Respiratory Medicine
Volume 104, Issue 12 , Pages 1943-1950 , December 2010

Elevated HDL cholesterol levels are associated with osteoporosis in lung transplant candidates with chronic obstructive pulmonary disease

  • Robert M. Reed

      Affiliations

    • Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
    • Corresponding Author InformationCorresponding author.
  • ,
  • Robert A. Wise

      Affiliations

    • Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
  • ,
  • Adrian S. Dobs

      Affiliations

    • Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, USA
  • ,
  • Noah Lechtzin

      Affiliations

    • Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
  • ,
  • Reda E. Girgis

      Affiliations

    • Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA

Received 24 April 2010 ,Accepted 9 August 2010.

References 

  1. Organ Procurement and Transplantation Network (OPTN) data, 12-31-2009 [accessed 31.12.09].
  2. Orens JB, Estenne M, Arcasoy S, Conte JV, Corris P, Egan JJ, et al. International guidelines for the selection of lung transplant candidates: 2006 update–a consensus report from the pulmonary scientific council of the international society for heart and lung transplantation. J Heart Lung Transplant. 2006;25(7):745–755
  3. Patel N, Criner GJ. Transplantation in chronic obstructive pulmonary disease. COPD. 2006;3(3):149–162
  4. Gross CR, Savik K, Bolman RM, Hertz MI. Long-term health status and quality of life outcomes of lung transplant recipients. Chest. 1995;108(6):1587–1593
  5. Jorgensen NR, Schwarz P. Osteoporosis in chronic obstructive pulmonary disease patients. Curr Opin Pulm Med. 2008;14(2):122–127
  6. Leech JA, Dulberg C, Kellie S, Pattee L, Gay J. Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis. 1990;141(1):68–71
  7. Schlaich C, Minne HW, Bruckner T, Wagner G, Gebest HJ, Grunze M, et al. Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int. 1998;8(3):261–267
  8. Ferrari SL, Nicod LP, Hamacher J, Spiliopoulos A, Slosman DO, Rochat T, et al. Osteoporosis in patients undergoing lung transplantation. Eur Respir J. 1996;9(11):2378–2382
  9. Trombetti A, Gerbase MW, Spiliopoulos A, Slosman DO, Nicod LP, Rizzoli R. Bone mineral density in lung-transplant recipients before and after graft: prevention of lumbar spine post-transplantation-accelerated bone loss by pamidronate. J Heart Lung Transplant. 2000;19(8):736–743
  10. Graat-Verboom L, Wouters EF, Smeenk FW, van den Borne BE, Lunde R, Spruit MA. Current status of research on osteoporosis in COPD: a systematic review. Eur Respir J. 2009;34(1):209–218
  11. Biskobing DM. COPD and osteoporosis. Chest. 2002;121(2):609–620
  12. Dam TT, Harrison S, Fink HA, Ramsdell J, Barrett-Connor E. Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma. Osteoporos Int. 2009;
  13. Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J, et al. Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int. 2004;74(2):136–142
  14. Buizert PJ, van Schoor NM, Lips P, Deeg DJ, Eekhoff EM. Lipid levels: a link between cardiovascular disease and osteoporosis?. J Bone Miner Res. 2009;24(6):1103–1109
  15. D’Amelio P, Di Bella S, Tamone C, Ravazzoli MG, Cristofaro MA, Di Stefano M, et al. HDL cholesterol and bone mineral density in normal-weight postmenopausal women: is there any possible association?. Panminerva Med. 2008;50(2):89–96
  16. Dennison EM, Syddall HE, Aihie SA, Martin HJ, Cooper C. Lipid profile, obesity and bone mineral density: the Hertfordshire cohort study. QJM. 2007;100(5):297–303
  17. Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J. 2002;49(2):211–217
  18. Seishima M, Mori A, Torizawa H, Muto Y. [Hyper-HDL-cholesterolemia in patients with chronic pulmonary insufficiency]. Rinsho Byori. 1988;36(3):318–322
  19. Tisi GM, Conrique A, Barrett-Connor E, Grundy SM. Increased high density lipoprotein cholesterol in obstructive pulmonary disease (predominant emphysematous type). Metabolism. 1981;30(4):340–346
  20. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9(8):1137–1141
  21. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res. 2003;18(11):1947–1954
  22. Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A. Case finding for the management of osteoporosis with FRAX–assessment and intervention thresholds for the UK. Osteoporos Int. 2008;19(10):1395–1408
  23. Goettsch WG, de Jong RB, Kramarz P, Herings RM. Developments of the incidence of osteoporosis in The Netherlands: a PHARMO study. Pharmacoepidemiol Drug Saf. 2007;16(2):166–172
  24. Maio V, Yuen E, Rabinowitz C, Louis D, Jimbo M, Donatini A, et al. Using pharmacy data to identify those with chronic conditions in Emilia Romagna, Italy. J Health Serv Res Policy. 2005;10(4):232–238
