Respiratory Medicine
Volume 104, Issue 3 , Pages 440-447 , March 2010

Genetic variability in the severity and outcome of community-acquired pneumonia

  • Jordi Solé-Violán

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 928 449 511; fax: +34 928 449293.
    • ,
  • Felipe Rodríguez de Castro

      Affiliations

    • Respiratory Disease Service, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • M. Isabel García-Laorden

      Affiliations

    • Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • José Blanquer

      Affiliations

    • Intensive Care Unit, Hospital Clínico y Universitario de Valencia, Av. Blasco Ibáñez 17, 46010 Valencia, Spain
    • ,
  • Javier Aspa

      Affiliations

    • Respiratory Disease Service, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain
    • ,
  • Luis Borderías

      Affiliations

    • Respiratory Disease Service, Hospital San Jorge, Av. Martínez Velasco 36, 22071 Huesca, Spain
    • ,
  • M. Luisa Briones

      Affiliations

    • Respiratory Disease Service, Hospital Clínico y Universitario de Valencia, Blasco Ibáñez 17, 46010 Valencia, Spain
    • ,
  • Olga Rajas

      Affiliations

    • Respiratory Disease Service, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain
    • ,
  • Ignacio Martín-Loeches Carrondo

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • Critical Care Department, Joan XXIII University Hospital, CIBER Enfermedades Respiratorias (CIBERES), 43007 Tarragona, Spain
    • ,
  • José Alberto Marcos-Ramos

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • José María Ferrer Agüero

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • Ayoze Garcia-Saavedra

      Affiliations

    • Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • M. Dolores Fiuza

      Affiliations

    • Research Unit Hospital, Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • Araceli Caballero-Hidalgo

      Affiliations

    • Research Unit Hospital, Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain
    • ,
  • Carlos Rodriguez-Gallego

      Affiliations

    • Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrín, Barranco de la Ballena S/N, 35020 Las Palmas de Gran Canaria, Spain

Received 29 July 2009 ,Accepted 13 October 2009.

