Respiratory Medicine
Volume 104, Issue 12 , Pages 1937-1942 , December 2010

Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer – A retrospective single institution analysis

  • Andreas Hermes

      Affiliations

    • Dept. of Thoracic Oncology, Grosshansdorf Hospital, Woehrendamm 80, 22927 Grosshansdorf, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 4102 6010; fax: +49 4102 601343.
  • ,
  • Ulrich Gatzemeier

      Affiliations

    • Dept. of Thoracic Oncology, Grosshansdorf Hospital, Woehrendamm 80, 22927 Grosshansdorf, Germany
  • ,
  • Benjamin Waschki

      Affiliations

    • Pulmonary Research Institute, Grosshansdorf Hospital, Grosshansdorf, Germany
  • ,
  • Martin Reck

      Affiliations

    • Dept. of Thoracic Oncology, Grosshansdorf Hospital, Woehrendamm 80, 22927 Grosshansdorf, Germany

Received 26 May 2010 ,Accepted 21 July 2010.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics 2008. CA Cancer J Clin. 2008;58:71–96
  2. Slotman B, Faivre-Finn C, Kramer G, et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 2007;357:664–672
  3. Hyde L, Wolf J, Mc Cracken S. Natural course of inoperable lung cancer. Chest. 1973;64:309–312
  4. Stanley KE. Prognostic factors in lung cancer. In:  Aisner J editors. Lung cancer. New York, NY: Churchill Livingstone; 1985;p. 41–66
  5. Ohnoshi T, Hiraki S, Nakata Y, et al. Pretreatment serum albumin concentration and lactic dehydrogenase activity as prognostic factors in patients with small cell lung cancer. Acta Med Okayama. 1982;36:487–490
  6. Sculier JP, Feld R, Evans WK, et al. Carcinoembryonic antigen: a useful prognostic marker in small cell lung cancer. J Clin Oncol. 1985;3:1349–1354
  7. Carney DN, Ihde DC, Cohen MH, et al. Serum neuron specific enolase: a marker for disease extent and response to therapy of small cell carcinoma. Lancet. 1982;1:583–585
  8. Wang T, Feld R, Sagman U, et al. The combined use of LDH and CEA as independent prognostic markers for small cell lung cancer. Proc Am Assoc Cancer Res. 1986;27:162;abstr 641
  9. Hagberg H, Siegbahn A. Prognostic level of serum lactic dehydrogenase in non-Hodgkin’s lymphoma. Scand J Haematol. 1983;31:49–65
  10. Brereton HD, Simon R, Pomeroy TC. Pretreatment lactate dehydrogenase predicting metastatic spread in Ewing’s sarcoma. Ann Intern Med. 1975;83:352–354
  11. Simonsson B, Grenning G, Kallander C, et al. Prognostic level of serum lactic dehydrogenase (S-LDH) in multiple myeloma. Eur J Clin Invest. 1987;17:336–339
  12. Barlogie B, Smallwood L, Smith T, et al. High serum levels of lactic dehydrogenase identify a high-grade lymphoma-like myeloma. Ann Intern Med. 1989;110:521–525
  13. Schilling RF, McKnight B, Crowley JJ. Prognostic level of serum lactate dehydrogenase level in Hodgkin’s disease. J Lab Clin Med. 1982;99:382–387
  14. Souhami RL, Bradbury J, Geddes DM, et al. Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res. 1985;45:2878–2882
  15. Cohen MH, Makuch R, Johnston-Early A, et al. Laboratory parameters as an alternative to performance status in prognostic stratification of patients with small cell lung cancer. Cancer Treat Rep. 1981;65:187–195
  16. Maurer LH, Pajak TF. Prognostic factors in small cell carcinoma of the lung: a cancer and leukemia group B study. Cancer Treat Rep. 1981;65:767–774
  17. Osterlind K, Andersen PK. Prognostic factors in small cell lung cancer: multivariate model based on 778 patients treated with chemotherapy with or without irradiation. Cancer Res. 1986;46:4189–4194
  18. Cerney T, Blair V, Anderson H, et al. Pretreatment prognostic factors and scoring system in 407 small cell lung cancer patients. Int J Cancer. 1987;39:146–149
  19. Albain KS, Crowley JJ, Le Blanc M, et al. Determinants of improved outcome in small-cell lung cancer: an analysis of the 2,580-patient southwest oncology group data base. J Clin Oncol. 1990;8:1563–1574
  20. Byhardt RW, Hartz A, Libnoch JA, et al. Prognostic influence of TNM staging and LDH levels in small cell carcinoma of the lung (SCCL). Int J Radiat Oncol Biol Phys. 1986;12:771–777
  21. Vezzoni MA, Lucchini R, Giardini R, et al. Lactate dehydrogenase levels in cellular extracts of human malignant lymphomas. Tumori. 1983;69:279–282
  22. Ganz PA, Ma PY, Wang HJ, et al. Evaluation of three biochemical markers for serially monitoring the therapy of small cell lung cancer. J Clin Oncol. 1987;5:472–479
  23. Vincent MD, Ashley SE, Smith IA. Prognostic factors in small cell lung cancer: a simple prognostic index is better than conventional staging. Eur J Cancer Clin Oncol. 1987;23:1589–1599
  24. Hainsworth JD, Johnson DH, Farese RV. Limited stage small cell lung cancer: analysis of clinical prognostic factors. Southampt Med J. 1987;80:1518–1522
  25. Therasse P, Arbuck S, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst. 2000;92(3):205–216
  26. Osterlind K, Hirsch FR, Pedersen AG. Serum lactate dehydrogenase and bone marrow metastasis in small cell carcinoma of the lung. N Engl J Med. 1985;313:759
  27. Johnson DH, Greco AF. Serum lactate dehydrogenase and bone marrow metastasis in small cell carcinoma of the lung. N Engl J Med. 1985;313:759
  28. Sagman U, Feld R, Evans WK, et al. the prognostic significance of pretreatment serum lactate dehydrogenase in patients with small cell lung cancer. J Clin Oncol. 1991;9:954–961
  29. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481

PII: S0954-6111(10)00334-3

doi: 10.1016/j.rmed.2010.07.013

Respiratory Medicine
Volume 104, Issue 12 , Pages 1937-1942 , December 2010