The emerging role of oxidative stress in complications of COVID-19 and potential therapeutic approach to diminish oxidative stress

Published:September 05, 2021DOI:https://doi.org/10.1016/j.rmed.2021.106605
      The novel coronavirus disease 2019 (COVID-19) has become a pandemic that has threatened healthcare systems worldwide. As of July 19, 2021, this emerging infection had caused 188,655,968 infections and 4,067,517 deaths [
      WHO, Coronavirus disease (COVID-19) pandemic.
      ]. Many unknown factors related to the severity of COVID-19, and which could reduce the death rate from COVID-19, remain to be clarified. Previous studies have stated that oxidative stress is associated with various infectious diseases [
      • Ivanov A.V.
      • Bartosch B.
      • Isaguliants M.G.
      Oxidative stress in infection and consequent disease.
      ,
      • Pizzino G.
      • Irrera N.
      • Cucinotta M.
      • Pallio G.
      • Mannino F.
      • Arcoraci V.
      • Squadrito F.
      • Altavilla D.
      • Bitto A.
      Oxidative stress: harms and benefits for human health.
      ]. Therefore, this study aimed to explore the role of oxidative stress in complications of COVID-19 and investigate possible therapeutic strategies to reduce oxidative stress.

      Keywords

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