Respiratory Medicine
Volume 104, Issue 8 , Pages 1131-1137 , August 2010

Increased serum IL-17 is an independent risk factor for severe asthma

  • Ioana Agache

      Affiliations

    • Transylvania University, Faculty of Medicine, Department of Allergy and Clinical Immunology; B-ul Eroilor 29, Brasov 500036, Romania
    • Corresponding Author InformationCorresponding author. Spatarul Luca Arbore 16, Brasov 500112, Romania. Tel.: +40 727 849321; fax: +40 268 471814.
    • ,
  • Cristina Ciobanu

      Affiliations

    • Theramed Medical Center, Department of Allergy and Clinical Immunology; Spatarul Luca Arbore 16, Brasov 500112, Romania
    • ,
  • Costel Agache

      Affiliations

    • Theramed Medical Center, Department of Allergy and Clinical Immunology; Spatarul Luca Arbore 16, Brasov 500112, Romania
    • ,
  • Mariana Anghel

      Affiliations

    • Brasov County Hospital, Immunology Lab; Calea Bucuresti 25-27, Brasov 500326, Romania

Received 30 November 2009 ,Accepted 21 February 2010.

References 

  1. Tato CM, O'Shea J. What does it mean to be just 17?. Nature. 2006;441:166–168
  2. Pène J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol. 2008;180(11):7423–7430
  3. Wakashin H, Hirose K, Maezawa Y, et al. IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med. 2008;178(10):1023–1032
  4. Bullens DM, Truyen E, Coteur L, et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?. Respir. Res. 2006;7:135
  5. Laan M, Lotvall J, Chung KF, Linden A. IL-17F induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases. Br J Pharmacol. 2001;133(1):200–206
  6. Molet S, Hamid Q, Davoine F, Nutku E, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol. 2001;108(3):430–438
  7. Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med. 2003;97(6):726–733
  8. Kaminska M, Foley S, Maghni K, et al. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol. 2009;124(1):45–51e1-4
  9. Kasayama S, Tanemura M, Koga M, Fujita K, Yamamoto H, Miyatake A. Asthma is an independent risk for elevation of plasma C-reactive protein levels. Clin Chim Acta. 2009;399(1–2):79–82
  10. Qian FH, Zhang Q, Zhou LF, et al. High-sensitivity C-reactive protein: a predicative marker in severe asthma. Respirology. 2008;13(5):664–669
  11. Zietkowski Z, Tomasiak-Lozowska MM, Skiepko R, Mroczko B, Szmitkowski M, Bodzenta-Lukaszyk A. High-sensitivity C-reactive protein in the exhaled breath condensate and serum in stable and unstable asthma. Respir Med. 2009;103(3):379–385
  12. Wong CK, Ho CY, Ko FW, et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol. 2001;125(2):177–183
  13. Saito H, Tsurikisawa N, Tsuburai T, Oshikata C, Akiyama K. Cytokine production profile of CD4+ T cells from patients with active Churg–Strauss syndrome tends toward Th17. Int Arch Allergy Immunol. 2009;149(Suppl. 1):61–65
  14. ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med. 2001;164(5):744–748
  15. Lee JH, Haselkorn T, Borish L, et al. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest. 2007;132(6):1882–1889

PII: S0954-6111(10)00088-0

doi: 10.1016/j.rmed.2010.02.018

Respiratory Medicine
Volume 104, Issue 8 , Pages 1131-1137 , August 2010

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