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General article| Volume 56, ISSUE 3, P131-138, July 1962

Toxic psychosis due to isoniazid

DOI:https://doi.org/10.1016/S0007-0971(62)80045-X
Toxic psychosis due to isoniazid
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      Summary

      • 1.
        Three cases of psychosis complicating isoniazid therapy are reported and the literature is reviewed.
      • 2.
        This complication is probably more common when the dose of isoniazid is high, but has been recorded on low dosage and after treatment periods of two days to ten months.
      • 3.
        There is usually a prodromal period of a few days when mental and muscular irritability, tremor and twitching are present.
      • 4.
        The psychosis has no specific pattern, but confusion, mania, hallucinations and paranoid delusions are all common.
      • 5.
        Probable precipitating factors are renal and hepatic disease, and PAS sensitisation. Negroid patients may be unusually susceptible.
      • 6.
        Recovery is usual if the drug is withdrawn, but may take several months. Approximately a third of the 38 patients had some residual symptoms at time of report.
      • 7.
        Treatment consists of withdrawing the drug. The efficacy of multivitamin therapy is still uncertain.
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      Article info

      Publication history

      Received: April 25, 1962

      Identification

      DOI: https://doi.org/10.1016/S0007-0971(62)80045-X

      Copyright

      © 1962 Published by Elsevier Inc.

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