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Topical Review| Volume 95, ISSUE 7, P539-547, July 2001

Measurement and treatment of dyspnoea

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      References

      References

        • Lacasse Y
        • Wong E
        • Guyatt GH
        • Cook DJ
        • Goldstein RS
        Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease.
        Lancet. 1996; 348: 1115-1119
      1. Chest. 1997; 112: 1363-1396
        • Casaburi R
        • Patessio A
        • Loli F
        • Zanaboni S
        • Donner CF
        • Wasserman K
        Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease.
        Am Rev Respir Dis. 1991; 143: 9-18
      2. Am J Respir Crit Care Med. 1999; 159: 321-340
        • Manning HI
        • Schwartzstein RM
        Pathophysiology of dyspnoea.
        New Eng J Med. 1995; 333: 1353-1547
        • Mahler DA
        • Harver A
        • Lentine T
        Descriptors of breathlessness in cardiorespiratory diseases.
        Am J Respir Crit Care Med. 1996; 154: 1357-1363
        • Simon PM
        • Schwartzstein RM
        • Weiss JW
        Distinguishable types of dyspnoea in patients with shortness of breath.
        Am Rev Respir Dis. 1990; 142: 1009-1014
        • Mahler DA
        Dyspnoea.
        in: Fishman AP Pulmonary Rehabilitation. Marcel Dekker, New York1996: 97-116
        • O'Donnell DE
        Breathlessness in patients with chronic airflow limitation.
        Chest. 1994; 106: 904-912
        • Gandevia SC
        Neural mechanisms underlying the sensation of breathlessness: kinesthetic parallels between respiratory and limb muscles.
        Aus N Z J Med. 1988; 18: 83-91
        • Gottfried SB
        • Altose MD
        • Kelsen SG
        Perception of changes in airflow resistance in obstructive pulmonary disorders.
        Am Rev Respir Dis. 1981; 124: 566-570
        • Killian KJ
        • Mahutte CK
        • Campbell E JM
        Magnitude scaling of externally added loads to breathing.
        Am Rev Respir Dis. 1981; 123: 12-15
        • Fletcher CM
        • Elmes PC
        • Wood CH
        The significance of the respiratory symptoms and the diagnosis of chronic bronchitis in a work population.
        Br Med J. 1959; 2: 257-266
      3. Committee on Research into Chronic Bronchitis. Instructions for Use of the Questionnaire on Respiratory Symptoms. W.J. Holman, Devon1966
        • Huskisson EC
        Measurement of pain.
        Lancet. 1974; 2: 1127-1131
        • Aitken R CB
        Measurement of feeling using visual analog scales.
        Proc Roy Soc Med. 1969; 62: 989-993
        • Mahler DA
        The measurements of dyspnoea contents, interobserver agreement, and physiologic correlates of two new clinical indexes.
        Chest. 1984; 85: 751-758
        • Mahler D
        • Guyatt GH
        • Jones PW
        Clinical measurement of dyspnoea.
        in: Mahler D Dyspnoea. Marcel Dekker Publishers, New York1998: 149-198
        • Ferrari K
        • Goti P
        • Misuri G
        Chronic exertional dyspnoea and respiratory muscle function in patients with chronic obstructive pulmonary disease.
        Lung. 1997; 175: 311-319
        • Eakin EG
        • Sassi-Dambron DE
        • Ries AL
        • Kaplan RM
        Validation of the UCSD shortness of breath questionnaire.
        Int J Behav Med. 1995; 2: 118-134
        • Borg G AV
        Psychophysical bases of perceived exertion.
        Med Sci Sports Exerc. 1982; 14: 377-381
        • Mejia R
        • Ward J
        • Lentine T
        • Mahler DA
        Target dyspnoea ratings predict expected oxygen consumption as well as target heart rate values.
        Am J Respir Crit Care Med. 1999; 159: 1483-1489
        • Killian KJ
        • Le Blanc P
        • Martin DH
        Exercise capacity and ventilatory, circulatory and symptom limitation in patients with chronic airflow limitation.
        Am Rev Respir Dis. 1992; 146: 935-940
        • Marciniuk DD
        • Watts RE
        • Gallagher CG
        Reproducibility of incremental maximal cycle ergometer testing in patients with restrictive lung disease.
        Thorax. 1993; 48: 894-898
        • O'Donnel DE
        • Webb KA
        Breathlessness in patients with severe airflow limitation.
