Highlights
- •Obese patients positive for anti-ARS antibodies have high relapse rates of ILD.
- •Chest fat quantification of SAT and VAT is associated with activity of ILD.
- •Thoracic SAT index is a risk factor for ILD.
Abstract
Background
Obesity is a major risk factor for developing various respiratory diseases. Patients
with anti-aminoacyl tRNA synthetase (ARS) antibodies often have interstitial lung disease (ILD).
The present study was conducted to evaluate the association between obesity and outcomes
of anti-ARS antibody-related ILD (ARS-ILD).
Methods
We retrospectively investigated 58 patients with ARS-ILD and compared the clinical
characteristics, treatment, and prognoses between obese (body mass index [BMI] ≥25 kg/m2) and nonobese (BMI <25 kg/m2) patients. Chest fat was quantified via computed tomography (CT). Thoracic subcutaneous
adipose tissue (SAT) and visceral adipose tissue (VAT) were measured at diagnosis
and first relapse of ILD.
Results
Sixteen patients were obese. Obese patients had lower percentages of predicted diffusing
capacity of the lungs for carbon monoxide and higher high-resolution CT scores and
SAT and VAT indexes than did nonobese patients. The ILD relapse rate was higher in
obese patients (P < 0.01), especially among those with high SAT indexes (P < 0.01). The SAT and VAT indexes increased significantly from diagnosis until first
relapse. Among clinical parameters at first relapse, SAT and VAT indexes were correlated
with serum Krebs von den Lungen‐6 levels (r = 0.720, P = 0.008) and total ground-glass
attenuation scores (r = 0.620, P = 0.024), respectively.
Conclusions
Obesity and high SAT indexes are risk factors for ILD relapse in patients positive
for anti-ARS antibodies. Evaluating and quantifying patients’ chest fat on CT is important
for predicting ILD relapse.
Keywords
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Article info
Publication history
Published online: January 12, 2022
Accepted:
January 9,
2022
Received in revised form:
December 14,
2021
Received:
October 7,
2021
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