  25. Baim S, Binkley N, Bilezikian JP, Kendler DL, Hans DB, Lewiecki EM, et al. Official positions of the international society for clinical densitometry and executive summary of the 2007 ISCD position development conference. J Clin Densitom. 2008;11(1):75–91
  26. Adami S, Braga V, Guidi G, Gatti D, Gerardi D, Fracassi E. Chronic intravenous aminobisphosphonate therapy increases high-density lipoprotein cholesterol and decreases low-density lipoprotein cholesterol. J Bone Miner Res. 2000;15(3):599–604
  27. Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int. 2007;18(9):1197–1202
  28. Aris RM, Neuringer IP, Weiner MA, Egan TM, Ontjes D. Severe osteoporosis before and after lung transplantation. Chest. 1996;109(5):1176–1183
  29. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006;83(1):146–154
  30. Solomon DH, Avorn J, Canning CF, Wang PS. Lipid levels and bone mineral density. Am J Med. 2005;118(12):1414
  31. Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Playing with bone and fat. J Cell Biochem. 2006;98(2):251–266
  32. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113(6):846–855
  33. Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, et al. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res. 2004;19(5):830–840
  34. Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL. High-density lipoprotein regulates calcification of vascular cells. Circ Res. 2002;91(7):570–576
  35. Luegmayr E, Glantschnig H, Wesolowski GA, Gentile MA, Fisher JE, Rodan GA, et al. Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins. Cell Death Differ. 2004;11(Suppl. 1):S108–S118
  36. Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004;24(2):e6–e10
  37. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002;111(3):305–317
  38. Silver DL, Jiang XC, Tall AR. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. J Biol Chem. 1999;274(7):4140–4146
  39. Lundasen T, Liao W, Angelin B, Rudling M. Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice. J Biol Chem. 2003;278(44):43224–43228
  40. Rainwater DL, Comuzzie AG, VandeBerg JL, Mahaney MC, Blangero J. Serum leptin levels are independently correlated with two measures of HDL. Atherosclerosis. 1997;132(2):237–243
  41. Reid IR. Relationships between fat and bone. Osteoporos Int. 2008;19(5):595–606
  42. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999;140(4):1630–1638
  43. Hansel NN, Gao L, Rafaels NM, Mathias RA, Neptune ER, Tankersley C, et al. Leptin receptor polymorphisms and lung function decline in COPD. Eur Respir J. 2009;34(1):103–110
  44. Eker S, Ayaz L, Tamer L, Ulubas B. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Scand J Clin Lab Invest. 2009;
  45. Sood A. Obesity, adipokines and lung disease. J Appl Physiol. 2009;
  46. Maggi S, Siviero P, Gonnelli S, Schiraldi C, Malavolta N, Nuti R, et al. Osteoporosis risk in patients with chronic obstructive pulmonary disease: the EOLO study. J Clin Densitom. 2009;12(3):345–352
  47. Silverman SL, Lane NE. Glucocorticoid-induced osteoporosis. Curr Osteoporos Rep. 2009;7(1):23–26
  48. Choi HK, Seeger JD. Glucocorticoid use and serum lipid levels in US adults: the third national health and nutrition examination survey. Arthritis Rheum. 2005;53(4):528–535
  49. Praet JP, Peretz A, Rozenberg S, Famaey JP, Bourdoux P. Risk of osteoporosis in men with chronic bronchitis. Osteoporos Int. 1992;2(5):257–261
  50. Jiang XC, D’Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M. Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia. J Biol Chem. 1998;273(25):15714–15718
  51. Tin’kov AN, Aksenov VA. Effects of intermittent hypobaric hypoxia on blood lipid concentrations in male coronary heart disease patients. High Alt Med Biol. 2002;3(3):277–282
  52. Zahm AM, Bucaro MA, Srinivas V, Shapiro IM, Adams CS. Oxygen tension regulates preosteocyte maturation and mineralization. Bone. 2008;43(1):25–31
  53. Muzylak M, Price JS, Horton MA. Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat. Calcif Tissue Int. 2006;79(5):301–309
  54. Ferguson GT, Calverley PM, Anderson JA, Jenkins CR, Jones PW, Willits LR, et al. Prevalence and progression of osteoporosis in patients with COPD. Results from TORCH. Chest. 2009;
  55. Kalyani RR, Gavini S, Dobs AS. Male hypogonadism in systemic disease. Endocrinol Metab Clin North Am. 2007;36(2):333–348
  56. Laghi F, Antonescu-Turcu A, Collins E, Segal J, Tobin DE, Jubran A, et al. Hypogonadism in men with chronic obstructive pulmonary disease: prevalence and quality of life. Am J Respir Crit Care Med. 2005;171(7):728–733
  57. Karadag F, Ozcan H, Karul AB, Yilmaz M, Cildag O. Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease. Int J Clin Pract. 2009;63(2):275–281
  58. McEvoy CE, Ensrud KE, Bender E, Genant HK, Yu W, Griffith JM, et al. Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(3 Pt 1):704–709

PII: S0954-6111(10)00349-5

doi: 10.1016/j.rmed.2010.08.004

Respiratory Medicine
Volume 104, Issue 12 , Pages 1943-1950 , December 2010