Respiratory Medicine
Volume 104, Issue 4 , Pages 518-524 , April 2010

Temazepam 10mg does not affect breathing and gas exchange in patients with severe normocapnic COPD

  • Gerben Stege

      Affiliations

    • Department of Pulmonology, Rijnstate Hospital, Arnhem, The Netherlands
    • Corresponding Author InformationCorresponding author. Department of Pulmonology, Rijnstate Hospital, P.O. Box 9555, 6800 TA, Arnhem, The Netherlands. Tel.: +31 (0) 26 3786226; fax: +31 (0) 26 3786124.
    • ,
  • Yvonne F. Heijdra

      Affiliations

    • Department of Pulmonology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
    • ,
  • Frank J.J. van den Elshout

      Affiliations

    • Department of Pulmonology, Rijnstate Hospital, Arnhem, The Netherlands
    • ,
  • Marjo J.T. van de Ven

      Affiliations

    • Department of Pulmonology, Rijnstate Hospital, Arnhem, The Netherlands
    • ,
  • Peter J. de Bruijn

      Affiliations

    • Department of Pulmonology, Rijnstate Hospital, Arnhem, The Netherlands
    • ,
  • Adriaan A. van Sorge

      Affiliations

    • Department of Clinical Pharmacy & Pharmacology, Rijnstate Hospital, Arnhem, the Netherlands
    • ,
  • P.N. Richard Dekhuijzen

      Affiliations

    • Department of Pulmonology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
    • ,
  • Petra J.E. Vos

      Affiliations

    • Department of Pulmonology, Rijnstate Hospital, Arnhem, The Netherlands

Received 22 December 2008 ,Accepted 27 October 2009.

