Respiratory Medicine
Volume 104, Issue 7 , Pages 1042-1049 , July 2010

Pulmonary inflammation in asbestos-exposed subjects with borderline parenchymal changes on HRCT

  • Lauri Lehtimäki

      Affiliations

    • The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
    • The Research Unit, Tampere University Hospital, Finland
    • Department of Respiratory Medicine, Tampere University Hospital, Finland
    • Corresponding Author InformationCorresponding author at: Department of Pharmacology, Medical School, FIN-33014, University of Tampere, Tampere, Finland. Tel.: +358 3 35518081; fax: +358 3 35518082.
  • ,
  • Panu Oksa

      Affiliations

    • Department of Occupational Medicine, Tampere University Hospital, Finland
    • Finnish Institute of Occupational Health, Tampere, Finland
  • ,
  • Ritva Järvenpää

      Affiliations

    • Department of Radiology, Tampere University Hospital, Finland
  • ,
  • Tuula Vierikko

      Affiliations

    • Department of Radiology, Tampere University Hospital, Finland
  • ,
  • Riina Nieminen

      Affiliations

    • The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
    • The Research Unit, Tampere University Hospital, Finland
  • ,
  • Hannu Kankaanranta

      Affiliations

    • The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
    • Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland
  • ,
  • Jukka Uitti

      Affiliations

    • Department of Occupational Medicine, Tampere University Hospital, Finland
    • Finnish Institute of Occupational Health, Tampere, Finland
  • ,
  • Eeva Moilanen

      Affiliations

    • The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
    • The Research Unit, Tampere University Hospital, Finland

Received 23 June 2009 ,Accepted 27 January 2010.

References 

  1. Manning CB, Vallyathan V, Mossman BT. Diseases caused by asbestos: mechanisms of injury and disease development. Int Immunopharmacol. 2002;2:191–200
  2. American Thoracic Society . Diagnosis and initial management of nonmalignant diseases related to asbestos. Am J Respir Crit Care Med. 2004;170:691–715
  3. Oksa P, Suoranta H, Koskinen H, Zitting A, Nordman H. High-resolution computed tomography in the early detection of asbestosis. Int Arch Occup Environ Health. 1994;65:299–304
  4. Paris C, Benichou J, Raffaelli C, et al. Factors associated with early-stage pulmonary fibrosis as determined by high-resolution computed tomography among persons occupationally exposed to asbestos. Scand J Work Environ Health. 2004;30:206–214
  5. Huuskonen O, Kivisaari L, Zitting A, Taskinen K, Tossavainen A, Vehmas T. High-resolution computed tomography classification of lung fibrosis for patients with asbestos-related disease. Scand J Work Environ Health. 2001;27:106–112
  6. Kusaka Y, Hering KG, Parker JE. International classification of HRCT for occupational and environmental respiratory diseases. Tokyo: Springer-Verlag; 2005;
  7. Gamsu G, Salmon CJ, Warnock ML, Blanc PD. CT quantification of interstitial fibrosis in patients with asbestosis: a comparison of two methods. AJR Am J Roentgenol. 1995;164:63–68
  8. Kharitonov SA, Barnes PJ. Exhaled biomarkers. Chest. 2006;130:1541–1546
  9. Tsoukias NM, George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl Physiol. 1998;85:653–666
  10. Lehtimäki L, Kankaanranta H, Saarelainen S, et al. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am J Respir Crit Care Med. 2001;163:1557–1561
  11. Brindicci C, Ito K, Resta O, Pride NB, Barnes PJ, Kharitonov SA. Exhaled nitric oxide from lung periphery is increased in COPD. Eur Respir J. 2005;26:52–59
  12. Brindicci C, Ito K, Barnes PJ, Kharitonov SA. Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest. 2007;131:1353–1362
  13. Lehtimäki L, Kankaanranta H, Saarelainen S, Turjanmaa V, Moilanen E. Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms. Eur Respir J. 2002;20:841–845
  14. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989;84:1609–1619
  15. Janssen LJ. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1067–L1082
  16. Lehtonen H, Oksa P, Lehtimäki L, et al. Increased alveolar nitric oxide concentration and high levels of leukotriene B(4) and 8-isoprostane in exhaled breath condensate in patients with asbestosis. Thorax. 2007;62:602–607
  17. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26:319–338
  18. Koskinen K, Pukkala E, Martikainen R, Reijula K, Karjalainen A. Different measures of asbestos exposure in estimating risk of lung cancer and mesothelioma among construction workers. J Occup Environ Med. 2002;44:1190–1196
  19. Macintyre N, Crapo RO, Viegi G, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 2005;26:720–735
  20. Sandrini A, Johnson AR, Thomas PS, Yates DH. Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaques. Respirology. 2006;11:325–329
  21. Park SH, Aust AE. Regulation of nitric oxide synthase induction by iron and glutathione in asbestos-treated human lung epithelial cells. Arch Biochem Biophys. 1998;360:47–52
  22. Malinovschi A, Janson C, Holmkvist T, Norbäck D, Meriläinen P, Högman M. Effect of smoking on exhaled nitric oxide and flow-independent nitric oxide exchange parameters. Eur Respir J. 2006;28:339–345
  23. Garcia JG, Griffith DE, Cohen AB, Callahan KS. Alveolar macrophages from patients with asbestos exposure release increased levels of leukotriene B4. Am Rev Respir Dis. 1989;139:1494–1501
  24. Tulinska J, Jahnova E, Dusinska M, et al. Immunomodulatory effects of mineral fibres in occupationally exposed workers. Mutat Res. 2004;553:111–124
  25. Haegens A, van der Vliet A, Butnor KJ, et al. Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. Cancer Res. 2005;65:9670–9677
  26. Schabath MB, Spitz MR, Delclos GL, Gunn GB, Whitehead LW, Wu X. Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk. Am J Ind Med. 2002;42:29–37
  27. Neri S, Antonelli A, Falaschi F, Boraschi P, Baschieri L. Findings from high resolution computed tomography of the lung and pleura of symptom free workers exposed to amosite who had normal chest radiographs and pulmonary function tests. Occup Environ Med. 1994;51:239–243

PII: S0954-6111(10)00046-6

doi: 10.1016/j.rmed.2010.01.019

Respiratory Medicine
Volume 104, Issue 7 , Pages 1042-1049 , July 2010