Highlights
- •We show influenza and pneumococcal immunization rates in Greek COPD patients <65.
- •Only 40.2% were vaccinated for influenza and 32.5% for pneumococcus.
- •We report the parameters that positively associate with increased vaccination likelihood.
- •In Greek COPD patients <65 increased health promotion for vaccination is needed.
Abstract
Influenza and pneumococcal pneumonia are major causes of increased morbidity and mortality
among elderly and COPD patients. Vaccines against influenza and pneumococcus are recommended
for COPD patients according to GOLD 2020 guidelines to prevent serious illnesses.
Despite their high morbidity and mortality burden, the vaccination coverage rates
remain far below the WHO's recommended targets. In Greece, there are insufficient
data on influenza and pneumococcal immunization rates among younger COPD patients.
This study investigated whether COPD patients under the age of 65 are adequately vaccinated
against influenza and pneumococcus and the factors that influence vaccination rates.
1100 individuals at 22 Primary Health Centers in Central Greece participated in a
two-year spirometry monitoring program. Face-to-face interviews were used to collect
information regarding demographics, smoking status, comorbidities, respiratory illnesses
in the previous two years, and influenza and pneumococcal vaccination coverage from
all COPD patients. 117 patients aged 40–65 years old were diagnosed with COPD and
80.3% were males. Only 40.2% of them had received influenza and 32.5% pneumococcus
vaccinations. Age, advanced stage of COPD, years on COPD diagnosis, respiratory infection
within the previous two years, comorbidity, and smoking cessation are all positively
connected with influenza and pneumococcus vaccine coverage in younger COPD patients.
Gender, education level, and marital status did not affect influenza and pneumococcus
vaccination rates. These vaccination rates among younger COPD patients demonstrate
the need for increased awareness and knowledge about the advantages of immunizations
in lowering morbidity and mortality.
Keywords
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References
- Determinants of influenza vaccination among high-risk Black and White adults.Vaccine. 2017; 35: 7154-7159https://doi.org/10.1016/j.vaccine.2017.10.083
- Factors associated with influenza and pneumococcal vaccination behavior among high-risk adults.J. Gen. Intern. Med. 1996; 11: 673-677https://doi.org/10.1007/bf02600158
- Factors associated to repeated influenza vaccination in the Portuguese adults with chronic conditions.Vaccine. 2018; 36: 5265-5272https://doi.org/10.1016/j.vaccine.2018.07.041
- Vaccination coverage of the elderly in Greece: a cross-sectional nationwide study.Can. J. Infect Dis. Med. Microbiol. 2020; 2020https://doi.org/10.1155/2020/5459793
- Impact of the Financial Crisis on COPD Burden : Greece as a Case Study.(1-10)
- Underestimation of respiratory symptoms by smokers: a thorn in chronic obstructive pulmonary disease diagnosis.Npj Prim. Care Respir. Med. 2021; 31: 1-8https://doi.org/10.1038/s41533-021-00226-y
- Press release follow UP OF reported cases of infectious diseases.Hell. Stat. Auth. 2017; 2017 (2018)
- Exacerbations of COPD.Eur. Respir. Rev. 2018; 27https://doi.org/10.1183/16000617.0103-2017
- Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease.Thorax. 2005; 60: 925-931https://doi.org/10.1136/thx.2005.040527
- Influenza and pneumonia vaccination rates and factors affecting vaccination among patients with chronic obstructive pulmonary disease.Balkan Med. J. 2017; 34: 206-211https://doi.org/10.4274/balkanmedj.2016.1028
- Role of infection in exacerbations of chronic obstructive pulmonary disease.Curr. Opin. Pulm. Med. 2015; 21: 278-283https://doi.org/10.1097/MCP.0000000000000154
- Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review.Respirology. 2010; 15: 536-542https://doi.org/10.1111/j.1440-1843.2010.01722.x
- Seasonal influenza vaccination in patients with COPD: a systematic literature review.BMC Pulm. Med. 2017; 17: 1-15https://doi.org/10.1186/s12890-017-0420-8
- 2020 report, glob. Initiat. Chronic obstr. Lung dis.(23-58)
- How close are countries of the WHO European Region to achieving the goal of vaccinating 75% of key risk groups against influenza? Results from national surveys on seasonal influenza vaccination programmes.Vaccine. 2018; 36 (2008/2009 to 2014/2015): 442-452https://doi.org/10.1016/j.vaccine.2017.12.019
- Immunization and Infectious Diseases | Healthy People 2020.HealthyPeople.Gov, 2016
- Factsheet about Seasonal Influenza. vols. 1–7. 2017
- Clinical and economic burden of community-acquired pneumonia among adults in Europe.Thorax. 2012; 67: 71-79https://doi.org/10.1136/thx.2009.129502
- Low vaccination coverage for seasonal influenza and pneumococcal disease among adults at-risk and health care workers in Ireland.in: The key role of GPs in recommending vaccination, Vaccine. 34. 2013: 3657-3662https://doi.org/10.1016/j.vaccine.2016.05.028 (2016)
