Respiratory Medicine
Volume 104, Issue 7 , Pages 945-950 , July 2010

The link between exhaled NO and bronchomotor tone depends on the dose of inhaled steroid in asthma

  • Bruno Mahut

      Affiliations

    • Cabinet La Berma, 4 avenue de la Providence, 92 160 Antony, France
    • Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie – Clinique de la Dyspnée, Paris, France
    • Mosquito Respiratory Research Group, Paris, France
    • ,
  • Ludovic Trinquart

      Affiliations

    • Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité de Recherche Clinique et d'Epidémiologie, Paris, France
    • Mosquito Respiratory Research Group, Paris, France
    • University Paris Descartes, Paris, France
    • ,
  • Plamen Bokov

      Affiliations

    • Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie – Clinique de la Dyspnée, Paris, France
    • Mosquito Respiratory Research Group, Paris, France
    • ,
  • Claudine Peiffer

      Affiliations

    • Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie – Clinique de la Dyspnée, Paris, France
    • Mosquito Respiratory Research Group, Paris, France
    • ,
  • Christophe Delclaux

      Affiliations

    • Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie – Clinique de la Dyspnée, Paris, France
    • Mosquito Respiratory Research Group, Paris, France
    • University Paris Descartes, Paris, France
    • CIC 9201 Plurithématique, Hôpital Européen Georges Pompidou, Paris, France
    • Corresponding Author InformationCorresponding author. Service de Physiologie – Clinique de la Dyspnée, Hôpital Européen Georges Pompidou, 20, rue Leblanc; 75015 Paris, France. Tel.: +33 1 56 09 34 88.

Received 28 September 2009 ,Accepted 3 February 2010.

References 

  1. Jatakanon A, Kharitonov S, Lim S, Barnes PJ. Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma. Thorax. 1999;54:108–114
  2. Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Dose–response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest. 2001;119:1322–1328
  3. Taylor DR, Pijnenburg MW, Smith AD, De Jongste JC. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax. 2006;61:817–827
  4. Mahut B, Delclaux C, Tillie-Leblond I, et al. Both inflammation and remodeling influence nitric oxide output in children with refractory asthma. J Allergy Clin Immunol. 2004;113:252–256
  5. van Rensen EL, Straathof KC, Veselic-Charvat MA, Zwinderman AH, Bel EH, Sterk PJ. Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma. Thorax. 1999;54:403–408
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  7. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol Rev. 2004;84:731–765
  8. Mahut B, Trinquart L, Le Bourgeois M, et al. Multicentre trial evaluating alveolar NO fraction as a marker of asthma control and severity. Allergy. 2009;[E-Pub]
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  12. Mahut B, Trinquart L, Bokov P, et al. Relationships between specific airway resistance and forced expiratory flows in asthmatic children. PLoS One. 2009;4:e5270
  13. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26:948–968
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  16. Pijnenburg MW, Bakker EM, Lever S, Hop WC, De Jongste JC. High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children. Clin Exp Allergy. 2005;35:920–925
  17. Ho LP, Wood FT, Robson A, Innes JA, Greening AP. The current single exhalation method of measuring exhales nitric oxide is affected by airway calibre. Eur Respir J. 2000;15:1009–1013
  18. Silvestri M, Sabatini F, Sale R, et al. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals. Pediatr Pulmonol. 2003;35:358–363
  19. Spahn JD, Cherniack R, Paull K, Gelfand EW. Is forced expiratory volume in one second the best measure of severity in childhood asthma?. Am J Respir Crit Care Med. 2004;169:784–786
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PII: S0954-6111(10)00054-5

doi: 10.1016/j.rmed.2010.02.003

Respiratory Medicine
Volume 104, Issue 7 , Pages 945-950 , July 2010

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