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Abstract
Exposure to mushroom spores may cause many respiratory allergic diseases, however, there has been no serial study in a mushroom factory to address this problem. The aim of this study was to investigate the serial changes in respiratory allergy and the incidence of hypersensitivity pneumonitis (HP) in mushroom workers. A 3-year follow-up study, beginning in June 1996, was conducted in a newly operating mushroom factory in which one kind of mushroom is produced: Hypsizigus marmoreus (Bunashimeji). Allergic symptoms, chest roentgenogram, serum precipitins to the spores and soluble adhesion molecules in sera were evaluated once a year in 60 workers and 20 controls. Three out of the 60 subjects were diagnosed as having HP caused by inhalation of the mushroom spore and they were therefore excluded from this study, and the 57 non-HP subjects were evaluated. In this study 24 workers quit because of intolerable cough, runny nose, wheezing, sputum, fever elevation and/or shortness of breath at their place of work. During each year of this study as many as 70–80% of employees suffered some of the above symptoms, cough being the most frequent, and positive rate of serum precipitins to the spore revealed 30% in 1996, 93% in 1997 and 94% in 1998. From the June 1996 examination until the following May, serum soluble intercellular adhesion molecule-1 levels of the 15 workers who quit during that period were significantly higher than those in the 42 workers still employed in 1997 (P<0·05). Workers in Bunashimeji mushroom factories might be at critical risk of developing respiratory allergy. In our 3-year study, over 90% workers were sensitized to the spore, 40% quit because of the symptoms and 5% developed HP. It was suggested that workers should be counselled about the risk of mushroom allergy and precautionary measures should be taken to prevent its occurrence.
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References
REFERENCES
- Hypersensitivity pneumonitis due to Mushroom (Pholiota nameko) spores.Chest. 1989; 95: 1149-1151
- Mushroom worker's lung due to inhalation of spores of the Cortinus Shiitake.Jpn J Chest Dis. 1981; 11: 934-938
- Respiratory and immunological reactions among Shiitake (Lentinus edodes) mushroom workers.Clin Exp Allergy. 1990; 20: 13-19
- A new form of mushroom workers' lung.Rev Mal Resp. 1991; 8: 308-310
- Hypersensitivity pneumonitis induced shiitake mushroom spores.Int Med. 1992; 31: 1204-1206
- Hypersensitivity pneumnitis induced by inhalation of mushroom (Pholiota nameko) spores.Intern Med. 1994; 33: 683-685
- Hypersensitivity pneumonitis induced by spores of Pholiota Nameko.Int Med. 1996; 35: 301-304
- Mushroom worker's lung by spores of Hypsizigus marmoreus (Bunashimeji); elevated serum surfacant protein D.Chest. 2000; 118: 1506-1509
- Outbreak of hypersensitivity pneumonitis among mushroom farm workers.Am J Industrial Med. 1992; 22: 859-872
- Circulating ICAM-1 isoform: diagnostic prospects for inflammatory and immune disorders.Lancet. 1991; 338: 83-84
- Detection of a circulating form of vascular cell adhesion molecule-1: raised levels in rheumatoid arthritis and systemic lupus erythematyosus.Clin Exp Immunol. 1993; 92: 412-418
- Intercellular adhesion molecles-1 (ICAM-1) in the pathogenesis of asthma.Science. 1990; 247: 456-459
- Antigen-antibody reactions in gels: types of reactions in coordinated systems of diffusion.Acta Pathol Microbiol Scand. 1953; 32: 231-234
- Detection of circulating intercellular adhesion molecule-1 antigen in malignant disease.Clin Exp Immunol. 1991; 85: 3-8
- Probleme der Begutachtung bei exogenen- allergischen alveolitiden.Atemw Lung Enkrankrkh. 1983; 12: 448-453
- A critical review of the role of precipitins in hypersensitivity pneumonitis.Eur J Respir Dis. 1981; 62: 332-343
- The value of precipitating antibodies in screening for hypersensitivity pneumonitis.Am Rev Respir Dis. 1976; 62: 451-455
- Mushroom allergy.Allergy. 1988; 43: 1-10
- Provocation tests in extrinsic allergic alveolitis in mushroom workers.Neth J Med. 1991; 38: 59-64
- Ingestive and inhalative allergy to the mushroom Boletus edulis.Allergy. 1997; 52: 747-751
- Prevalence of basidiospore allergy in the Pacific Northwest.J Allergy Clin Immunol. 1986; 82: 1076-1080
- IL-4 acts synergistically with IL-1b to promote lymphocyte adhesion adhesion to microvascular endotherium by induced of vascular cell adhesion molecule-1.J Immunol. 1990; 145: 2886-2895
- Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production.Blood. 1994; 84: 1913-1921
- IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1.J Immunol. 1992; 148: 1086-1092
- Role of vascular cell adhesion molecule 1/ very late activation antigen 4 and intercellular adhesion molecule 1/ lymophcyte function- associated antigen—interaction in antigen-induced eosinophil and T cell recruitment into the tissue.J Exp Med. 1994; 179: 1145-1154
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Publication history
Accepted:
June 15,
2001
Received:
September 15,
2000
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© 2001 Harcourt Publishers Ltd. Published by Elsevier Inc.
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