Highlights
- •Lower respiratory infections remain a major public health problem threatening human health.
- •The burden of lower respiratory infections in 2019 varies greatly due to geographical location.
- •Our results can help public health policymakers develop and implement targeted prevention and management programs.
Abstract
Background
This study provides a comprehensive, comparative and updated estimates of temporal
patterns of lower respiratory infections (LRIs) globally over the past three decades.
Methods
The data on morbidity and mortality of patients with LRIs at the global, regional
and national levels were retrieved from the Global Burden of Disease (GBD) 2019 study.
Results
Globally, the incident cases of LRIs increased from 414,342,866 [95% uncertainty interval
(UI):383,529,625 to 449, 086,938]in 1990 to 488,902,504(95% UI: 457,572,987 to 522,635,542)in
2019 with the age standardized incidence rate (ASIR) decreased from 8,276/100,000
persons (95% UI: 7,727 to 8,892) to 6,295/100,000 persons (95% UI: 5,887 to 6,737)
between 1990 and 2019. Number of LRIs deaths were 2,493,200 (95% UI: 2,268,184 to
2,736,184) in 2019, a decrease of 24.9% (95% UI: −34.4 to −15.4) in the past 30 years.
Meanwhile, the age-standardized death rate (ASDR) declined also from 67/100,000 persons
(95% UI: 61 to 73) in 1990 to 34/100,000 persons (95% UI: 31 to 38) in 2019. Moreover,
the numbers and age-standardized rates per 100,000 persons of morbidity and mortality
varied widely by age, sex, Socio-Demographic Index (SDI) quintiles, and geographical
locations in 2019.
Conclusion
LRIs remain a major public health concern . Some differences in age, sex, SDI quintiles,
and geographical locations contribute to LRIs-related global health policy development
and health system resource optimization.
Keywords
Abbreviations:
LRIs (lower respiratory infections), GBD (Global Burden of Disease), UI (uncertainty interval), ASIR (age standardized incidence rate), ASDR (age-standardized death rate), SDI (Socio-Demographic Index), ASR (age-standardized rate), EAPC (estimated annual percentage change), CI (confidence interval)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 13, 2022
Accepted:
November 8,
2022
Received in revised form:
November 5,
2022
Received:
September 14,
2022
Identification
Copyright
Published by Elsevier Ltd.
