Focus on Sarcoidosis
Current perspectives on the immunopathogenesis of sarcoidosisSarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis.
Correspondence for "clinical epidemiology of familial sarcoidosis: A systematic literature review"We have read the very interesting article titled “Clinical epidemiology of familial sarcoidosis: a systematic literature review” by Drs. Terwiel and van Moorsel published recently in Respiratory medicine . The work was based on the very stringent selection of 27 articles out of a total of 459 published on sarcoidosis in order to obtain a high level of statistical quality in the evaluation of the prevalence of familial forms. This review took into account all articles published until March 2018, date of submission to Respiratory Medicine.
Correspondence for “Clinical epidemiology of familial sarcoidosis: A systematic literature review”It is with great interest that we read the article titled “Clinical epidemiology of familial sarcoidosis: A systematic literature review” by Drs. Terwiel and van Moorsel published recently in Respiratory Medicine . Their systematic review on familial sarcoidosis highlights the great heterogeneity in familial disease prevalence and in familial relative risks among published studies. They also emphasize the high heritability (>60%) of sarcoidosis.
Clinical epidemiology of familial sarcoidosis: A systematic literature reviewAlthough the presence of familial sarcoidosis has been confirmed, clinical and epidemiological data on its characteristics are scattered and sometimes paradoxical. The objective of this review is to assess what is known on the clinical epidemiology of familial sarcoidosis, by combining data from early case reports with recent population based data; aiming to support in clinical decision making and providing information to patients.
Response to Letter to Editor regarding "Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?"We thank Drs. Valentin, Hyde, Gomez and Patel for commenting on our recently published article “Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?” . Indeed, one of our objectives in reporting our observations was to provoke further interest in the scientific community regarding such patients and conduct of clinical studies in such cohorts.
Letter to the editorIt was with great interest we read the article by Dr. Collins and colleagues published in the August 2018 edition of Respiratory Medicine, titled “Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?” The authors describe the characteristics of a disease entity they coined “combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF)” . We appreciate the authors’ efforts to shed light on this clinical entity, which to date has sparked debate in terms of proper classification of patients who share radiographic and histopathologic features of sarcoidosis and idiopathic pulmonary fibrosis (IPF).
Sarcoidosis in WTC-Exposed workersWithout adequate attention to the incidence and prevalence of surveillance with diagnostic technology, and without suitable consideration of the technologic effects on what becomes detected or left unidentified, the rates of reported diseases simply represent the rates of diagnostic detection and cannot be accepted as scientific enumeration of the true incidence and prevalence of those diseases. .