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Adipocytokines in obstructive sleep apnea: A systematic review and meta-analysis

Published:January 19, 2023DOI:https://doi.org/10.1016/j.rmed.2023.107122

      Highlights

      • The levels of inflammatory markers were found to be higher in OSA patients compared with control individuals.
      • The most considerable inflammatory cytokines elevating in OSA patients are IL-8, IL-17 and IL-1β.
      • Some adipose active substances like vaspin, visfatin, and chemerin are linked to a greater serum levels in adult patients with OSA.
      • The anti-inflammatory cytokine IL-4 can exert proinflammatory effect in OSA patients.

      Abstract

      Background and aim

      Adipocytokines play an important role in obstructive sleep apnea (OSA) by mediating inflammatory responses. Previous studies have reported that OSA is related to a change in the serum levels of adipocytokines; however, the results are still controversial. This meta-analysis aimed to assess the relationship between OSA and circulating level of adipocytokines in adults and children.

      Methods

      A comprehensive search was conducted in databases of Medline/PubMed and Scopus for pertinent articles published since their inception to July 2022. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were used to assess the strength of the relationship between the concentrations of adipocytokines with OSA.

      Results

      In the overall analysis, contrary to IL-10, which showed a significant reduction, IL-1β, IL-4, IL-8, IL-17, and IFN- gamma showed higher levels in OSA patients in comparison with control groups (p <0.05). For adults, IL-1β, IL-8, IL-17, IL-18, vaspin, visfatin, and chemerin were linked to a greater serum levels in patients with OSA, while, IL-5 and IL-10 were detected significantly lower in adults with OSA in comparison with healthy adults (p <0.05). In children with OSA, the serum levels of IL-4, IL-8, IL-12, IL-17, IL-23, and IFN-gamma were significantly higher than healthy children (p <0.05).

      Conclusion

      The levels of inflammatory markers were found to be higher in OSA patients compared with control individuals, suggesting that adipocytokines may contribute to the pathology of OSA.

      Keywords

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