        Chest. 1992; 102: 825-830
        • Guyatt GH
        • Berman LB
        • Townsend M
        • Pugsley SO
        • Chanbers LW
        A measure of quality of life for clinical trials in chronic lung disease.
        Thorax. 1987; 42: 773-778
        • Mahler DA
        • Tomlinson D
        • Olmstead EM
        • Tosteson A NA
        • O'Connor GT
        Changes in dyspnoea, health status, and lung function in chronic airway disease.
        Am J Respir Crit Care Med. 1995; 151: 61-65
        • Manning HL
        • Mahler DA
        • Harver A
        Dyspnoea in the-Elderly.
        in: Mahler D. Pulmonary Disease in the Elderly Patient. Marcel Dekker, New York1990: 81-105
        • Foglio K
        • Carone M
        • Pagani M
        Physiological and symptom determinants of exercise performance in patients with chronic airway obstruction (CAO).
        Respir Med. 2000; 94: 256-263
        • Hajiro T
        • Nishimura K
        • Tsukino M
        Analysis of clinical methods used to evaluate dyspnoea in patients with chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 1998; 158: 1185-1189
        • Jones PW
        • Quirk FH
        • Baveystock CM
        • Littlejohn T
        A self-complete measure of health status for chronic airflow limitation.
        Am Rev Respir Dis. 1992; 145: 1321-1327
        • Grant S
        • Aitchison T
        • Henderson E
        A comparison of the reproducibility and the sensitivity to change of visual analogue scales, Borg scales, and Likert scales in normal subjects during submaximal exercise.
        Chest. 1999; 116: 1208-1217
        • Swinburn CR
        • Wakefield IM
        • Jones PW
        Relationship between ventilation and breathlessness during exercise in chronic obstructive airway disease is not altered by prevention of hypoxemia.
        Clin Sci. 1984; 67: 146-149
        • Stark RD
        • Gambles SA
        • Lewis JA
        Methods to assess breathlessness in healthy subjects: a critical evaluation and application to analyse the acute effects of diazepam and promethazine on breathlessness induced by exercise or by exposure to raised levels of carbon dioxide.
        Clin Sci. 1981; 61: 429-439
        • O'Donnell DE
        • Bain DI
        • Webb KA
        Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation.
        Am J Respir Crit Care Med. 1997; 155: 530-535
        • Bye P TP
        • Esau SA
        • Levy RO
        Ventilatory muscle function during exercise in air and oxygen in patients with chronic air-flow limitation.
        Am Rev Respir Dis. 1985; 132: 236-240
        • Criner GJ
        • Celli BR
        Ventilatory muscle recruitment in exercise with O2in obstructed patients with mild hypoxemia.
        J Appl Physiol. 1987; 63: 195-200
        • Breslin E
        • Garrotte B
        • Kohlman-Carrieri V
        • Celli B
        Correlations between dyspnea, diaphragm and sternomastoid recruitment during inspiratory resistance breathing in normal subjects.
        Chest. 1990; 98: 298-302
        • Ward ME
        • Eidelman D
        • Stubbing D
        • Bellemare F
        • Macklem PT
        Respiratory sensation and pattern of respiratory muscle activation during diaphragm fatigue.
        J Appl Physiol. 1988; 65: 2181-2189
        • Marin JM
        • Montes de Oca M
        • Rassulo J
        • Celli BR
        Ventilatory drive at rest and perception of exertional dyspnoea in severe COPD.
        Chest. 1999; 115: 1293-1300
        • Montes de Oca M
        • Rassulo J
        • Celli BR
        Respiratory muscle and cardiopulmonary function during exercise in very severe COPD.
        Am J Respir Crit Care Med. 1996; 154: 1284-1289
        • Swinburn CR
        • Mould H
        • Stone TN
        • Corris PA
        • Gibson G
        Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease.
        Am Rev Respir Dis. 1991; 143: 913-918
        • Lane R
        • Cockcroft A
        • Adams L
        • Guz A
        Arterial oxygen saturation and breathlessness in patients with chronic obstructive airway disease.
        Clin Sci. 1987; 72: 693-698
        • Liss HP
        • Grant B IB
        The effect of nasal flow on breathlessness in patients with chronic obstructive pulmonary disease.
        Am Rev Respir Dis. 1988; 137: 126-133
        • Altose MD
        Respiratory muscles and dyspnoea.
        Semin Respir Med. 1992; 13: 1-6
        • Farncombe M
        • Chater S
        • Gillin A
        Clinical application of nebulized opioids for treatment of dyspnoea in patients with malignant disease.
