Respiratory Medicine
Volume 104, Issue 6 , Pages 788-793, June 2010

A single dose of Sildenafil does not enhance FeNO: A randomised, cross-over and placebo-controlled study

  • Thomas Rothe

      Affiliations

    • Zürcher Höhenklinik Davos, Klinikstrasse, CH-7272 Davos Clavadel, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +41 81 4144103.
    • ,
  • Werner Karrer

      Affiliations

    • Luzerner Hoehenklinik Montana, Route d'Astoria, CH-3963 Crans-Montana, Switzerland
    • ,
  • Christian Schindler

      Affiliations

    • Institut für Sozial-und Präventivmedizin, Universität Basel, Steinengraben 49, CH-4051 Basel, Switzerland

Received 21 June 2009; accepted 22 December 2009. published online 15 January 2010.

Summary 

Monitoring of asthma control can be performed with different means including measurement of the concentration of nitric oxide (NO) in exhaled air. Due to its action on the NO-metabolism; we hypothesized that the intake of Sildenafil might augment and falsify the NO-values in exhaled air of subjects taking the drug to treat erectile dysfunction.

This randomised, placebo-controlled cross-over study including 10 male non-asthmatic volunteers taking a single dose of 50 mg Sildenafil did not confirm this assumption in non-asthmatic subjects. We cannot think of any reason why asthmatics should behave differently.

On the basis of these results, it does not seem necessary to ask asthma patients with elevated NO-values if they had taken any selective inhibitor of the cGMP-specific phosphodiesterase Type 5 as Sildenafil prior to the test.

Keywords: Asthma, Asthma control, Exhaled nitric oxide, Sildenafil

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PII: S0954-6111(09)00434-X

doi:10.1016/j.rmed.2009.12.011

Respiratory Medicine
Volume 104, Issue 6 , Pages 788-793, June 2010

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