Respiratory Medicine
Volume 104, Issue 3 , Pages 371-377 , March 2010

Effect of mannitol and repetitive coughing on the sputum properties in bronchiectasis

  • Evangelia Daviskas

      Affiliations

    • Department of Respiratory & Sleep Medicine, Royal Prince Alfred Hospital, 11 West, Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 2 9515 7410; fax: +61 2 9515 8196.
    • ,
  • Sandra D. Anderson

      Affiliations

    • Central Clinical School, School of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    • ,
  • Iven H. Young

      Affiliations

    • Department of Respiratory & Sleep Medicine, Royal Prince Alfred Hospital, 11 West, Missenden Road, Camperdown, Sydney, NSW 2050, Australia

Received 22 September 2009 ,Accepted 23 October 2009.

References 

  1. Currie DC, Pavia D, Agnew JE, et al. Impaired tracheobronchial clearance in bronchiectasis. Thorax. 1987;42:126–130
  2. Isawa T, Teshima T, Hirano T, et al. Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J Nucl Med. 1990;31:543–548
  3. Daviskas E, Anderson SD, Eberl S, Chan HK, Bautovich G. Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis. Am J Respir Crit Care Med. 1999;159:1843–1848
  4. Daviskas E, Anderson SD, Eberl S, Chan HK, Young IH. The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest. 2001;119:414–421
  5. Daviskas E, Anderson SD, Eberl S, Young IH. Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis. Eur Respir J. 2008;31:765–772
  6. O'Donnell AE. Bronchiectasis. Chest. 2008;134:815–823
  7. Daviskas E, Anderson SD, Gomes K, et al. Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology. 2005;10:46–56
  8. Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res. 2005;6:144
  9. Albers GM, Tomkiewicz RP, May MK, Ramirez OE, Rubin BK. Ring distraction technique for measuring surface tension of sputum: relationship to sputum clearability. J Appl Physiol. 1996;81:2690–2695
  10. Daviskas E, Anderson SD, Young IH. Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion. Respirology. 2007;12:683–691
  11. Vaquez-Girod S, Zahm JM, Dionisius JP, Pierrot D, Puchelle E. Automatic measurement of the wetting properties of biological fluids. Innov Tech Biol Med. 1988;9:402–412
  12. Button B, Boucher RC. Role of mechanical stress in regulating airway surface hydration and mucus clearance rates. Respiratory Physiology and Neurobiology. 2008;163:189–201
  13. Davis CW, Lazarowski ER. Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling. Respiratory Physiology and Neurobiology. 2008;163:208–213
  14. Zahm JM, King M, Duvivier C, Pierrot D, Girod S, Puchelle E. Role of simulated repetitive coughing in mucus clearance. Eur Respir J. 1991;4:311–315
  15. Boucher RC. Relationship of airway epithelial ion transport to chronic bronchitis. Proc Am Thorac Soc. 2004;1:66–70
  16. Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol. 2001;118:223–236
  17. Hasani A, Pavia D, Agnew JE, Clarke SW. Regional lung clearance during cough and forced expiration technique (FET): effects of flow and viscoelasticity. Thorax. 1994;49:557–561

PII: S0954-6111(09)00354-0

doi: 10.1016/j.rmed.2009.10.021

Respiratory Medicine
Volume 104, Issue 3 , Pages 371-377 , March 2010

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