        Care Cancer. 1994; 2: 184-187
        • Woodcock AA
        • Gross ER
        • Geddes DM
        Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers.
        Br Med J. 1981; 283: 343-346
        • Man G CW
        • Hsu K
        • Sproule BJ
        Effect of alprazolam on exercise and dyspnoea in patients with chronic obstructive pulmonary disease.
        Chest. 1986; 90: 832-836
        • Mitchell- Heggs P
        • Murphy H PK
        Diazepam in the treatment of dyspnoea in the ‘pink puffer’ syndrome.
        Quart J Med. 1980; 49: 9-20
        • Singh N IP
        • Despars JA
        • Stansbury DW
        • Avalos K
        • Light RW
        Effects of buspirone on anxiety levels and exercise tolerance in patients with chronic airflow obstruction and mild anxiety.
        Chest. 1994; 103: 800-804
        • Stark RD
        • O'Neill PA
        • Russel N JW
        • Heapy CG
        • Stretton TB
        Effects of small particle aerosols of local anaesthetic on dyspnoea in patients with respiratory disease.
        Clin Sci. 1985; 69: 29-36
        • Winning A l
        • Hamilton RD
        • Guz A
        Ventilation and breathlessness on maximal exercise in patients with interstitial lung disease after local anesthetic aerosol inhalation.
        Clin Sci. 1988; 74: 275-281
        • Guz A
        • Noble N IM
        • Eisele IH
        • Trenchard D
        Experimental results of vagal blockade in cardiopulmonary disease.
        in: Porter R Breathing: Hering-Breuer Centenary Symposium. Churchill, London1970: 315-329
        • Kimoff RI
        • Cheong TT
        • Cosio MG
        • Querraty A
        • Levy RD
        Pulmonary denervation effects on dyspnoea and ventilatory pattern during exercise.
        Am Rev Respi Dis. 1990; 142: 1034-1040
        • Bradley GW
        • Hale T
        • Pimble J
        • Rowslandson R
        • Noble M IM
        Effect of Vagotomy on the breathing pattern and exercise ability in emphysematous patients.
        Clin Sci. 1982; 62: 311-319
        • Taguchi O
        • Kikuchi Y
        • Hida W
        Effects of bronchoconstriction and external resistive loading on the sensation of dyspnoea.
        J Appl Physiol. 1991; 71: 2183-2190
        • O'Neil PA
        • Stetton TB
        • Stark RD
        • Ellis SH
        The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung.
        Br J Dis Chest. 1986; 80: 72-79
        • Taguchi O
        • Kikuchi Y
        • Hida W
        Prostaglandin E2 inhalation increases the sensation of dyspnea during exercise.
        Am-Rev Respir Dis. 1992; 145: 1346-1349
        • O'Donnell DE
        • Webb KA
        Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation.
        Am Rev Respir Dis. 1993; 148: 1351-1357
        • O'Donnell DE
        • Bertley JC
        • Chau LL
        • Webb KA
        Qualitative aspects of exertional breathlessness in chronic airflow limitation. pathophysiologic mechanisms.
        Am J Respir Crit Care Med. 1997; 155: 109-115
        • Belman MI
        • Botnick WC
        • Shin IW
        Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 1996; 153: 967-975
        • Hay JG
        • Stone P
        • Carter S
        Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructed pulmonary disease.
        Eur Respir J. 1992; 5: 659-664
        • O'Donnell DE
        • Lam M
        • Webb KA
        Spirometric correlates of improvement in excercise performance after anticholinergic therapy in chronic obstructive pulmonary disease.
        Am J Crit Care Med. 1999; 160: 542-549
        • Chrystyn H
        • Mulley BA
        • Peake MD
        Dose response relation to oral theophylline in severe chronic obstructive airways disease.
        Br Med J. 1988; 297: 1506-1510
        • Murciano D
        • Auclair MH
        • Pariente R
        • Aubier M
        A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary disease.
        N Engl J Med. 1989; 320: 1521-1525
        • Murciano D
        • Aubier M
        • Lecocguic Y
        • Pariente R
        Effect of theophylline on diaphragm strength and fatigue in patients with chronic obstructive pulmonary disease.
        N Eng J Med. 1984; 311: 349-353
        • Trayner EM
        • Celli BR
        Strategies in the treatment of dyspnoea: disease specific.
        in: Mahler DA Dyspnoea. Marcel Dekker, 1998: 261-285
        • Russos C
        • Macklem PT
        The respiratory muscles.
