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One-hundred and ninety-nine patients with peripheral lymph node tuberculosis were
randomized to treatment with either E2H9R9, Z2H9R9 or Z2H6R6 regimens (E, ethambutol;
H, isoniazid; R, rifampicin; Z, pyrazinamide; numbers denote duration of therapy in
months). One-hundred and thirty-three patients were diagnosed by aspiration/biopsy
leaving residual nodes, 44 were diagnosed after excision of the palpable nodes and
22 were diagnosed on clinical grounds supported by a strongly positive tuberculin
test. Treatment was completed as planned by 157 patients. Eight patients required
aspirations after commencing chemotherapy, seven on ethambutol and one on pyrazinamide
(P = 0005). There was no statistically significant difference between the regimens in
speed of resolution of nodes, or in the percentage with residual nodes at the end
of treatment, or inthe numbers developing fluctuation or sinuses. Follow-up to 30
months from commencement of treatment continues in order to establish relapse rates
for the regimens.
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References
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Article info
Publication history
Accepted:
July 23,
1991
Received:
June 5,
1991
Footnotes
*This study was organized by a subcommittee comprizing: Dr I. A. Campbell (Chairman), Dr L. P. Ormerod
(Coordinator and compiler of report), Dr J. A. R. Friend, Dr P. A. Jenkins and Dr R.J. PrescottIdentification
Copyright
© 1992 Baillière Tindall All rights reserved. Published by Elsevier Inc.
