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Abstract
Inhaled β2-agonists have been subject to restrictions in relationship to sports due to fear of possible improvement in endurance performance. According to the international doping regulations only inhaled salbutamol, terbutaline and salmeterol are allowed for use in sports. Formoterol is a recently introduced rapid onset-long-acting inhaled β2-agonist.
The main aim of the present randomized, double-blind placebo-controlled study was to investigate possible improvement in endurance performance of inhaled formoterol in 24 healthy well-trained competitive male athletes, 21–29 years old.
Lung function (flow–volume loops) was measured before, 15 min after each inhaled study drug and before and repeatedly after exercise. On day 1, maximum oxygen uptake (VO2max), peak ventilation (VEpeak) and running time till exhaustion were measured and used to determine the exercise load on days 2 and 3. On days 2 and 3 the subjects inhaled the study drugs, rested for 1 h, then exercised, and VO2max, VEpeakand running time until exhaustion were determined.
Inhaled formoterol did not improve any parameter of endurance performance. On the other hand a statistically significant, although not clinically significant (0·05 ml−1min kg−1), change was found in estimated difference of VO2maxbetween formoterol and placebo in favour of placebo. Lung function increased significantly after inhaled formoterol, and after exercise also for placebo, but without differences between the β2-agonist and placebo after exercise.
In conclusion, inhaled formoterol did not improve endurance performance compared to placebo.
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References
References
- Exercise-induced asthma in children.Eur Respir J. 1993; 6: 614-616
- Prevention of exercise induced asthma by inhaled salmeterol xinafoate.Arch Dis Child. 1992; 67: 1014-1017
- Inhaled formoterol in the prevention of exercise-induced bronchoconstriction in asthmatic children.Am J Respir Crit Care Med. 1994; 149: 935-939
- Self-reported asthma and exercise-induced asthma symptoms in high-level competetive cross-country skiers.Scand J Med Sci Sports. 1994; 4: 128-133
- Effect of clenbuterol on athletic performance.Ann Pharmacother. 1995; 29: 75-77
- The effect of inhaled salbutamol and salmeterol on lung function and endurance performance in healthy well-trained athletes.Scand J Med Sci Sports. 1997; 7: 160-165
- Is salmeterol ergogenic?.Clin J Sport Med. 1996; 6: 220-225
- Does single dose salmeterol affect exercise capacity in asthmatic men?.Eur Respir J. 1994; 7: 1978-1984
- eds.Textbook of Work Physiology. McGraw-Hill, New York1986
- High prevalence of asthma in cross country skiers.BMJ. 1993; 307: 1326-1329
- Exercise-induced asthma in figure skaters.Chest. 1996; 109: 312-315
- The incidence of exercise-induced bronchospasm in competitive figure skaters.J Asthma. 1996; 33: 67-71
- Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen.Br J Sports Med. 1998; 32: 125-129
- The effect of inhaled salbutamol and salmeterol on lung function and endurance performance in healthy well-trained athletes.Scand J Med Sci Sports. 1997; 7: 160-165
- Overnight protection by inhaled salmeterol on exercise-induced asthma in children.Eur Respir J. 1995; 8: 1852-1855
- Salmeterol versus formoterol in patients with moderately severe asthma: onset and duration of action.Eur Respir J. 1996; 9: 1684-1688
- Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients.Thorax. 1995; 50: 497-504
- Rapid onset of tolerance to the bronchoprotective effect of salmeterol.Chest. 1995; 108: 1235-1239
Article info
Publication history
Accepted:
March 15,
2001
Received:
March 15,
2001
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© 2001 Harcourt Publishers Ltd. Published by Elsevier Inc.
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