Respiratory Medicine
Volume 103, Issue 12 , Pages 1801-1806 , December 2009

Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension

  • Jianqiang Zhang

      Affiliations

    • Research Center for Pathology and Physiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi Cheng District, Beijing 100037, China
  • ,
  • Ying Zhang

      Affiliations

    • Research Center for Pathology and Physiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi Cheng District, Beijing 100037, China
  • ,
  • Ning Li

      Affiliations

    • Research Center for Pathology and Physiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi Cheng District, Beijing 100037, China
  • ,
  • Zhihong Liu

      Affiliations

    • Pulmonary Vascular Diseases Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • ,
  • Changming Xiong

      Affiliations

    • Pulmonary Vascular Diseases Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • ,
  • Xinhai Ni

      Affiliations

    • Pulmonary Vascular Diseases Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • ,
  • Yaoli Pu

      Affiliations

    • Duke University, Durham, NC, USA
  • ,
  • Rutai Hui

      Affiliations

    • Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • ,
  • Jianguo He

      Affiliations

    • Pulmonary Vascular Diseases Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    • Corresponding Author InformationCorresponding author.
  • ,
  • Jielin Pu

      Affiliations

    • Research Center for Pathology and Physiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei-Li-Shi Road, Xi Cheng District, Beijing 100037, China
    • Corresponding Author InformationCorresponding author. Tel./fax: +86 10 88398531.

Received 20 April 2009 ,Accepted 26 July 2009.

References 

  1. Rich S, Danzker DR, Ayres SM, et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med. 1987;107:216–223[PubMed: 3605900]
  2. Nagaya N, Uematsu M, Satoh T, et al. Serum uric acid levels correlate with the severity and the mortality of primary pulmonary hypertension. Am J Respir Crit Care Med. 1999;160:487–492[PubMed: 10430718]
  3. Torbicki A, Kurzyna M, Kuca P, et al. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension. Circulation. 2003;108:844–848[PubMed: 12900346]
  4. Rubens C, Ewert R, Halank M, et al. Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. Chest. 2001;120:1562–1569[PubMed: 11713135]
  5. Nagaya N, Nishikimi T, Uematsu M, et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation. 2000;102:865–870[PubMed: 10952954]
  6. Yi ES, Kim H, Ahn H, et al. Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study. Am J Respir Crit Care Med. 2000;162:1577–1586[PubMed:11029379]
  7. Cool CD, Stewart JS, Werahera P, et al. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth. Am J Pathol. 1999;155:411–419[PubMed:10433934]
  8. Machado RD, Pauciulo MW, Thomson JR, et al. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet. 2001;68:92–102[PubMed: 11115378]
  9. Lane KB, Machado RD, Pauciulo MW, et al. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet. 2000;26:81–84[PubMed: 10973254]
  10. Sun D, Kar S, Carr BI. Differentially expressed genes in TGF-β1 sensitive and resistant human hepatoma cells. Cancer Lett. 1995;89:73–79[PubMed: 7882305]
  11. Reimann T, Hempel U, Krautwald S, et al. Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett. 1997 Feb 10;403(1):57–60[PubMed: 9038360]
  12. Bezstarosti K, Das S, Lamers JM, Das DK. Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol. J Cell Mol Med. 2006;10(4):896–907[PubMed: 17125593]
  13. Gallego-Delgado J, Lazaro A, Osende JI, et al. Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies. J Am Soc Nephrol. 2006;17(12 Suppl. 3):S159–S164[PubMed: 17130255]
  14. Atkinson C, Stewart S, Upton PD, et al. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation. 2002;105(14):1672–1678[PubMed: 11940546]
  15. Botney MD, Bahadori L, Gold LI. Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta. Am J Pathol. 1994;144(2):286–295[PubMed: 8311113]
  16. Richter A, Yeager ME, Zaiman A, et al. Impaired transforming growth Factor β signaling in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2004;170(12):1340–1348[PubMed: 15361368]
  17. Gray MO, Long CS, Kalinyak JE, et al. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. Cardiovasc Res. 1998;40:352–363[PubMed: 9893729]
  18. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007;74:184–195[PubMed: 17109837]
  19. Matsumoto-Ida M, Takimoto Y, Aoyama T, et al. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol. 2006;290(2):H709–H715[PubMed: 16183734]
  20. Li G, Borger MA, Williams WG, et al. Regional overexpression of insulin-like growth factor-I and transforming growth factor-beta1 in the myocardium of patients with hypertrophic obstructive cardiomyopathy. J Thorac Cardiovasc Surg. 2002;123:89–95[PubMed: 11782760]
  21. Holweg CT, Baan CC, Niesters HG, et al. TGF-beta1 gene polymorphisms in patients with end-stage heart failure. J Heart Lung Transplant. 2001;20:979–984[PubMed: 11557193]
  22. Buono C, Come CE, Witztum JL, et al. Influence of C3 deficiency on atherosclerosis. Circulation. 2002 Jun 25;105(25):3025–3031[PubMed: 12081998]
  23. Barrington R, Zhang M, Fischer M, Carroll MC. The role of complement in inflammation and adaptive immunity. Immunol Rev. 2001;180:5–15[PubMed: 11414363]
  24. Toapanta FR, Ross TM. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Immunol Res. 2006;36(13):197–210[PubMed: 17337780]
  25. Peerschke EI, Minta JO, Zhou SZ, et al. Expression of gC1q-R/p33 and its major ligands in human atherosclerotic lesions. Mol Immunol. Jul 2004;41(8):759–766[PubMed: 15234555]
  26. Moser KM, Fedullo PF, Finkbeiner WE, et al. Do patients with primary pulmonary hypertension develop extensive central thrombi?. Circulation. 1995;91:741–745[PubMed: 7828302]
  27. Marshall MS. Ras target proteins in eukaryotic cells. FASEB J. 1995;9(13):1311–1318[PubMed: 7557021]
  28. Marais R, Marshall CJ. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 1996;27:101–125[PubMed: 8909797]

 This work was funded by National Basic Research Program of China (973 program projects, program number: 2007CB512000, and project number: 2007CB512008 to J. Pu).

PII: S0954-6111(09)00249-2

doi: 10.1016/j.rmed.2009.07.017

Respiratory Medicine
Volume 103, Issue 12 , Pages 1801-1806 , December 2009