Association between polymorphism of glutathione S-transferase P1 and chronic obstructive pulmonary disease: A meta-analysis
Received 15 January 2009; accepted 10 January 2010. published online 01 February 2010.
Summary
Background
It was proposed that glutathione S-transferase P1 (GSTP1) gene involved in detoxification of electrophilic substances may be related with lung function. The present study aimed at investigating the correlation between GSTP1 105Val/Val genotype and chronic obstruct pulmonary disease (COPD) using a meta-analysis of existed studies.
Methods
The Embase, Ovid, and PubMed databases were searched to identify eligible studies published before October 1, 2009. Data were extracted using standardized forms and the pooled odds ratios (ORs) with 95% confidence intervals (CI) were assessed by a model of fixed- or random effects.
Results
The values of odds ratios(ORs) for COPD were 0.634 (95%CI 0.426–0.943, p = 0.025) in GSTP1 Ile/Ile, 0.625 (95%CI 0.418–0.935, p = 0.022) in GSTP1 Ile/Val, and 0.633 (95% CI 0.430–0.933, p = 0.021) in both, as compared to GSTP1 Val/Val, respectively. The individuals with GSTP1 105Ile/Ile, Ile/Val, and both have about 37% reduction in the odds of COPD, as compared to individuals with GSTP1 105Val/Val.
Conclusions
The GSTP1 105Val/Val genotype is suggested to be a genetic contributor to COPD susceptibility, which should be furthermore clarified by studies with large sample sizes and careful control for age, sex, ethnicity, and cigarette smoking.
aDepartment of Respiratory Medicine, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, PR China
bDepartment of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University Institute of Respiratory Diseases, Hangzhou, PR China
cDepartment of Respiratory Medicine and Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, PR China
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