Highlights
- •It is an international study with large cohort of patients with sarcoidosis.
- •Organ involvement and treatment differed according to race, sex, and age.
- •Black and female individuals were more likely to have multiple organ involvement.
- •Age at diagnosis<45, Black patients and multiple organ involvement were independent predictors of treatment.
Abstract
Objective
To study how demographic differences impact disease manifestation of sarcoidosis using
the WASOG tool in a large multicentric study.
Methods
Clinical data regarding 1445 patients with sarcoidosis from 14 clinical sites in 10
countries were prospectively reviewed from Feb 1, 2020 to Sep 30, 2020. Organ involvement
was evaluated for the whole group and for subgroups differentiated by sex, race, and
age.
Results
The median age of the patients at diagnosis was 46 years old; 60.8% of the patients
were female. The most commonly involved organ was lung (96%), followed by skin (24%)
and eye (22%). Black patients had more multiple organ involvement than White patients
(OR = 3.227, 95% CI: 2.243–4.643) and females had more multiple organ involvement
than males (OR = 1.238, 95% CI: 1.083–1.415). Black patients had more frequent involvement
of neurologic, skin, eye, extra thoracic lymph node, liver and spleen than White and
Asian patients. Women were more likely to have eye (OR = 1.522, 95%CI: 1.259–1.838)
or skin involvement (OR = 1.369, 95%CI: 1.152–1.628). Men were more likely to have
cardiac involvement (OR = 1.326, 95%CI: 1.096–1.605). A total of 262 (18.1%) patients
did not receive systemic treatment for sarcoidosis. Therapy was more common in Black
patients than in other races.
Conclusion
The initial presentation and treatment of sarcoidosis was related to sex, race, and
age. Black and female individuals are found to have multiple organ involvement more
frequently. Age at diagnosis<45, Black patients and multiple organ involvement were
independent predictors of treatment.
Keywords
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Article info
Publication history
Published online: August 08, 2021
Accepted:
August 4,
2021
Received in revised form:
July 31,
2021
Received:
June 7,
2021
Identification
Copyright
© 2021 Published by Elsevier Ltd.
