Respiratory Medicine
Volume 104, Issue 4 , Pages 564-570 , April 2010

Elevated 1, 25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis

  • Dashant Kavathia

      Affiliations

    • Henry Ford Hospital, Division of Pulmonary and Critical Care Medicine, K 17, 2799 W Grand Blvd, Detroit, MI 48202, USA
  • ,
  • John D. Buckley

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Indiana University, Indianapolis, IN, USA
  • ,
  • Dhanwada Rao

      Affiliations

    • Division of Endocrinology, Henry Ford Health System, Detroit, MI, USA
  • ,
  • Benjamin Rybicki

      Affiliations

    • Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, USA
  • ,
  • Robert Burke

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Henry Ford Health System, Detroit, MI, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 (313) 916 2436; fax: +1 (313) 916 9102.

Received 23 July 2009 ,Accepted 7 December 2009.

References 

  1. Hunninghake GW, Costabel U, Ando M, et al. ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis. 1999;16:149–173
  2. Judson MA. The etiologic agent of sarcoidosis: what if there isn't one?. Chest. 2003;124:6–8
  3. Baughman RP, Teirstein AS, Judson MA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885–1889
  4. Papapoulos SE, Clemens TL, Fraher LJ, Lewin IG, Sandler LM, O'Riordan JL. 1, 25-dihydroxycholecalciferol in the pathogenesis of the hypercalcaemia of sarcoidosis. Lancet. 1979;1:627–630
  5. Bell NH, Stern PH, Pantzer E, Sinha TK, DeLuca HF. Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest. 1979;64:218–225
  6. Adams JS, Sharma OP, Gacad MA, Singer FR. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856–1860
  7. Mason RS, Frankel T, Chan YL, Lissner D, Posen S. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med. 1984;100:59–61
  8. Koeffler HP, Reichel H, Bishop JE, Norman AW. gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages. Biochem Biophys Res Commun. 1985;127:596–603
  9. Reichel H, Koeffler HP, Barbers R, Norman AW. Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J Clin Endocrinol Metab. 1987;65:1201–1209
  10. Reichel H, Koeffler HP, Tobler A, Norman AW. 1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A. 1987;84:3385–3389
  11. Willheim M, Thien R, Schrattbauer K, et al. Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J Clin Endocrinol Metab. 1999;84:3739–3744
  12. Rigby WF, Denome S, Fanger MW. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest. 1987;79:1659–1664
  13. Rigby WF, Stacy T, Fanger MW. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest. 1984;74:1451–1455
  14. Provvedini DM, Manolagas SC. 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes. J Clin Endocrinol Metab. 1989;68:774–779
  15. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol. 2001;167:1945–1953
  16. Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini LA. 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes. 2002;51:1367–1374
  17. Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol. 2008;181:7090–7099
  18. Prasse A, Katic C, Germann M, Buchwald A, Zissel G, Muller-Quernheim J. Phenotyping sarcoidosis from a pulmonary perspective. Am J Respir Crit Care Med. 2008;177:330–336
  19. Wasfi YS, Rose CS, Murphy JR, et al. A new tool to assess sarcoidosis severity. Chest. 2006;129:1234–1245
  20. Scadding JG. Sarcoidosis, with special reference to lung changes. BMJ. 1950;1:745–753
  21. Rao DS. Perspective on assessment of vitamin D nutrition. J Clin Densitom. 1999;2:457–464
  22. Adorini L. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes. Ann N Y Acad Sci. 2003;987:258–261
  23. Gorman S, Kuritzky LA, Judge MA, et al. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J Immunol. 2007;179:6273–6283
  24. Ardalan MR, Maljaei H, Shoja MM, et al. Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients. Transplant Proc. 2007;39:951–953
  25. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–281
  26. Zadshir A, Tareen N, Pan D, Norris K, Martins D. The prevalence of hypovitaminosis D among US adults: data from the NHANES III. Ethn Dis. 2005;15(S5):97–101
  27. Guardia G, Parikh N, Eskridge T, Phillips E, Divine G, Rao DS. Prevalence of vitamin D depletion among subjects seeking advice on osteoporosis: a five-year cross-sectional study with public health implications. Osteoporos Int. 2008;19:13–19
  28. Kleerekoper M, Nelson DA, Peterson EL, et al. Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55–75) postmenopausal white and black women. J Bone Miner Res. 1994;9:1267–1276
  29. Harris SS. Vitamin D and African Americans. J Nutr. 2006;136:1126–1129
  30. Engelman CD, Fingerlin TE, Langefeld CD, et al. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93:3381–3388
  31. Burke RR, Stone CH, Havstad S, Rybicki BA. Racial differences in sarcoidosis granuloma density. Lung. 2008;
  32. Dusso AS, Kamimura S, Gallieni M, et al. gamma-Interferon-induced resistance to 1,25-(OH)2 D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses. J Clin Endocrinol Metab. 1997;82:2222–2232
  33. Judson MA, Thompson BW, Rabin DL, et al. The diagnostic pathway to sarcoidosis. Chest. 2003;123:406–412
  34. Edmondstone WM, Wilson AG. Sarcoidosis in Caucasians, Blacks and Asians in London. Br J Dis Chest. 1985;79:27–36

PII: S0954-6111(09)00407-7

doi: 10.1016/j.rmed.2009.12.004

Respiratory Medicine
Volume 104, Issue 4 , Pages 564-570 , April 2010