Short communication| Volume 188, 106600, November 2021

Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients

Published:September 07, 2021DOI:


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        LCQ and VAS are two tools to assess cough related quality of life.
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        LCQ and VAS in sarcoidosis are influenced by FeV1 and BMI
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        Serological parameters are not associated with LCQ score


      Sarcoidosis is a granulomatous disease that mainly manifests within the lungs and may thereby impair lung function. Beyond and independently from organ impairment, sarcoidosis may affect quality of life which can be quantified by questionnaires. The Leicester Cough Questionnaire (LCQ) has been developed to assess cough-related quality of life. We analysed data from a prospectively collected cohort of sarcoidosis patients for validation of the German LCQ version. Our analyses demonstrated that LCQ values add additional information beyond routinely monitored parameters (e.g. lung function). Only FeV1 and BMI slightly influence LCQ scores, where all other parameters tested did not correlate with LCQ scores. In summary, LCQ is a valuable tool providing information on the patient’ quality of life beyond routine follow-up parameters. FeV1 and BMI may represent treatable traits to reduce cough-related disease burden.



      ACE (angiotensin-converting enzyme), BMI (body mass index), DLCO (Diffusion Capacity of the Lungs for Carbon Monoxide), FeV1 (forced expiratory volume in 1 s), FVC (forced vital capacity), LCQ (Leicester Cough Questionnaire), QoL (quality of life), sIL2R (soluble interleukin-2 receptor), TLC (total lung capacity), VAS (Visual analogue scale (for cough))
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