Effects of corticosteroid use on readmission in obstructive lung disease

Velthove, Karin J.; Souverein, Patrick C.; van Solinge, Wouter W.; Leufkens, Hubert G.M.; Lammers, Jan-Willem J.

doi:10.1016/j.rmed.2009.08.014

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Volume 104, Issue 2 , Pages 211-218, February 2010

Effects of corticosteroid use on readmission in obstructive lung disease

Karin J. Velthove
- Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
- Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
Patrick C. Souverein
- Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
Wouter W. van Solinge
- Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
- Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
Hubert G.M. Leufkens
- Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
Jan-Willem J. Lammers
- Department of Respiratory Medicine, Division of Heart and Lungs, University Medical Center Utrecht, Internal Post No. E 03.511, PO Box 85500, 3508 GA Utrecht, The Netherlands
- Corresponding author. Tel.: +31 88 755 6180; fax: +31 88 755 5415.

Received 2 June 2009; accepted 28 August 2009. published online 25 September 2009.

Summary

Objective

Obstructive lung disease is a leading cause of morbidity and mortality worldwide. Some patients are readmitted, but currently predicting parameters for identifying these patients are lacking. The aim of this study was to quantify the incidence of readmission in chronic obstructive lung disease and to identify determinants for hospital readmission.

Methods

We conducted a cohort study using the PHARMO record linkage system, including demographic details and complete medication histories of more than two million community-dwelling residents in the Netherlands from 1985 onwards. Eligible patients were adult users of inhaled corticosteroids (ICS) with an admission for obstructive lung disease. The outcome parameter was readmission within a follow-up period of one year.

Results

We identified 605 ICS users with an admission for chronic obstructive lung disease, 132 of these patients were readmitted. Readmission was associated with a high Chronic Disease Score (adjusted HR 2.4; 95% CI 1.1–5.3). Patients using short courses of systemic corticosteroids only (adjusted HR 0.5; 95% CI 0.4–0.8) or combined with antibiotics (adjusted HR 0.4; 95% CI 0.2–0.6) were at decreased risk of readmission. The effect of high-dose ICS use varied over time.

Conclusions

Treatment of exacerbations out of the hospital was associated with a decreased risk of readmission, while patients with multiple chronic diseases are at increased risk of readmission for obstructive lung disease. These patients should be educated and should be invited to consultation more often to be able to detect exacerbation in an early phase and start treatment as early as possible.

Keywords: Corticosteroid, Exacerbation, ICS, Obstructive lung disease, Readmission