Respiratory Medicine
Volume 104, Issue 2 , Pages 260-266 , February 2010

Prevalence and predictors of vertebral fracture in patients with chronic obstructive pulmonary disease

  • Sumit R. Majumdar

      Affiliations

    • Department of Medicine, University of Alberta, 2F1.24 Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112th Street, Edmonton, Alberta, Canada, T6G 2B7
    • Corresponding Author InformationCorresponding author. Tel.: +1 780 407 1399; fax: +1 780 407 3132.
    • ,
  • Cristina Villa-Roel

      Affiliations

    • Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Kristin J. Lyons

      Affiliations

    • Department of Medicine, University of Alberta, 2F1.24 Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112th Street, Edmonton, Alberta, Canada, T6G 2B7
    • ,
  • Brian H. Rowe

      Affiliations

    • Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada

Received 29 April 2009 ,Accepted 22 September 2009.

References 

  1. Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest. 2002;121(suppl):121S–126S
  2. Reginster J, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2005;38(suppl):S4–S9
  3. O'Donnel DE, Aaron S, Bourbeau J, Hernandex P, Marchiniuk DD, et al. Canadian thoracic society recommendations for management of chronic obstructive pulmonary disease-2007 update. Can Respir J. 2007;14(Suppl. B):5B–32B
  4. Jorgensen NR, Schwarz P. Osteoporosis in chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2008;14:84–92
  5. Gross NJ. Extrapulmonary effects of chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2001;7:122–127
  6. Scientific Advisory Council . Osteoporosis society of Canada. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ. 2002;167(suppl):S1–S34
  7. Gan WZ, Man SFP, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59:574–580
  8. Gluck O, Colic G. Recognizing and treating glucocorticoid induced osteoporosis in patients with pulmonary disease. Chest. 2004;125:1859–1876
  9. Antonelli Incalzi R, Caradonna P, Ranieri P, Basso S, Fuso L, et al. Correlates of osteoporosis in chronic obstructive pulmonary disease. Resp Med. 2000;94:1079–1084
  10. Papaioannou A, Watts NB, Kendler DL, Yuen CK, Adachi JD, Ferko N. Diagnosis and management of vertebral fractures in elderly adults. Am J Med. 2002;113:220–228
  11. Harrison RA, Siminoski K, Vethanayagam D, Majumdar SR. Osteoporosis-related kyphosis and impairments in pulmonary function: A systematic review. J Bone Miner Res. 2007;22:247–457
  12. Cooper C, Melton LJ. Vertebral fractures: how large is the silent epidemic?. BMJ. 1992;304:793–794
  13. Papaionnou A, Parkinson W, Ferko N, Probyn L, Ioannidis G, et al. Prevalence of vertebral fractures among patients with chronic obstructive pulmonary disease in Canada. Osteoporos Int. 2003;14:913–917
  14. MacLean C, Newberry S, Maglione M, MmMhon M, Ranganath V, et al. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008;148:197–213
  15. Kim N, Rowe BH, Raymond G, Jen H, Colman I, et al. Under-reporting of vertebral fractures on routine chest radiography. AJR Am J Roentgenol. 2004;182:297–300
  16. Majumdar SR, Kim N, Colman I, Chahal AM, Raymond G, et al. Incidental vertebral fractures discovered with chest radiography in the emergency department. Arch Intern Med. 2005;165:905–909
  17. Carter JD, Patel S, Sultan FL, Thompson ZJ, Margaux H, et al. The recognition and treatment of vertebral fractures in males with chronic obstructive pulmonary disease. Respir Med. 2008;102:1165–1172
  18. McEvoy CE, Ensrud KE, Bender E, Genant HK, Yu W. Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:704–709
  19. Jorgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ. The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease-a cross sectional study. Resp Med. 2007;101:177–185
  20. Angeli A, Guglielmi G, Dovoi A, Capelli G, de Fe D, et al. High prevalence of asymptomatic vertebral fractures in post menopausal women receiving chronic glucocorticoid therapy:a cross sectional study. Bone. 2006;39:253–259
  21. Nuti R, Siviero P, Maggi S, Guglielmi G, Cafarelli C, Crepaldi G, et al. Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study. Osteoporos Int. 2009;20:989–998
  22. Anthonisen N, Manfreda J, Warren P, Hershfield E, Harding G, Nelson N. Antibiotic therapy in exacerbation of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106:196–204
  23. Genant HK, Wu CY, Van Kuijk C. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993;8:1137–1148
  24. Roy DK, O'Neill TW, Finn JD, Lunt M, Silman AJ, et al. Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int. 2003;14:19–26
  25. Papaioannou A, Kennedy CC, Cranney A, Hawker G, Brown JP, Kaiser SM, et al. Risk factors for low BMD in healthy men age 50 years or older: a systematic review. Osteoporos Int. 2009;20:507–518
  26. Morin S, Tsang JF, Leslie WD. Weight and body mass index predict bone mineral density and fractures in women aged 40–59 years. Osteoporos Int. 2009;20:363–370
  27. Iqbal F, Michaelson J, Thaler L, Rubin J, Roman J, et al. Declining bone mass in men with chronic pulmonary disease; contribution of glucocorticoid treatment, body mass index and gonadal function. Chest. 1999;116:1616–1624
  28. Agusti A, Sorian JB. COPD as a systemic disease. COPD. 2008;5:133–138
  29. Bolton CE, Ionescu AA, Shiels KM, Pettit RJ, Edwards PH. Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170:1286–1293
  30. Sin DD, Man JP, Man SFP. The risk of osteoporosis in Caucasian men and women with obstructive airways disease. Am J Med. 2003;114:10–14
  31. Vrieze A, de Greef MHG, Wykstra PJ. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat free mass. Osteoporos Int. 2007;18:1197–1202
  32. Kjensli A, Mowinchel P, Ryg RS, Falch JA. Low bone mineral density is related to severity of chronic obstructive pulmonary disease. Bone. 2007;40:493–497
  33. de Vries F, van Staa TP, Bracke MSGM, Cooper C, Leufkens HGM, et al. Severity of obstructive airway disease and risk of osteoporotic fracture. Eur Respir J. 2005;25:879–884
  34. Melton LJ, Thamer M, Ray NF, Chan JK, Chesnut CH, et al. Fractures attributable to osteoporosis: report from the national osteoporosis foundation. J Bone Miner Res. 1997;12:16–23
  35. Majumdar SR, Johnson JA, McAlister FA, Bellerose D, Russell AS, et al. Multifaceted intervention to improve osteoporosis diagnosis and treatment in patients with recent wrist fracture: a randomized controlled trial. CMAJ. 2008;178:569–575

☆ Supported by: Peer reviewed grants from the Canadian Association of Emergency Physicians Research Consortium. SRM receives salary support from the Alberta Heritage Foundation for Medical Research (Health Scholar); BHR holds a Canada Research Chair in Emergency Airway Diseases.

PII: S0954-6111(09)00312-6

doi: 10.1016/j.rmed.2009.09.013

Respiratory Medicine
Volume 104, Issue 2 , Pages 260-266 , February 2010

Article Tools

* Image Usage & Resolution