References 

  1. Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27–72
  2. Wunderink RG, Waterer GW. Genetics of community-acquired pneumonia. Semin Respir Crit Care Med. 2005;25:553–562
  3. Lisboa T, Diaz E, Sa-Borges M, Socias A, Sole-Violan J, Rodríguez A, et al. The ventilator-associated pneumonia PIRO score: a tool for predicting ICU mortality and health-care resources use in ventilator-associated pneumonia. Chest. 2008;134:1208–1216
  4. Lin MT, Albertson TE. Genomic polymorphisms in sepsis. Crit Care Med. 2004;32:569–579
  5. Clark MF, Baudouin SV. A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med. 2006;32:1706–1712
  6. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644–1655
  7. Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336:243–250
  8. Bernard GR, Artigas A, Brigham KL, et al. The American European consensus conference on ARDS: definitions mechanisms, relevant outcomes and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818–824
  9. Knaus WA, Draper EA, Wagner DP, ZimmermanAPACHE JE. a severity of disease classification system. Crit Care Med. 1985;13:818–829
  10. Bestmann L, Helmy N, Garofalo F, et al. LightCycler PCR for the polymorphisms −308 and −238 in the TNF alpha gene and for the TNFB1/B2 polymorphism in the LT alpha gene. In:  Dietmaier W,  Wittwer C,  Sivasubramanian N editor. Rapid cycle real-time PCR methods and applications (genetics and oncology). New York, LLC: Springer-Verlag; 2002;p. 93–105
  11. Hurme M, Santtila S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes. Eur J Immunol. 1998;8:2598–2602
  12. Ye S, Dhillon S, Ke X, Collins AR, Day IN. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res. 2001;17:E88
  13. Bridges SL, Jenq G, Moran M, Kuffner T, Whitworth WC, McNicholl J. Single-nucleotide polymorphisms in tumor necrosis factor receptor genes: definition of novel haplotypes and racial/ethnic differences. Arthritis Rheum. 2002;46:2045–2050
  14. Dinarello CA. The use of cytokine knockouts to study host defense against infection. New Jersey In:  Fantuzzi G editors. Cytokine knockouts. Totowa: Humana Press Inc.; 2003;p. 11–31
  15. Mira JP, Cariou A, Grall F, et al. Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA. 1999;282:561–568
  16. Waterer GW, Quasney MW, Cantor RM, Wunderink RG. Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am J Respir Crit Care Med. 2001;163:1599–1604
  17. Appoloni O, Dupont E, Vandercruys M, Andriens M, Duchateau J, Vincent JL. Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock. Am J Med. 2001;110:486–488
  18. Menges T, König IR, Hossain H, et al. Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med. 2008;36:1456–1462
  19. Stuber F, Udalova IA, Book M, et al. −308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm. 1995;46:42–50
  20. Reid CL, Perrey C, Pravica V, Hutchinson IV, Campbell IT. Genetic variation in proinflammatory and anti-inflammatory cytokine production in multiple organ dysfunction syndrome. Crit Care Med. 2002;30:2216–2221
  21. Gordon AC, Lagan AL, Aganna E, et al. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun. 2004;5:631–640
  22. Jessen KM, Lindboe SB, Petersen AL, Eugen-Olsen J, Benfield T. Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis. 2007;7:108
  23. Fang XM, Schröder S, Hoeft A, Stüber F. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med. 1999;27:1330–1334
  24. Waterer GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG. Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit Care Med. 2003;31:1367–1372
  25. Gallagher PM, Lowe G, Fitzgerald T, et al. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax. 2003;58:154–156
  26. Schlüter B, Raufhake C, Erren M, et al. Effect of the interleukin-6 promoter polymorphism (−174 G/C) on the incidence and outcome of sepsis. Crit Care Med. 2002;30:32–37
  27. Balding J, Healy CM, Livingstone WJ, et al. Genomic polymorphic profiles in an Irish population with meningococcaemia: is it possible to predict severity and outcome of disease?. Genes Immun. 2003;4:533–540
  28. Sutherland AM, Walley KR, Manocha S, Russell JA. The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Intern Med. 2005;165:75–82
  29. Arnalich F, López-Maderuelo D, Codoceo R, et al. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Clin Exp Immunol. 2002;127:331–336
  30. Ma P, Chen D, Pan J, Du B. Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients. Crit Care Med. 2002;30:1046–1050
  31. Bradley JR. TNF-mediated inflammatory disease. J Pathol. 2008;214:149–160
  32. Till A, Rosenstiel P, Krippner-Heidenreich A, et al. The Met-196→Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression. J Biol Chem. 2005;280:5994–6004
  33. Horiuchi T, Kiyohara C, Tsukamoto H, et al. A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. Ann Rheum Dis. 2007;66:320–324
  34. Glossop JR, Dawes PT, Nixon NB, Mattey DL. Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. Arthritis Res Ther. 2005;7:R1227–R1234
  35. Waschke KA, Villani AC, Vermeire S, et al. Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. Am J Gastroenterol. 2005;100:1126–1133
  36. Rooryck C, Barnetche T, Richez C, Laleye A, Arveiler B, Schaeverbeke T. Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy. Clin Exp Rheumatol. 2008;26:340–342
  37. Slowik MR, De Luca LG, Fiers W, Pober JS. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am J Pathol. 1993;143:1724–1730
  38. Herman C, Chernajovsky Y. Mutation of proline 211 reduces shedding of the human p75 TNF receptor. J Immunol. 1998;160:2478–2487
  39. Till A, Rosenstiel P, Krippner-Heidenreich A, et al. The Met-196→Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-α-induced apoptosis by impaired NF-κB signalling and target gene expression. J Biol Chem. 2005;280:5994–6004
  40. Bohrer H, Qiu F, Zimmermann T, et al. Role of NF-κB in the mortality of sepsis. J Clin Invest. 1997;100:972–985
  41. Arcaroli J, Silva E, Maloney JP, et al. Variant IRAK-1 haplotype is associated with increased nuclear factor-κB activation and worse outcomes in sepsis. Am J Resp Crit Care Med. 2006;173:1335–1341
  42. Ku CL, von Bernuth H, Picard C, et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007;204:2407–2422
  43. von Bernuth H, Picard C, Jin Z, et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008;321(5889):691–696
  44. Khor CC, Chapman SJ, Vannberg FO, et al. A Ma1 functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007;39:523–528

PII: S0954-6111(09)00330-8

doi: 10.1016/j.rmed.2009.10.009

Respiratory Medicine
Volume 104, Issue 3 , Pages 440-447 , March 2010

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