The novel coronavirus disease 2019 (COVID-19) has become a pandemic that has threatened
healthcare systems worldwide. As of July 19, 2021, this emerging infection had caused
188,655,968 infections and 4,067,517 deaths [
[1]
]. Many unknown factors related to the severity of COVID-19, and which could reduce
the death rate from COVID-19, remain to be clarified. Previous studies have stated
that oxidative stress is associated with various infectious diseases [
WHO, Coronavirus disease (COVID-19) pandemic.
https://www.who.int/emergencies/diseases/novel-coronavirus-2019
Date accessed: July 19, 2021
[2]
,
[3]
]. Therefore, this study aimed to explore the role of oxidative stress in complications
of COVID-19 and investigate possible therapeutic strategies to reduce oxidative stress.Keywords
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References
- WHO, Coronavirus disease (COVID-19) pandemic.([online]. Available from:)https://www.who.int/emergencies/diseases/novel-coronavirus-2019Date accessed: July 19, 2021
- Oxidative stress in infection and consequent disease.Oxid Med Cell Longev. 2017; 2017: 3496043
- Oxidative stress: harms and benefits for human health.Oxid Med Cell Longev. 2017; 2017: 8416763
- Oxidative stress associated with SARS-Cov-2 (COVID-19) increases the severity of the lung disease-a systematic review.J Infect Dis Epidemiol. 2020; 6
- SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression.Med. Hypotheses. 2020; 143: 110102
- COVID-19 and oxidative stress.Biochemistry (Mosc.). 2020; 85: 1543-1553
- Tissue damage from neutrophil-induced oxidative stress in COVID-19.Nat. Rev. Immunol. 2020; 20: 515-516
- What can cellular redox, iron, and reactive oxygen species suggest about the mechanisms and potential therapy of COVID-19?.Front Cell Infect Microbiol. 2020; 10: 569709
- Crosstalk of reactive oxygen species and NF-kappaB signaling.Cell Res. 2011; 21: 103-115
- NF-kappaB in oxidative stress.Curr Opin Toxicol. 2018; 7: 81-86
- Induction of ROS generation and NF-kappaB activation in MARC-145 cells by a novel porcine reproductive and respiratory syndrome virus in Southwest of China isolate.BMC Vet. Res. 2015; 11: 232
- Iron chelators can protect against oxidative stress through ferryl heme reduction.Free Radic. Biol. Med. 2008; 44: 264-273
- Iron homeostasis and oxidative stress: an intimate relationship.Biochim. Biophys. Acta Mol. Cell Res. 2019; 1866: 118535
- The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia.Ann. N. Y. Acad. Sci. 2010; 1202: 10-16
- Role of iron in oxidative stress in skeletal muscle atrophied by immobilization.Pflügers Archiv. 1992; 421: 295-297
- Iron overload is associated with oxidative stress and nutritional immunity during viral infection in fish.Front. Immunol. 2018; 9: 1296
- Oxidative stress and antioxidant defense.World Allergy Organ J. 2012; 5: 9-19
- Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants.Oxid Med Cell Longev. 2013; 2013956792
- Role of nrf2 in oxidative stress and toxicity.Annu. Rev. Pharmacol. Toxicol. 2013; 53: 401-426
- Nrf2, the master regulator of anti-oxidative responses.Int. J. Mol. Sci. 2017; 18
- Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis.Sci. Rep. 2017; 7: 44769
- Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.Pharmacol. Ther. 2016; 157: 84-104
- Nrf2-Keap1 signaling in oxidative and reductive stress.Biochim. Biophys. Acta Mol. Cell Res. 2018; 1865: 721-733
Article Info
Publication History
Published online: September 05, 2021
Accepted:
September 3,
2021
Received:
July 29,
2021
Identification
Copyright
© 2021 Elsevier Ltd. All rights reserved.
