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Respiratory Medicine
Volume 104, Issue 5
, Pages 668-674
, May 2010
Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: A randomised controlled trial
References
- . Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem. 1997;272(45):28210–28217
- Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT 4 as measured by photoaffinity labeling. Diabetes. 1995;44:1087–1092
- . Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling. Am J Respir Crit Care Med. 2001;164(8 Pt 1):1487–1494
- . Peroxisome proliferator-activated receptors as novel targets in lung disease. Chest. 2008;134(1):152–157
- . Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma. Clin Pharmacol Ther. 2009;86(1):49–53
- . Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease. PPAR Res. 2007;2007:14983
- . PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res. 2002;90(6):703–710
- . Expression of PPARgamma in eosinophils and its functional role in survival and chemotaxis. Immunol Lett. 2003;86(2):183–189
- . Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys. 2003;418(2):186–196
- . Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med. 2003;198(3):411–421
- . PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003;139(1):163–171
- . Improvement of asthma after administration of pioglitazone. Diabetes Care. 2002;25(2):401
- Identification of high-affinity binding sites for the insulin-sensitizer rosiglitazone (BRL 49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J Pharmacol Exp Ther. 1998;284:751–759
- . Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands. Anal Biochem. 2005;344(1):8–15
- . Bronchial and bronchoalveolar inflammation in single early and dual responders after allergen inhalation challenge. Lungs. 1997;175(4):277–285
- . Course of non-specific bronchial reactivity to histamine after bronchospasm induced by allergen challenge in patients with bronchial asthma. Pneumonol Alergol Pol. 1995;63(5–6):273–280
- . ERS Task Force. Indirect airway challenges. Eur Respir J. 2003;21(6):1050–1068
- . Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. Am J Respir Crit Care Med. 2001;164(7):1127–1132
- . Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab. 2004;89(6):2728–2735
- . Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care. 2002;25(2):376–380
- . Rosiglitazone Clinical Trials Study Group. Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes. Diabetes Care. 2001;24(2):308–315
- Evaluation of single-dose inhaled corticosteroid activity with an allergen challenge model. J Allergy Clin Immunol. 1997;100:65–70
- . Differential effects of fluticasone and montelukast on allergen-induced asthma. Allergy. 2005;60:65–70
- . Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med. 2007;176(10):988–993
- . Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J. 1993;6:1368–1370
- Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343:133–135
- . The allergen challenge. Clin Exp Allergy. 2002;32(2):162–167
- . Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma. Thorax. 1999 May;54(5):403–408
- . Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide. J Pharmacol Exp Ther. 2005;312(1):69–76
- . Corticosteroid insensitivity in smokers with asthma: clinical evidence, mechanisms, and management. Treat Respir Med. 2006;5(6):467–481
PII: S0954-6111(09)00370-9
doi: 10.1016/j.rmed.2009.11.006
© 2009 Elsevier Ltd. All rights reserved.
« Previous
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Respiratory Medicine
Volume 104, Issue 5
, Pages 668-674
, May 2010
