Respiratory Medicine
Volume 104, Issue 12 , Pages 1929-1936 , December 2010

Behaviour and survival of high-grade neuroendocrine carcinomas of the lung

  • J.M. Naranjo Gómez

      Affiliations

    • Department of Thoracic Surgery, Hospital Universitario Marqués de Valdecilla, Servicio de Cirugía Torácica, Avda. de Valdecilla 25, 39008 Santander (Cantabria), Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34942202520; fax: +34942202520.
    • ,
  • J.J. Gómez Román

      Affiliations

    • Department of Pathology, Hospital Universitario Marqués de Valdecilla, Avda. de Valdecilla 25, 39008 Santander (Cantabria), Spain

Received 29 May 2009 ,Accepted 9 August 2010.

References 

  1. Arrigoni MG, Woolner LB, Bernatz PE. Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg. 1972;64:413–421
  2. Hammond ME, Sause WT. Large cell neuroendocrine tumors of the lung. Cancer. 1985;56:1624–1629
  3. Warren WH, Faber LP, Gould VE. Neuroendocrine neoplasms of the lung: a clinicopathologic update. J Thorac Cardiovasc Surg. 1989;98:321–332
  4. Travis WD, Linnoila RI, Tsokos MG. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, imunohistochemical, and flow cytometry study of 35 cases. Am J Surg Pathol. 1991;15:529–553
  5. World Health Organization . Histological typing of lung and pleural tumors. 3rd ed.. Germany: Springer; 1999;
  6. William D, Travis MD. The 2004 WHO classification of neuroendocrine lung tumors. In:  Travis WD,  Brambilla E,  Müller-Hermelink H,  Harris CC editor. Tumors of the lung, pleura, thymus and heart. Lyon, France: IARC Press; 2004;p. 59–63
  7. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Fujisawa T, Ohwada H. Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer. 2001;91:1992–2000
  8. Jiang SH, Kameya T, Shoji M, Dodashi Y, Shinada J, Yoshimura H. Large cell neuroendocrine carcinoma of the lung: a histologic and immunohisochemical study of 22 cases. Am J Surg Pathol. 1998;22:526–537
  9. Takei H, Asamura H, Maeshima A. Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg. 2002;124:285–292
  10. Asamura H, Kameya T, Matsuno Y. Neuroendocrine neoplasms of the lung: a prognostic.spectrum. J Clin Oncol. 2006;24:70–76
  11. Paci M, Cavazza A, Annessi V. Large cell neuroendocrine carcinoma of the lung: a 10-year.clinicopathologic retrospective study. Ann Thorac Surg. 2004;77:1163–1167
  12. Bataffarano RJ, Fernandez FG, Ritter J. Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;130:166–172
  13. Iyoda A, Hiroshima K, Toyozaki T. Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. Cancer. 2001;92:1108–1112
  14. Mazières J, Daste G, Molinier L. Large cell neuroendocrine carcinoma of the lung: pathological study and clinical outcome of 18 resected cases. Lung Cancer. 2002;37:287–292
  15. Dresler CM, Ritter JH, Patterson GA, Ross E, Baylei MS, Wick MR. Clinical-pathologic analysis of 40 patients with large cell neuroendocrine carcinoma of the lung. Ann Thorac Surg. 1997;63:180–185
  16. Fernández FG, Battafarano RJ. Large-cell neuroendocrine carcinoma of the lung: an aggressive neuroendocrine lung cancer. Semin Thorac Cardiovasc Surg. 2006;18:206–210
  17. Iyoda A, Hiroshima K, Moriya Y. Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma. J Thorac Cardiovasc Surg. 2006;132:312–315
  18. Zacharias J, Nicholson AG, Ladas GP, Goldstraw P. Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic nodal dissection. Ann Thorac Surg. 2003;75:348–352
  19. Mountain CF. Revisions in the international system for staging lung cancer. Chest. 1997;111:1710
  20. Travis WD, Rush W, Flieder DB, Falk R, Fleming MV, Gal AA. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol. 1998;22:934–944
  21. Travis WD, Gal AA, Colby TV, Klimstra DS, Falk R, Koss MN. Reproducibility of neuroendocrine lung tumors classification. Hum Pathol. 1998;29:272–279
  22. Marchevsky AM, Gal AA, Shah S. Morphometry confirms the presence of considerable nuclear size overlap between “small cells” and “large cells” in high grade pulmonary neuroendocrine neoplasms. Am J Clin Pathol. 2001;116:463–464
  23. Garcia-Yuste M, Matilla JM, Duke JL, Heras F, Cerezal LJ, Ramos G. Prognostic factors in neuroendocrine lung tumors: a Spanish multicentre study. Ann Thorac Surg. 2000;70:258–263
  24. Rusch VW, Klimstra DS, Venkatraman ES. Molecular markers help characterize neuroendocrine lung tumors. Ann Thorac Surg. 1996;62:798–810
  25. Kato H, Ichinose Y, Ohta M. Japan Lung Cancer Research Group on postsurgical adjuvant chemotherapy with uraciltegafur for adenocarcinoma of the lung. N Engl J Med. 2004;350:1713–1721
  26. The International Adjuvant Lung Cancer Trial Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med. 2004;350:351–360
  27. Wilton T, Livingstone R, Johnson DF, National Cancer Institute of Canada , Clinical Trials Group , National Cancer Institute of the United States Intergroup JBR , et al. Vinorelbine plus cisplatine vs. observation in resected non- small-cell lung cancer. N Engl J Med. 2005;352:2589–2597
  28. Stuschke M, Pottgen C. Prophylactic cranial irradiation as a component of intensified initial treatment of locally advanced non-small cell lung cancer. Lung Cancer. 2003;42:S53–S56
  29. Auperin A, Arriaga R, Pignon JP. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. N Engl J Med. 1999;341:476–484

PII: S0954-6111(10)00352-5

doi: 10.1016/j.rmed.2010.08.007

Respiratory Medicine
Volume 104, Issue 12 , Pages 1929-1936 , December 2010

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