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Changes in spirometry during consecutive admissions for treatment of pulmonary infective
exacerbations were studied in 45 patients (24 males, 21 females) with cystic fibrosis
(CF) who had required five or more such admissions. Over the overall study period
there was a mean (sd) decline in FEV, of −112.1 (188.0) ml yr−1 (P < 0001) and in FVC of − 47.9 (82.4) ml yr−1 (P < 0001). FEV1 and FVC increased during each admission with treatment; however, the magnitude of
this change became less over consecutive admissions by a mean value of −33.3 ml (45.0)
(P<0.001) for FEV1, and −260 (72.2) ml (P<005) for FVC. In the majority of patients that died or underwent transplantation,
FEV, at the time of the last admission did not rise above 800 ml despite full treatment.
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Article info
Publication history
Accepted:
August 28,
1991
Received:
February 6,
1991
Identification
Copyright
© 1992 Baillière Tindall All rights reserved. Published by Elsevier Inc.
