Respiratory Medicine
Volume 103, Issue 12 , Pages 1832-1837 , December 2009

Peak inspiratory flow through the Genuair® inhaler in patients with moderate or severe COPD

  • H. Magnussen

      Affiliations

    • Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 4102601151; fax: +49 4102601245.
    • ,
  • H. Watz

      Affiliations

    • Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    • ,
  • I. Zimmermann

      Affiliations

    • Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    • ,
  • S. Macht

      Affiliations

    • Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany
    • ,
  • R. Greguletz

      Affiliations

    • Almirall Sofotec GmbH, Benzstrasse 1, D-61352 Bad Homburg v. d. Hoehe, Germany
    • ,
  • M. Falques

      Affiliations

    • Almirall, R&D Centre, Laureà Miró 408-410, 08980 Sant Feliu de Llobregat, Barcelona, Spain
    • ,
  • D. Jarreta

      Affiliations

    • Almirall, R&D Centre, Laureà Miró 408-410, 08980 Sant Feliu de Llobregat, Barcelona, Spain
    • ,
  • E. Garcia Gil

      Affiliations

    • Almirall, R&D Centre, Laureà Miró 408-410, 08980 Sant Feliu de Llobregat, Barcelona, Spain

Received 13 February 2009 ,Accepted 13 July 2009.

References 

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  2. Feddah MR, Brown KF, Gipps EM, Davies NM. In-vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates. J Pharm Pharm Sci. 2000;3:318–324
  3. Smith K, Chan H, Brown K. Influence of flow rate on aerosol particle size distributions from pressurized and breath-actuated inhalers. J Aerosol Med. 1998;11:231–245
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  5. Janssens W, VandenBrande P, Hardeman E, et al. Inspiratory flow rates at different levels of resistance in elderly COPD patients. Eur Respir J. 2008;31:78–83
  6. Global Strategy for the Diagnosis . Management and prevention of COPD, global initiative for chronic obstructive lung disease [GOLD]. Available from: http://www.goldcopd.com2007;
  7. de Koning JP, van der Mark ThW, Coenegracht PMJ, Tromp ThFJ, Frijlink HW. Effect of an external resistance to airflow on the inspiratory flow curve. Int J Pharm. 2002;234:257–266
  8. Buist AS, Vollmer WM, McBurnie MA. Worldwide burden of COPD in high- and low-income countries. Part 1. The burden of obstructive lung disease (BOLD) initiative. J Tuberc Lung Dis. 2008;12:703–708
  9. Halbert RJ, Natoli JL, Gano A. Global burden of COPD: systematic review and meta-analysis. Eur Respir J. 2006;28:523–532
  10. Srichana T, Martin GP, Marriott C. Dry powder inhalers: the influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur J Pharm Sci. 1998;7:73–80
  11. Chodosh S, Flanders JS, Kesten S, Serby CW, Hochrainer D, Witek TJ. Effective delivery of particles with the handihaler dry powder inhalation system over a range of chronic obstructive pulmonary disease severity. J Aerosol Med. 2001;14:309–315
  12. Newman S, Sutton D, Segarra R, Lamarca R, de Miquel G. Lung deposition of aclidinium bromide from genuair, a multidose dry powder inhaler. Respiration. 2009;Epub ahead of print
  13. Brand P, Meyer T, Weuthen T. Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease. J Clin Pharmacol. 2007;47:1335–1341

PII: S0954-6111(09)00239-X

doi: 10.1016/j.rmed.2009.07.006

Respiratory Medicine
Volume 103, Issue 12 , Pages 1832-1837 , December 2009

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