- Vaccination coverage in patients affected by chronic diseases: a 2014 cross-sectional study among subjects hospitalized at Bari Policlinico General Hospital.Am. J. Infect. Control. 2018; 46: e9-e11https://doi.org/10.1016/j.ajic.2017.10.004
- Vaccination rates among the general adult population and high-risk groups in the United States.PLoS One. 2012; 7https://doi.org/10.1371/journal.pone.0050553
- Pneumococcal vaccination coverages by age, sex and specific underlying risk conditions among middle-aged and older adults in Catalonia, Spain.Euro Surveill. 2017; 24: 1-9https://doi.org/10.2807/1560-7917.ES.2019.24.29.1800446
- Standardization of spirometry 2019 update an official American Thoracic Society and European Respiratory Society technical statement.Am. J. Respir. Crit. Care Med. 2019; 200: E70-E88https://doi.org/10.1164/rccm.201908-1590ST
- Spirometry: step by step.Breathe. 2012; 8: 233-240https://doi.org/10.1183/20734735.0021711
- Classification of COPD patients and compliance to recommended treatment in Greece according to GOLD 2017 report: the RELICO study.BMC Pulm. Med. 2021; 21: 1-9https://doi.org/10.1186/s12890-021-01576-6
- Vaccination coverage of recommended vaccines and determinants of vaccination in at-risk groups.Hum. Vaccines Immunother. 2020; 16: 2136-2143https://doi.org/10.1080/21645515.2020.1763739
- Identification of barriers to influenza vaccination in patients with chronic obstructive pulmonary disease: analysis of the 2012 behavioral risk factors surveillance survey, chronic obstr.Pulm. Dis. J. COPD Found. 2016; 3: 620-627https://doi.org/10.15326/jcopdf.3.3.2015.0156
- Seasonal Influenza Vaccination in Europe.2017
- Adult Pneumonia Vaccination Understanding in Europe : 65 Years and over.2017: 1-12
- Influenza vaccination rate and its association with chronic diseases in China: results of a national cross-sectional study.Vaccine. 2020; 38: 2503-2511https://doi.org/10.1016/j.vaccine.2020.01.093
- Factors affecting influenza vaccination in adults aged 50-64 years with high-risk chronic diseases in South Korea.Hum. Vaccines Immunother. 2019; 15: 959-966https://doi.org/10.1080/21645515.2018.1556075
- Grading the severity of airways obstruction: new wine in new bottles.Eur. Respir. J. 2014; 43: 505-512https://doi.org/10.1183/09031936.00086313
- Chronic obstructive pulmonary disease and risk of infection.Pneumonol. Alergol. Pol. 2009; 77: 284-288
- Infection as a comorbidity of COPD.Eur. Respir. J. 2010; 35: 1209-1215https://doi.org/10.1183/09031936.00081409
- Vaccination of special populations: protecting the vulnerable.Vaccine. 2016; 34: 6681-6690https://doi.org/10.1016/j.vaccine.2016.11.015
- The free vaccination policy of influenza in Beijing, China: the vaccine coverage and its associated factors.Vaccine. 2016; 34: 2135-2140https://doi.org/10.1016/j.vaccine.2016.02.032
- Pneumococcal vaccination and chronic respiratory diseases.Int. J. COPD. 2017; 12: 3457-3468https://doi.org/10.2147/COPD.S140378
- Predictors of vaccination behavior among persons ages 65 years and older.Am. J. Publ. Health. 1990; 80: 1127-1129https://doi.org/10.2105/AJPH.80.9.1127
- Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada.Int. J. COPD. 2019; 14: 2003-2013https://doi.org/10.2147/COPD.S210897
- Impaired systemic cell-mediated immunity and increased susceptibility to acute respiratory tract infections in patients with COPD.Respir. Med. 2005; 99: 485-492https://doi.org/10.1016/j.rmed.2004.09.013
- Influenza and Morbidity and Mortality Risk in Patients in Mexico with Systemic Arterial Hypertension Alone or with Comorbidities: A Retrospective, Observational, Cross-Sectional Study from 2014 to 2020. 11. BMJ Open, 2021: 1-9https://doi.org/10.1136/bmjopen-2021-057225
- Influenza vaccines for preventing cardiovascular disease.Sao Paulo Med. J. 2015; 133: 384https://doi.org/10.1590/1516-3180.20151334T2
- Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review.Lancet Infect. Dis. 2009; 9: 601-610https://doi.org/10.1016/S1473-3099(09)70233-6
- Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis.JAMA, J. Am. Med. Assoc. 2013; 310: 1711-1720https://doi.org/10.1001/jama.2013.279206
- The impact of influenza vaccination in patients with cardiovascular disease: an overview of systematic reviews.Trends Cardiovasc. Med. 2021; 31: 315-320https://doi.org/10.1016/j.tcm.2020.06.003
- Identifying behavioral phenotypes in chronic illness: self-management of COPD and comorbid hypertension.Patient Educ. Counsel. 2021; 104: 627-633https://doi.org/10.1016/j.pec.2020.08.025
- PneuVUE: a new view into pneumonia among older adults.
- Socioeconomic status and other related factors of seasonal influenza vaccination in the South Korean adult population based on a nationwide cross-sectional study.PLoS One. 2015; 10: 1-12https://doi.org/10.1371/journal.pone.0117305
- Health coaching and chronic obstructive pulmonary disease rehospitalization: a randomized study.Am. J. Respir. Crit. Care Med. 2016; 194: 672-680https://doi.org/10.1164/rccm.201512-2503OC
Article info
Publication history
Published online: September 14, 2022
Accepted:
September 9,
2022
Received in revised form:
August 31,
2022
Received:
June 14,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.