References 

  1. Klink M, Quan SF. Prevalence of reported sleep disturbances in a general adult population and their relationship to obstructive airways diseases. Chest. 1987;91:540–546
  2. Klink ME, Dodge R, Quan SF. The relation of sleep complaints to respiratory symptoms in a general population. Chest. 1994;105:151–154
  3. Kinsman RA, Yaroush RA, Fernandez E, Dirks JF, Schocket M, Fukuhara J. Symptoms and experiences in chronic bronchitis and emphysema. Chest. 1983;83:755–761
  4. Cormick W, Olson LG, Hensley MJ, Saunders NA. Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease. Thorax. 1986;41:846–854
  5. Fleetham J, West P, Mezon B, Conway W, Roth T, Kryger M. Sleep, arousals, and oxygen desaturation in chronic obstructive pulmonary disease. The effect of oxygen therapy. Am Rev Respir Dis. 1982;126:429–433
  6. Zammit GK, Weiner J, Damato N, Sillup GP, McMillan CA. Quality of life in people with insomnia. Sleep. 1999;22(Suppl. 2):S379–385
  7. Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF, Kupfer DJ. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. Jama. 1997;278:2170–2177
  8. Curry DT, Eisenstein RD, Walsh JK. Pharmacologic management of insomnia: past, present, and future. Psychiatr Clin North Am. 2006;29:871–893
  9. Erman MK. Therapeutic options in the treatment of insomnia. J Clin Psychiatry. 2005;66(Suppl. 9):18–23
  10. Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004;23:932–946
  11. Ranlov PJ, Nielsen SP. Effect of zopiclone and diazepam on ventilatory response in normal human subjects. Sleep. 1987;10(Suppl. 1):40–47
  12. Berry RB, McCasland CR, Light RW. The effect of triazolam on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis. 1992;146:1256–1260
  13. Leiter JC, Knuth SL, Krol RC, Bartlett D. The effect of diazepam on genioglossal muscle activity in normal human subjects. Am Rev Respir Dis. 1985;132:216–219
  14. Murciano D, Armengaud MH, Cramer PH, et al. Acute effects of zolpidem, triazolam and flunitrazepam on arterial blood gases and control of breathing in severe COPD. Eur Respir J. 1993;6:625–629
  15. Midgren B, Hansson L, Skeidsvoll H, Elmqvist D. The effects of nitrazepam and flunitrazepam on oxygen desaturation during sleep in patients with stable hypoxemic nonhypercapnic COPD. Chest. 1989;95:765–768
  16. Steens RD, Pouliot Z, Millar TW, Kryger MH, George CF. Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonary disease. Sleep. 1993;16:318–326
  17. Timms RM, Dawson A, Hajdukovic RM, Mitler MM. Effect of triazolam on sleep and arterial oxygen saturation in patients with chronic obstructive pulmonary disease. Arch Intern Med. 1988;148:2159–2163
  18. Wedzicha JA, Wallis PJ, Ingram DA, Empey DW. Effect of diazepam on sleep in patients with chronic airflow obstruction. Thorax. 1988;43:729–730
  19. Global Initiative for Chronic Obstructive Lung Disease (GOLD) . Executive summary: Global strategy for the diagnosis, management, and prevention of COPD. Accessed at: www.goldcopd.comLast updated: 2007
  20. Cuanang JR, Limos L. Treatment of insomnia with temazepam: double-blind, placebo-controlled evaluation. Clin Ther. 1982;4:402–412
  21. College voor Zorgverzekeringen. Farmacotheurapeutisch kompas . 2008. Accessible at: www.fk.cvz.nl
  22. Yska JP, Essink GW, Bosch FH, Lankhaar G, van Sorge AA. Oral bioavailability of phenobarbital: a comparison of a solution in Myvacet 9-08, a suspension, and a tablet. Pharm World Sci. 2000;22:67–71
  23. Smolders FD, Folgering HT, Bernards JA. Capnostat and oxystat. Electronic devices to automatically maintain the end-tidal PCO2 and PO2 of a subject connected to a closed respiratory circuit at adjustable levels. Pflugers Arch. 1977;372:289–290
  24. Thorpy MJ. The clinical use of the Multiple Sleep Latency Test. The Standards of Practice Committee of the American Sleep Disorders Association. Sleep. 1992;15:268–276
  25. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14:540–545
  26. Leitch AG, Clancy LJ, Leggett RJ, Tweeddale P, Dawson P, Evans JI. Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure. Thorax. 1976;31:730–735
  27. O'Donoghue FJ, Catcheside PG, Ellis EE, et al. Sleep hypoventilation in hypercapnic chronic obstructive pulmonary disease: prevalence and associated factors. Eur Respir J. 2003;21:977–984
  28. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages of Human Subjects. Los Angeles: US Department of Health, Education, and Welfare Public Health Service – NIH/NIND; 1968;
  29. Parker SM, Gibson GJ. Evaluation of a transcutaneous carbon dioxide monitor (“TOSCA”) in adult patients in routine respiratory practice. Respir Med. 2007;101:261–264
  30. Senn O, Clarenbach CF, Kaplan V, Maggiorini M, Bloch KE. Monitoring carbon dioxide tension and arterial oxygen saturation by a single earlobe sensor in patients with critical illness or sleep apnea. Chest. 2005;128:1291–1296
  31. Bernet-Buettiker V, Ugarte MJ, Frey B, Hug MI, Baenziger O, Weiss M. Evaluation of a new combined transcutaneous measurement of PCO2/pulse oximetry oxygen saturation ear sensor in newborn patients. Pediatrics. 2005;115:e64–68
  32. Stege G, van den Elshout FJ, Heijdra YF, van de Ven MJ, Dekhuijzen PN, Vos PJ. Accuracy of transcutaneous carbon dioxide tension measurements during cardiopulmonary exercise testing. Respiration. 2009;78:147–153
  33. Dundar Y, Dodd S, Strobl J, Boland A, Dickson R, Walley T. Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis. Hum Psychopharmacol. 2004;19:305–322
  34. Van de Ven MJ, Colier WN, Van der Sluijs MC, Kersten BT, Oeseburg B, Folgering H. Ventilatory and cerebrovascular responses in normocapnic and hypercapnic COPD patients. Eur Respir J. 2001;18:61–68

☆ This study was registered at www.ClinicalTrials.gov as ‘Effects of temazepam in patients with chronic pulmonary obstructive disease’ (ID number NCT00245661).

PII: S0954-6111(09)00357-6

doi: 10.1016/j.rmed.2009.10.022

Respiratory Medicine
Volume 104, Issue 4 , Pages 518-524 , April 2010

Article Tools

* Image Usage & Resolution