Highlights
- •ST level/patterns in COPD are worse than in bronchiectasis & severe asthma.
- •ST volume in severe asthma, bronchiectasis and non-respiratory controls are similar.
- •Lower volume/better ST accrual patterns are associated with key clinical outcomes.
- •The strength of the association between ST and clinical outcomes differs by disease.
- •ST volume & accrual patterns are important, different, and yet complementary metrics.
Abstract
Sedentary time (ST) and light-intensity physical activity (LIPA) are movement behaviours
associated with important health outcomes, but are not widely explored in respiratory
diseases. We aimed to describe their volume and/or accumulation patterns in moderate-severe
COPD, bronchiectasis and severe asthma using the accurate postural-based accelerometer
activPAL, contrasting these values with a non-respiratory population. We also sought
to test the cross-sectional associations of these behaviours with disease characteristics
by diagnostic group, and as a combined label-free disease group.
Results
Adults with COPD (n = 64), bronchiectasis (n = 61), severe asthma (n = 27), and controls
(n = 61) underwent cross-sectional measurements of volume and/or accumulation patterns
of ST and LIPA. The prevalence and characteristics, and associations with exercise
capacity, health-status, airflow-limitation, dyspnoea, systemic inflammation and exacerbations
were analysed.
ST volumes in COPD were higher than that of bronchiectasis and severe asthma. Values
in bronchiectasis and severe asthma were similar to each other and controls (≈8.9 h/day).
Their accumulation patterns were also significantly better than in COPD, but similar
if not worse compared to controls. LIPA volumes in bronchiectasis and severe asthma
were also higher than those of COPD (p < 0.05) and controls. In bronchiectasis and COPD, lower levels/better patterns of
ST accumulation, as well as higher LIPA volume were associated with better clinical
characteristics. These associations may be mediated by airflow limitation.
Conclusions
The discordance between engagement in ST volume versus ST patterns highlights the
importance of accounting for both these different yet complementary metrics. ST and
LIPA are low-intensity activities associated with important clinical characteristics
in people with chronic respiratory diseases.
Trial registration
Not applicable.
Abbreviations:
ST (sedentary time), LIPA (light-intensity physical activity), COPD (chronic obstructive pulmonary disease), MET (metabolic equivalent of task), MVPA (moderate to vigorous physical activity), FEV1 (forced expiratory volume in 1-s), FVC (forced vital capacity), 6MWT (6-min walk test), mMRC (modified Medical Research Dyspnoea Scale), SGRQ (St. George Respiratory Questionnaire), MCID (minimal clinically important difference), Hs-CRP (high sensitivity C- reactive protein), BMI (body mass index), CI (confidence interval), Coeff (coefficients), OR (odds ratio)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 23, 2021
Accepted:
March 8,
2021
Received in revised form:
March 7,
2021
Received:
February 3,
2021
Identification
Copyright
© 2021 Elsevier Ltd. All rights reserved.
