Respiratory Medicine
Volume 104, Issue 10 , Pages 1444-1449 , October 2010

Resting respiratory variables and exercise capacity in adult patients with cystic fibrosis

  • G. Perpati

      Affiliations

    • Cystic Fibrosis Outpatient Clinic, Athens Chest Hospital, Mesogion 152, Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 6936537116.
    • ,
  • S. Nanas

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece
    • ,
  • E. Pouliou

      Affiliations

    • Cystic Fibrosis Outpatient Clinic, Athens Chest Hospital, Mesogion 152, Athens, Greece
    • ,
  • V. Dionyssopoulou

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece
    • ,
  • E. Stefanatou

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece
    • ,
  • E. Armeniakou

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece
    • ,
  • A. Papamichalopoulos

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece
    • ,
  • Ch. Roussos

      Affiliations

    • Department of Pulmonary and Critical Care Medicine, National and Kapodistrian University, Athens, Greece

Received 15 April 2009 ,Accepted 25 May 2010.

References 

  1. Vankeerberghen A, Cuppens H, Cassiman JJ. The cystic fibrosis transmembrane conductance regulator: an intriguing protein with pleiotropic functions. J Cyst Fibros. 2002;1:13–29
  2. Kabra SK, Kabra M, Lodha R, Shastri S. Cystic fibrosis in India. Pediatr Pulmonol. 2007;42(12):1087–1094
  3. Stern M, Sens B, Wiedemann B, Busse O, Damm G, Wenzlaff P. Qualitätssicherung Mukoviszidose. Überblick über den Gesundheitszustand der Patienten in Deutschland 2005. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft; 2007;
  4. Foundation CF. Cystic fibrosis foundation patient registry annual data report for 2004. Cystic Fibrosis Foundation; 2005;
  5. Sawicki GS, Sellers DE, Robinson WM. High treatment burden in adults with cystic fibrosis: Challenges to disease self-management. J Cyst Fibros. 2008 Oct 24;[Epub ahead of print]
  6. Hewer SC, Tyrrell J. Cystic fibrosis and the transition to adult health services. Arch Dis Child. 2008;93(10):817–821
  7. Sawicki GS, Dill EJ, Asher D, Sellers DE, Robinson WM. Advanced care planning in adults with cystic fibrosis. J Palliat Med. 2008;11(8):1135–1141
  8. Hodson ME. In:  Hodson ME,  Geddes DM editor. Adults, 10b, Cystic fibrosis. 2nd ed.. 2000;p. 218–222
  9. Regnis JA, Alison JA, Henke KG, Donelly PM, Bye PTP. Changes in end-expiratory lung volume during exercise in cystic fibrosis relate to severity of lung disease. Am Rev Respir Dis. 1991;144:507–512
  10. Goetghebeur D, et al. Tidal expiratory flow limitation and chronic dyspnoea in patients with cystic fibrosis. Eur Respir J. 2002;19:492–498
  11. Van Haren , et al. Bronchodilator response in patients with cystic fibrosis: effects on large and small airways. Eur Respir J. 1991 Mar;4(3):301–307
  12. Holland AE, Denehy L, Wilson JW. Does expiratory flow limitation predict chronic dyspnoea in adult patients with cystic fibrosis?. Eur Respir J. 2006;28:96–101
  13. Tantucci C, Duguet A, Similowski T, Zelter M, Derenne JP, Milic-Emil J. Effect of salbutamol on dynamic pulmonary hyperinflation in chronic obstructive lung disease patients. Eur Respir J. 1998;12:799–804
  14. Diaz O, Villafranca C, Ghezzo H, et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest. Eur Respir J. 2000;16:269–275
  15. Koulouris NG, Dimopoulou I, Valta P, Finkelstein R, Cosio MG, Milic-Emili J. Detection of expiratory flow limitation during exercise in COPD patients. J Appl Physiol. 1997;82:723–731
  16. O’Donnell DE, Webb KA. Exertional breathlessness in patients with chronic airflow limitation: role of lung hyperinflation. Am Rev Respir Dis. 1993;148:1351–1357
  17. Schwachman H, Kulczyski LL. Long term study of 105 patients with cystic fibrosis made over a five to fourteen year period. Am J Dis Child. 1958;96:6–15
  18. Mairel Janet R, Frost Adam E, Estenne Marc, Higenbottam Timothy, Glanville Allan R. International guidelines for the selection of lung transplant candidates. Transplantation. 1998;66(7):951–956
  19. Nixon PA, Orenstein DM, Kelsey SF, Doershuk CF. The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med. 1992;327:1785–1788
  20. Pouliou E, Nanas S, Papamichalopoulos A, et al. Prolonged oxygen kinetics during early recovery from maximal exercise in adult patients with cystic fibrosis. Chest. 2001 Apr;119(4):1073–1078
  21. McKone EF, Barry SC, FitzGerald MX, Gallagher CG. Reproducibility of maximal exercise ergometer testing in patients with cystic fibrosis. Chest. 1999;116(2):363–368
  22. American Thoracic Society . Standardization of spirometry, 1995 update. Am Rev Resp Dis. 1995;152:1107–1136
  23. Marin JM, Carrizo SJ, Gascon M, et al. Inspiratory capacity, dynamic hyperinflation, breathlessness and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:1395–1399
  24. Naughton J, Sevellus G, Balke B. Physiological responses of normal and pathologic subjects to a modified work capacity test. J Sports Med. 1963;31:201
  25. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol. 1986;60:2020–2027
  26. Godfrey S, Mearns M. Pulmonary function and response to exercise in cystic fibrosis. Arch Dis Child. 1971;46:144–151
  27. Browning B, D’Alonso GE, Tobin MJ. Importance of respiratory rate as an indicator of respiratory dysfunction in patients with cystic fibrosis. Chest. June 1990;97(6):1317–1321
  28. Lands LC, Heigenhauser GJ, Jones NL. Analysis of factors limiting maximal exercise performance in cystic fibrosis. Clin Sci. 1992;83:391–397
  29. Nixon PA, Orenstein DM, Kelsey SF, et al. The prognostic value of exercise testing in patients with cystic fibrosis. NEJM. 1992;327:1785–1788
  30. Moorcroft J, Dodd ME, Webb AK. Exercise testing and prognosis in adult cystic fibrosis. Thorax. 1997;52:291–293
  31. Webb AK, Dodd ME, Moorcroft J. Exercise and cystic fibrosis. J R Soc Med. 1995;88(Suppl. 25):30–36
  32. Younes M. Load responses, dyspnea and respiratory failure. Chest. 1990;97:59S–68S

PII: S0954-6111(10)00252-0

doi: 10.1016/j.rmed.2010.05.016

Respiratory Medicine
Volume 104, Issue 10 , Pages 1444-1449 , October 2010

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