        N Engl J Med. 1982; 307: 786-797
        • Arora NS
        • Rochester DF
        Respiratory muscle strength and maximal voluntary ventilation in undernourished patients.
        Am Rev Respir Dis. 1982; 126: 5-8
        • Thurlbeck WM
        Diaphragm and body weight in emphysema.
        Thorax. 1978; 33: 483-487
        • Arora NS
        • Rochester DF
        Effect of chronic airflow limitation on sternomastoid muscle thickness.
        Chest. 1984; 85: 585-595
        • Efthimiou J
        • Fleming J
        • Gomes C
        • Spiro SG
        The effect of supplemental oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease.
        Am Rev Respir Dis. 1988; 137: 1075-1082
        • Schols A MW
        • Soeters J
        • Mostert PB
        • Pluymers RJ
        • Wouters E FM
        Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 1995; 152: 1268-1274
        • Driver AG
        • MacAuley M
        • Smith JL
        Nutritional assessment of patients with chronic obstructive pulmonary disease and acute respiratory failure.
        Chest. 1982; 82: 568-571
        • Goldstein SA
        • Thomashow BM
        • Kvetan V
        Nitrogen and energy relationships in malnourished patients with emphysema.
        Am Rev Respir Dis. 1988; 138: 636-644
        • Whittaker S
        • Ryan CF
        • Buckely PA
        • Road JD
        The effects of refeeding on peripheral and respiratory muscle function in malnourished chronic obstructive pulmonary disease patients.
        Am Rev Respir Dis. 1990; 142: 283-288
        • Rogers RM
        • Donahoe M
        • Costantino I
        Physiologic effects of oral supplemental feeding in malnourished patients with chronic obstructive pulmonary disease.
        Am Rev Respir Dis. 1992; 146: 1511-1517
        • Goldstein SA
        • Thomashow B
        • Askanazi J
        Functional changes during nutritional repletion in patients with lung disease.
        Clin Chest Med. 1986; 7: 141-149
        • Higgs C MB
        • Laszlo G
        Influence of treatment with beclomethasone, cromoglycate and theophylline on perception of bronchoconstriction in patients with bronchial asthma.
        Clin Sci. 1996; 90: 227-234
        • In't Veen J CCM
        • Smits HH
        • Ravensberg A JJ
        Impaired perception of dyspnoea in patients with severe asthma.
        Am J Respir Crit Care Med. 1998; 158: 1134-1141
        • Restrick LJ
        • Paul EA
        • Braid GM
        Assessment and follow up of patients prescribed long term oxygen therapy.
        Thorax. 1993; 48: 708-713
        • Gosselink R
        • Troosters T
        • Decramer M
        Exercise training in COPD patients: the basic questions.
        Eur Respir J. 1997; 10: 2884-2891
        • Maltais F
        • LeBlanc P
        • Jobin J
        Intensity of training and physiologic adaptation in patients with chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 1997; 155: 555-561
        • Criner GJ
        • Cordova FC
        • Furukawa S
        Prospective randomized trial comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 1999; 160: 2018-2027
        • Smith L
        • Cook D
        • Guyatt G
        • Madhavan J
        • Oxman A
        Respiratory muscle training in chronic airflow limitation: a meta-analysis.
        Am Rev Respir Dis. 1992; 145: 533-539
        • Garrod R
        • Paul EA
        • Wedzicha JA
        Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia.
        Thorax. 2000; 55: 539-543
        • Ambrosino N
        Exercise and noninvasive ventilatory support.
        Monaldi Arch Chest Dis. 2000; 55: 242-246
        • Garrod R
        • Mikelsons C
        • Paul EA
        • Wedzicha JA
        Randomized controlled trial of domiciliary noninvasive positive pressure ventilation and physicial training in severe chronic obstructive pulmonary disease.
        Am J Respir Crit Care Med. 2000; 162: 1335-1341
        • Martinez FJ
        • Montes de Oca M
        • Whyte RI
        Lung-volume reduction improves dyspnoea, dynamic hyperinflation and respiratory muscle function.
        Am J Respir Crit Care Med. 1997; 155: 1984-1990
        • Marchand E
        • De Leyn P
        • Gayan-Ramirez G
        Lung volume reduction surgery does not improve diaphragmatic contractile properties or atrophy in hamsters with elastase-induced emphysema.
        Am J Respir Crit Care Med. 2000; 162: 1052-1057