;119(5):1322–1328
  21. Payne DN. Nitric oxide in allergic airway inflammation. Curr Opin Allergy Clin Immunol. 2003;3(2):133–137
  22. Grootendorst DC, Dahlén S-E, Van den Bos JW, Duiverman EJ, Veselic-Charvat M, Vrijlandt EJLE, et al. Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids. Clin Exp Allergy. 2001;31:400–408
  23. Bates CA, Silkoff PE. Exhaled nitric oxide in asthma: from bench to bedside. J Allergy Clin Immunol. 2003 Feb;111(2):256–262

PII: S0954-6111(09)00101-2

doi: 10.1016/j.rmed.2009.03.020

Respiratory Medicine
Volume 103, Issue 9 , Pages 1313-1319 , September 2009